Compound 48/80

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Compound 48/80
Compound 48-80.svg
Names
IUPAC name
Poly({2-methoxy-5-[2-(methylamino)ethyl]-1,3-phenylene}methylene)
Identifiers
RTECS number
  • Gk2402500
UN number 2811
Properties
(C11H15NO)n
Molar mass Variable
50 mg/mL [1]
Hazards
GHS labelling:
H301, H311, H331
P233, P261, P280, P301, P302, P304, P310, P312, P330, P340, P352, P403
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Compound 48/80 is a polymer produced by the condensation of N-methyl-p-methoxyphenethylamine with formaldehyde. [1] It promotes histamine release, [2] and in biochemical research, compound 48/80 is used to promote mast cell degranulation. [3]

References

  1. 1 2 "Compound48/80". Sigma-Aldrich.
  2. ↑ A. M. Rothschild (1970). "Mechanisms of histamine release by compound 48/80". Br J Pharmacol. 38 (1): 253–262. doi:10.1111/j.1476-5381.1970.tb10354.x. PMC   1702640 . PMID   4189829.
  3. ↑ Schemann, Michael; Kugler, Eva Maria; Buhner, Sabine; Eastwood, Christopher; Donovan, Jemma; Jiang, Wen; Grundy, David (2012). "The Mast Cell Degranulator Compound 48/80 Directly Activates Neurons". PLOS ONE. 7 (12) e52104. Bibcode:2012PLoSO...752104S. doi: 10.1371/journal.pone.0052104 . PMC   3525567 . PMID   23272218.


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