Enah/Vasp-like

EVL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1QC6
Identifiers
Aliases	EVL , RNB6, Enah/Vasp-like
External IDs	OMIM: 616912 MGI: 1194884 HomoloGene: 56752 GeneCards: EVL
Gene location (Human)
Chr.	Chromosome 14 (human)
End	100,144,236 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	108,654,775 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; lymph node; ; nucleus accumbens; ; prefrontal cortex; ; anterior pituitary; ; caudate nucleus; ; spleen; ; Brodmann area 9; ; amygdala; ; putamen;
	Top expressed in
	dorsomedial hypothalamic nucleus; ; ganglionic eminence; ; molar; ; lateral hypothalamus; ; habenula; ; dorsal tegmental nucleus; ; olfactory bulb; ; superior cervical ganglion; ; mammillary body; ; medial dorsal nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	profilin binding ; SH3 domain binding ; protein binding ; actin binding ;
Cellular component	cytoplasm ; cytosol ; cell projection ; membrane ; focal adhesion ; cytoskeleton ; lamellipodium ; phagocytic vesicle ;
Biological process	positive regulation of actin filament polymerization ; negative regulation of ruffle assembly ; actin filament organization ; nervous system development ; axon guidance ; cell surface receptor signaling pathway ; animal organ morphogenesis ; actin polymerization or depolymerization ; protein homotetramerization ; negative regulation of epithelial cell migration ; positive regulation of stress fiber assembly ; actin nucleation ; cellular response to interferon-gamma ;
	Sources:Amigo / QuickGO
Orthologs
	51466
	14026
	ENSG00000196405
	ENSMUSG00000021262
	Q9UI08
	P70429
	NM_016337 ; NM_001330221
	NM_001163394 ; NM_001163395 ; NM_001163396 ; NM_007965
	NP_001317150 ; NP_057421
	NP_001156866 ; NP_001156867 ; NP_001156868 ; NP_031991
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 17, 2022

Ena/VASP-like protein is a member of the Ena/VASP family of proteins that in humans is encoded by the EVL gene.^[5]^[6]^[7]

Related Research Articles

ENA/VASP homology proteins or EVH proteins are a family of closely related proteins involved in cell motility in vertebrate and invertebrate animals. EVH proteins are modular proteins that are involved in actin polymerization, as well as interactions with other proteins. Within the cell, Ena/VASP proteins are found at the leading edge of Lamellipodia and at the tips of filopodia. Ena, the founding member of the family was discovered in a drosophila genetic screen for mutations that act as dominant suppressors of the abl non receptor tyrosine kinase. Invertebrate animals have one Ena homologue, whereas mammals have three, named Mena, VASP, and Evl.

Dynamin-2 is a protein that in humans is encoded by the DNM2 gene.

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Neurabin-2 is a protein that in humans is encoded by the PPP1R9B gene.

Filamin-binding LIM protein 1 is a protein that in humans is encoded by the FBLIM1 gene.

Prostaglandin F2 receptor negative regulator is a protein that in humans is encoded by the PTGFRN gene. PTGFRN has also been designated as CD315.

EH-domain containing 2, also known as EHD2, is a human gene belonging to the EHD protein family.

Myosin-IIIa is a protein that in humans is encoded by the MYO3A gene.

Ras-associated and pleckstrin homology domains-containing protein 1 is a protein that in humans is encoded by the RAPH1 gene.

Semaphorin-6A is a protein that in humans is encoded by the SEMA6A gene.

Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1IP), also known as APBB1-interacting protein 1 or Rap1-GTP-interacting adapter molecule (RIAM) is a protein that in humans is encoded by the APBB1IP gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000196405 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021262 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lambrechts A, Kwiatkowski AV, Lanier LM, Bear JE, Vandekerckhove J, Ampe C, Gertler FB (Dec 2000). "cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains". J Biol Chem. 275 (46): 36143–51. doi: 10.1074/jbc.M006274200 . PMID 10945997.
↑ Klostermann A, Lutz B, Gertler F, Behl C (Jan 2001). "The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain". J Biol Chem. 275 (50): 39647–53. doi: 10.1074/jbc.M006316200 . PMID 10993894.
↑ "Entrez Gene: EVL Enah/Vasp-like".

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146 . PMID 9110174.
Ohta S, Mineta T, Kimoto M, Tabuchi K (1997). "Differential display cloning of a novel rat cDNA (RNB6) that shows high expression in the neonatal brain revealed a member of Ena/VASP family". Biochem. Biophys. Res. Commun. 237 (2): 307–12. doi:10.1006/bbrc.1997.7113. PMID 9268706.
Krause M, Sechi AS, Konradt M, et al. (2000). "Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton". J. Cell Biol. 149 (1): 181–94. doi:10.1083/jcb.149.1.181. PMC 2175102 . PMID 10747096.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi: 10.1073/pnas.160270997 . PMC 16901 . PMID 10931946.
Scott MP, Zappacosta F, Kim EY, et al. (2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1". J. Biol. Chem. 277 (31): 28238–46. doi: 10.1074/jbc.M202783200 . PMID 12029088.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Salazar MA, Kwiatkowski AV, Pellegrini L, et al. (2004). "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton". J. Biol. Chem. 278 (49): 49031–43. doi: 10.1074/jbc.M308104200 . PMID 14506234.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Krause M, Leslie JD, Stewart M, et al. (2004). "Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics". Dev. Cell. 7 (4): 571–83. doi: 10.1016/j.devcel.2004.07.024 . PMID 15469845.
Lafuente EM, van Puijenbroek AA, Krause M, et al. (2004). "RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion". Dev. Cell. 7 (4): 585–95. doi:10.1016/j.devcel.2004.07.021. hdl: 1721.1/83508 . PMID 15469846.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rotter B, Bournier O, Nicolas G, et al. (2005). "AlphaII-spectrin interacts with Tes and EVL, two actin-binding proteins located at cell contacts". Biochem. J. 388 (Pt 2): 631–8. doi:10.1042/BJ20041502. PMC 1138971 . PMID 15656790.
Barzik M, Kotova TI, Higgs HN, et al. (2005). "Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins". J. Biol. Chem. 280 (31): 28653–62. doi: 10.1074/jbc.M503957200 . PMC 1747414 . PMID 15939738.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Bournier O, Kroviarski Y, Rotter B, et al. (2006). "Spectrin interacts with EVL (Enabled/vasodilator-stimulated phosphoprotein-like protein), a protein involved in actin polymerization". Biol. Cell. 98 (5): 279–93. doi: 10.1042/BC20050024 . PMID 16336193.
Bausen M, Fuhrmann JC, Betz H, O'sullivan GA (2006). "The state of the actin cytoskeleton determines its association with gephyrin: role of ena/VASP family members". Mol. Cell. Neurosci. 31 (2): 376–86. doi:10.1016/j.mcn.2005.11.004. PMID 16376568. S2CID 24824029.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000196405 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021262 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10945997-5] Lambrechts A, Kwiatkowski AV, Lanier LM, Bear JE, Vandekerckhove J, Ampe C, Gertler FB (Dec 2000). "cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains". J Biol Chem. 275 (46): 36143–51. doi: 10.1074/jbc.M006274200 . PMID 10945997.

[pmid10993894-6] Klostermann A, Lutz B, Gertler F, Behl C (Jan 2001). "The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain". J Biol Chem. 275 (50): 39647–53. doi: 10.1074/jbc.M006316200 . PMID 10993894.

[entrez-7] "Entrez Gene: EVL Enah/Vasp-like".

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Enah/Vasp-like

Related Research Articles

References

Further reading