Doravirine/lamivudine/tenofovir

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Doravirine/lamivudine/tenofovir
Combination of
Doravirine Non-nucleoside reverse transcriptase inhibitor
Lamivudine Nucleoside reverse transcriptase inhibitor
Tenofovir disoproxil Nucleotide reverse transcriptase inhibitor
Clinical data
Trade names Delstrigo
Other namesMK-1439A
AHFS/Drugs.com Monograph
MedlinePlus a618049
License data
Routes of
administration
By mouth
ATC code
Legal status
Legal status
Identifiers
CAS Number
KEGG

Doravirine/lamivudine/tenofovir, sold under the brand name Delstrigo, is a fixed-dose combination antiretroviral medication for the treatment of HIV/AIDS. [4] [6] It contains doravirine, lamivudine, and tenofovir disoproxil. [7] [6] It is taken by mouth. [4]

In the United States, it was approved by the Food and Drug Administration (FDA) for the treatment of HIV-1 infection in August 2018. [7] [8] [9]

References

  1. "PRODUCT MONOGRAPH INCLUDING PATIENT MEDICATION INFORMATION : DELSTRIGO" (PDF). Pdf.hres.ca. Retrieved 5 June 2022.
  2. "Drug and medical device highlights 2018: Helping you maintain and improve your health". Health Canada . 14 October 2020. Retrieved 17 April 2024.
  3. "Delstrigo 100 mg /300 mg /245 mg film-coated tablets - Summary of Product Characteristics (SmPC)". Medicines.org.uk. 8 July 2020. Retrieved 1 October 2020.
  4. 1 2 3 "Delstrigo- doravirine, lamivudine, and tenofovir disoproxil fumarate tablet, film coated". DailyMed. 10 October 2019. Retrieved 31 July 2020.
  5. "Delstrigo EPAR". European Medicines Agency (EMA). 21 September 2018. Retrieved 1 October 2020.
  6. 1 2 Canadian Agency for Drugs and Technologies in Health (June 2019). "Common Drug Review New Combination Product: Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate Fixed-Dose Combination (Delstrigo)". CADTH Common Drug Reviews. Ottawa (ON). PMID   31393687.
  7. 1 2 "FDA Approves Merck's Delstrigo (doravirine / lamivudine / tenofovir disoproxil fumarate), a Once-Daily Fixed-Dose Combination Tablet as a Complete Regimen and Pifeltro (doravirine), an NNRTI, Both for the Treatment of HIV-1 in Appropriate Patients" (Press release). Merck & Co. 30 August 2018.
  8. "Delstrigo approval letter" (PDF). Food and Drug Administration (FDA). 30 August 2018. Archived from the original (PDF) on 21 March 2019. Retrieved 10 September 2019.
  9. "Drug Approval Package: Pifeltro (doravirine)". U.S. Food and Drug Administration (FDA). 9 October 2018. Archived from the original on 1 October 2020. Retrieved 22 September 2020.