Casein kinase

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Casein kinase is a kinase enzyme.



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Casein pronounced "kay-seen" in British English, is a family of related phosphoproteins. These proteins are commonly found in mammalian milk, comprising c. 80% of the proteins in cow's milk and between 20% and 45% of the proteins in human milk.The j Casein has a wide variety of uses, from being a major component of cheese, to use as a food additive. The most common form of casein is sodium caseinate.

MuSK protein protein-coding gene in the species Homo sapiens

MuSK is a receptor tyrosine kinase required for the formation and maintenance of the neuromuscular junction. It is activated by a nerve-derived proteoglycan called agrin.

The Casein kinase 1 family of protein kinases are serine/threonine-selective enzymes that function as regulators of signal transduction pathways in most eukaryotic cell types. CK1 isoforms are involved in Wnt signaling, circadian rhythms, nucleo-cytoplasmic shuttling of transcription factors, DNA repair, and DNA transcription.

Casein kinase 2 (CK2/CSNK2) is a serine/threonine-selective protein kinase that has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm, and other cellular processes. De-regulation of CK2 has been linked to tumorigenesis as a potential protection mechanism for mutated cells. Proper CK2 function is necessary for survival of cells as no knockout models have been successfully generated.

Serine/threonine-specific protein kinase

A serine/threonine protein kinase is a kinase enzyme that phosphorylates the OH group of serine or threonine. At least 125 of the 500+ human protein kinases are serine/threonine kinases (STK).

Casein kinases may refer to:

CSNK1D protein-coding gene in the species Homo sapiens

The CSNK1D gene encodes the casein kinase I isoform delta enzyme in humans.

Casein kinase I isoform epsilon is an enzyme that in humans is encoded by the CSNK1E gene.

Casein kinase 2, alpha 1 protein-coding gene in the species Homo sapiens

Casein kinase II subunit alpha is an enzyme that in humans is encoded by the CSNK2A1 gene.

CSNK2A2 protein-coding gene in the species Homo sapiens

Casein kinase II subunit alpha' is an enzyme that in humans is encoded by the CSNK2A2 gene.

ATF1 protein-coding gene in the species Homo sapiens

Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.

CSNK2B protein-coding gene in the species Homo sapiens

Casein kinase II subunit beta is a protein that in humans is encoded by the CSNK2B gene.

In enzymology, a low-density-lipoprotein receptor kinase is an enzyme that catalyzes the chemical reaction

MAP3K1 protein-coding gene in the species Homo sapiens

Mitogen-activated protein kinase kinase kinase 1 is an enzyme that in humans is encoded by the MAP3K1 gene.

CSN1S1 protein-coding gene in the species Homo sapiens

Alpha-S1-casein is a protein that in humans is encoded by the CSN1S1 gene.

Casein kinase 1, alpha 1 protein-coding gene in the species Homo sapiens

Casein kinase I isoform alpha is an enzyme that in humans is encoded by the CSNK1A1 gene.

CK2 can refer to the following:

PF-4800567 chemical compound

PF-4800567 is a drug developed by Pfizer which acts as a selective inhibitor of the enzyme Casein kinase 1 epsilon (CK1-ε), and has mainly been used in the study of the casein kinase 1 enzymes in the regulation of circadian rhythm, as well as showing potential neuroprotective effects. While this research has shown that circadian rhythm is modulated primarily by the alternate isoform CK1-δ rather than CK1-ε, both PF-4800567 and the related non-selective CK1-δ/ε inhibitor PF-670462 were found in animal studies to enhance responses to certain drugs of abuse such as methamphetamine and fentanyl, which suggests a role for CK1-ε in negative regulation of sensitivity to stimulant and opioid drugs.

Casein kinase 1 isoform epsilon protein-coding gene in the species Homo sapiens

Casein kinase I isoform epsilon or CK1ε, is an enzyme that in humans is encoded by the CSNK1E gene. CK1ε is a serine/threonine protein kinase and is very highly conserved; therefore, this kinase is very similar to other members of the casein kinase 1 family. This gene is a major component of the mammalian oscillator which controls cellular circadian rhythms.

Silmitasertib

Silmitasertib (INN), codenamed CX-4945, is a small-molecule inhibitor of protein kinase CK2, a constitutively active serine/threonine-specific protein kinase that is overexpressed in several types of tumors.