Esterified estrogens/methyltestosterone

Last updated
Esterified estrogens /
methyltestosterone
Estrone sulfate.svg
Methyltestosterone.svg
Combination of
Esterified estrogens Estrogen
Methyltestosterone Androgen; Anabolic steroid
Clinical data
Trade names Covaryx, Essian, Estratest, Menogen, Syntest
Other namesEEs/MT
Routes of
administration
By mouth
Drug class Estrogen; Androgen
ATC code
Identifiers
CAS Number

Esterified estrogens/methyltestosterone (EEs/MT), sold under brand names such as Covaryx, Eemt, Essian, Estratest, Menogen, and Syntest, is a hormonal preparation that combines esterified estrogens (EEs) with methyltestosterone (MT) in one tablet and is used in menopausal hormone therapy. [1]

Contents

Medical uses

EEs/MT is used to treat menopausal women who suffer from hot flashes, but do not get relief from estrogen-only therapy.

Available forms

EEs/MT is sold in tablet form, with either 1.25 mg EEs/2.5 mg MT or 0.625 mg EEs/1.25 mg MT available.

Pharmacology

The product is a combination of esterified estrogens, an estrogen, and low-dose methyltestosterone, an androgen/anabolic steroid, in a single tablet.

History

EEs/MT was first marketed in the United States in 1965 by Reid-Provident Laboratories, which as 100% of Reid-Rowell, Inc. stock was acquired by the Belgian pharmaceutical company Solvay in 1986. There has been some controversy surrounding the drug in recent years as to its status with the U.S. Food and Drug Administration.

Solvay sponsored a clinical trial of EEs/MT in the United States to determine whether the product is superior to treatment with esterified estrogens tablets.

EEs/MT was supplied by Solvay. In March 2009 Solvay announced that, based on a variety of business factors, it would discontinue supplying Estratest and Estratest HS tablets, and would stop accepting orders for the product on March 31, 2009.

See also

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Estradiol cypionate/testosterone cypionate

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Estradiol valerate/testosterone enanthate

Estradiol valerate/testosterone enanthate (EV/TE), sold under the brand names Primodian Depot and Ditate among others, is an injectable combination medication of estradiol valerate (EV), an estrogen, and testosterone enanthate (TE), an androgen/anabolic steroid, which is used in menopausal hormone therapy for women. The medication is also used to suppress lactation in postpartum women.

Conjugated estrogens/methyltestosterone

Conjugated estrogens/methyltestosterone (CEEs/MT), sold under the brand name Premarin with Methyltestosterone, is a combination of conjugated estrogens (CEEs), an estrogen, and methyltestosterone (MT), an androgen and anabolic steroid (AAR), which is used in menopausal hormone therapy for women. It contains 0.625 to 1.25 mg CEEs and 5 to 10 mg MT. The medication was marketed by Wyeth-Ayerst. CEEs/MT was previously marketed in the United States and Canada. It remains available only in Paraguay, under the brand names Delitan and Delitan Forte.

Estradiol/drospirenone

Estradiol/drospirenone (E2/DRSP), sold under the brand name Angeliq, is a combination of estradiol (E2), an estrogen, and drospirenone (DRSP), a progestin, antimineralocorticoid, and antiandrogen, which is used in menopausal hormone therapy, specifically the treatment of menopausal syndrome and osteoporosis, in postmenopausal women. It is taken by mouth and contains 0.5 to 1 mg E2 and 0.25 to 0.5 mg DRSP per tablet. The medication was approved in the United States in 2005. It is marketed widely throughout the world.

Estradiol/dydrogesterone

Estradiol/dydrogesterone (E2/DYD), sold under the brand name Femoston among others, is a combination of estradiol (E2), an estrogen, and dydrogesterone (DYD), a progestin, which is used in menopausal hormone therapy, specifically to treat and prevent hot flashes and osteoporosis, in postmenopausal women. It is taken by mouth and contains 0.5, 1, or 2 mg E2 and 2.5, 5, 10, or 20 mg DYD per tablet. The medication is marketed widely throughout the world. It is not available in the United States or Canada.

Ethinylestradiol/desogestrel Progestogens and estrogens systemic contraceptives, sequential preparations

Desogestrel/ethinylestradiol (EE/DSG), sold under the brand name Marvelon among others, is a fixed-dose combination of desogestrel (DSG), a progestin, and ethinylestradiol (EE), an estrogen, which is used as a birth control pill to prevent pregnancy in women. It is taken by mouth.

Ethinylestradiol/gestodene

Ethinylestradiol/gestodene (EE/GSD), sold under the brand names Femodene and Minulet among others, is a combination of ethinylestradiol (EE), an estrogen, and gestodene (GSD), a progestin, which is used as a birth control pill to prevent pregnancy in women. It is taken by mouth and contains 20 or 30 μg EE and 0.075 mg GSD per tablet. EE/GSD is marketed widely throughout the world.

References

  1. "Esterified Estrogens And Methyltestosterone (Oral Route)". Mayo Clinic. Mayo Foundation for Medical Education and Research.