Choline/ethanolamine kinase family

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Choline_kinase
PDB 1nw1 EBI.jpg
crystal structure of choline kinase
Identifiers
SymbolCholine_kinase
Pfam PF01633
Pfam clan CL0016
InterPro IPR002573

In molecular biology, the choline/ethanolamine kinase family includes choline kinase(EC 2.7.1.32) and ethanolamine kinase (EC 2.7.1.82).

Ethanolamine and choline are major membrane phospholipids, in the form of glycerophosphoethanolamine and glycerophosphocholine. Ethanolamine is also a component of the glycosylphosphatidylinositol (GPI) anchor, which is necessary for cell-surface protein attachment. [1] The de novo synthesis of these phospholipids begins with the creation of phosphoethanolamine and phosphocholine by ethanolamine and choline kinases in the first step of the CDP-ethanolamine pathway. [2] [3] There are two putative choline/ethanolamine kinases (C/EKs) in the Trypanosoma brucei genome.

Ethanolamine kinase has no choline kinase activity [1] and its activity is inhibited by ADP. [3] Inositol supplementation represses ethanolamine kinase, decreasing the incorporation of ethanolamine into the CDP-ethanolamine pathway and into phosphatidylethanolamine and phosphatidylcholine. [4]

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References

  1. 1 2 Gibellini F, Hunter WN, Smith TK (October 2008). "Biochemical characterization of the initial steps of the Kennedy pathway in Trypanosoma brucei: the ethanolamine and choline kinases". Biochem. J. 415 (1): 135–44. doi:10.1042/BJ20080435. PMC   2552378 . PMID   18489261.
  2. ↑ Tian Y, Jackson P, Gunter C, Wang J, Rock CO, Jackowski S (September 2006). "Placental thrombosis and spontaneous fetal death in mice deficient in ethanolamine kinase 2". J. Biol. Chem. 281 (38): 28438–49. doi: 10.1074/jbc.M605861200 . PMID   16861741.
  3. 1 2 Kim KH, Voelker DR, Flocco MT, Carman GM (March 1998). "Expression, purification, and characterization of choline kinase, product of the CKI gene from Saccharomyces cerevisiae". J. Biol. Chem. 273 (12): 6844–52. doi: 10.1074/jbc.273.12.6844 . PMID   9506987.
  4. ↑ Kersting MC, Choi HS, Carman GM (August 2004). "Regulation of the yeast EKI1-encoded ethanolamine kinase by inositol and choline". J. Biol. Chem. 279 (34): 35353–9. doi: 10.1074/jbc.M405704200 . PMID   15201274.
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