Coagulation, also known as clotting, is the process by which blood changes from a liquid to a gel, forming a blood clot. It results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. The process of coagulation involves activation, adhesion and aggregation of platelets, as well as deposition and maturation of fibrin.
Fibrinogen is a glycoprotein complex, produced in the liver, that circulates in the blood of all vertebrates. During tissue and vascular injury, it is converted enzymatically by thrombin to fibrin and then to a fibrin-based blood clot. Fibrin clots function primarily to occlude blood vessels to stop bleeding. Fibrin also binds and reduces the activity of thrombin. This activity, sometimes referred to as antithrombin I, limits clotting. Fibrin also mediates blood platelet and endothelial cell spreading, tissue fibroblast proliferation, capillary tube formation, and angiogenesis and thereby promotes revascularization and wound healing.
In biology, hemostasis or haemostasis is a process to prevent and stop bleeding, meaning to keep blood within a damaged blood vessel. It is the first stage of wound healing. Hemostasis involves three major steps:
Compression stockings are a specialized hosiery designed to help prevent the occurrence of, and guard against further progression of, venous disorders such as edema, phlebitis and thrombosis. Compression stockings are elastic compression garments worn around the leg, compressing the limb. This reduces the diameter of distended veins and increases venous blood flow velocity and valve effectiveness. Compression therapy helps decrease venous pressure, prevents venous stasis and impairments of venous walls, and relieves heavy and aching legs.
Lepirudin is an anticoagulant that functions as a direct thrombin inhibitor.
The Journal of Consulting and Clinical Psychology is a monthly peer-reviewed academic journal published by the American Psychological Association. It covers research on treatment and prevention in all areas of clinical psychology. The editor-in-chief is Pim Cuijpers.
A rectus sheath hematoma is an accumulation of blood in the sheath of the rectus abdominis muscle. It causes abdominal pain with or without a mass.
The dysfibrinogenemias consist of three types of fibrinogen disorders in which a critical blood clotting factor, fibrinogen, circulates at normal levels but is dysfunctional. Congenital dysfibrinogenemia is an inherited disorder in which one of the parental genes produces an abnormal fibrinogen. This fibrinogen interferes with normal blood clotting and/or lysis of blood clots. The condition therefore may cause pathological bleeding and/or thrombosis. Acquired dysfibrinogenemia is a non-hereditary disorder in which fibrinogen is dysfunctional due to the presence of liver disease, autoimmune disease, a plasma cell dyscrasias, or certain cancers. It is associated primarily with pathological bleeding. Hereditary fibrinogen Aα-Chain amyloidosis is a sub-category of congenital dysfibrinogenemia in which the dysfunctional fibrinogen does not cause bleeding or thrombosis but rather gradually accumulates in, and disrupts the function of, the kidney.
Picotamide is a platelet aggregation inhibitor. It works as a thromboxane synthase inhibitor and a thromboxane receptor inhibitor, the latter by modifying cellular responses to activation of the thromboxane receptor. Picotamide is licensed in Italy for the treatment of clinical arterial thrombosis and peripheral artery disease.
Sticky platelet syndrome (SPS) is a heritable disorder of platelet function in which platelet hyperaggregation leads to hypercoagulability. It was first described by Mammen in 1983. It is inherited in an autosomal dominant pattern. It has not been associated with a specific gene, and it is not recognized as an entity in OMIM.
The Journal of Clinical Psychiatry is a peer-reviewed medical journal that covers clinical psychiatry, especially depression, bipolar disorder, schizophrenia, anxiety, addiction, and attention-deficit/hyperactivity disorder, as well as several other mental disorders. It is the official journal of the American Society for Clinical Psychopharmacology and was established in 1940 as Diseases of the Nervous System, before obtaining its current name in 1979.
Atherosclerosis is a monthly peer-reviewed scientific journal established in 1970 and published by Elsevier. It is the official journal of the European Atherosclerosis Society and is affiliated with the International Atherosclerosis Society.
American Behavioral Scientist is a peer-reviewed academic journal that publishes papers in the fields of social and behavioral sciences. The managing editor is Laura Lawrie. It was established in 1957 by Alfred de Grazia and is currently published by SAGE Publications, who acquired the journal from de Grazia.
The International Society on Thrombosis and Haemostasis (ISTH) is a not-for-profit global membership organization of specialists in the field of blood coagulation and its disorders, such as thrombosis and hemophilia. It was founded in 1954 as the International Committee on Thrombosis and Haemostasis (ICTH). The society was reorganized in 1969 as the ISTH. It currently represents about 5,000 members from 98 different countries. The society initiates and promotes education and outreach initiatives, research activities, scientific meetings, peer-reviewed publications, expert committees and the development of standards allowing a common language and approach to basic and clinical science all over the world. It also publishes the medical journal Journal of Thrombosis and Haemostasis and its open access counterpart, Research and Practice in Thrombosis and Haemostasis.
Assessment (ASMNT) is a peer-reviewed academic journal that covers research in the field of psychology, especially applied clinical assessment. The editor is Douglas B. Samuel. It was established in 1994 and is currently published by SAGE Publications. This journal is a member of the Committee on Publication Ethics (COPE).
Expert Review of Hematology is a MEDLINE-indexed, peer-reviewed, international medical journal publishing review articles and original papers on all aspects of hematology. It is part of the Expert Review series, published by Informa.
Thrombosis Research is an international peer-reviewed medical journal published by Elsevier with a goal of rapid dissemination of new information on thrombosis, hemostasis, and vascular biology to advance science and clinical care. The journal publishes peer-reviewed original research, along with reviews, editorials, and opinions and critics. Both basic and clinical studies are published. Publication of research which will lead to novel approaches in diagnosis, therapy, prognosis and prevention of thrombotic and hemorrhagic diseases is given high priority.
Thrombosis and Haemostasis is a peer-review scientific journal of medicine. It is published by Thieme Medical Publishers. It is the official journal of several groups and societies: European Society of Cardiology, Sociedad Española de Trombosis y Hemostasia, Australian Vascular Biology Society, and Gesellschaft für Thrombose- und Hämostaseforschung e.V. A related publication is TH Open. The journal was established in 1957 and is published monthly. The current editors-in-chief are Christian Weber and Gregory Y. H. Lip.
Seminars in Thrombosis and Hemostasis is a peer-reviewed medical review journal covering hematology, with a specific focus on disorders related to thrombosis and hemostasis. It was established in 1974 and is published eight times per year by Thieme Medical Publishers. The editor-in-chief is Emmanuel J. Favaloro. According to the Journal Citation Reports, the journal has a 2018 impact factor of 3.401.
Marie Claire McLintock was a New Zealand haematologist and obstetric physician. She was an expert in medical conditions and disorders related to bleeding and blood clotting, and medical problems associated with pregnancy.
