Fluorothymidine may refer to:
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Thymidine kinase is an enzyme, a phosphotransferase : 2'-deoxythymidine kinase, ATP-thymidine 5'-phosphotransferase, EC 2.7.1.21. It can be found in most living cells. It is present in two forms in mammalian cells, TK1 and TK2. Certain viruses also have genetic information for expression of viral thymidine kinases. Thymidine kinase catalyzes the reaction:
The standardized uptake value (SUV) is a nuclear medicine term, used in positron emission tomography (PET) as well as in modern calibrated Single Photon Emission Tomography (SPECT) imaging for a (semi)quantitative analysis. Its use is particularly common in the analysis of [18F]fluorodeoxyglucose ([18F]FDG) images of cancer patients. It can also be used with other PET agents especially when no arterial input function is available for more detailed pharmacokinetic modeling. Otherwise measures like the fractional uptake rate (FUR) or parameters from more advanced pharmacokinetic modeling may be preferable.
Alovudine (fluorothymidine) is an antiviral agent which was being developed by Medivir. It was discontinued after a Phase II trial in 2005 due to toxicity. It is a DNA polymerase inhibitor.
Amira is a software platform for 3D and 4D data visualization, processing, and analysis. It is being actively developed by Thermo Fisher Scientific in collaboration with the Zuse Institute Berlin (ZIB), and commercially distributed by Thermo Fisher Scientific.
Fluorothymidine F-18 (FLT) is a tumor-specific PET tracer and radiopharmaceutical. It is a version of alovudine in which the fluorine atom has been isotopically labeled as fluorine-18. FLT is suitable for monitoring how tumors respond to cytostatic therapy. FLT accumulates in proliferating cells where it indicates the activity of the enzyme thymidine kinase. Cell division can be characterized by the activity of that enzyme. FLT is phosphorylated as though it were thymidine, and is subsequently incorporated into DNA. Thymidine is essential for DNA replication. Considering that FLT lacks a 3′-hydroxy group, transcription of DNA is impeded following incorporating of FLT. FLT indicates changes in tumor cell proliferation by tracking the restoration of nucleosides from degenerated DNA.
3'-Fluoro-3'-deoxythymidine may refer to:
The molecular formula C10H13FN2O4 may refer to:
Rabacfosadine, marketed by VetDC under the brand name Tanovea-CA1, is a guanine nucleotide analog used for the treatment of lymphoma in dogs. The drug is conditionally approved by the U.S. Food and Drug Administration under application number 141-475 for use in treating canine lymphoma pending a full demonstration of effectiveness. Originally developed by Gilead Sciences as GS-9219, rabacfosadine is no longer being pursued for use in the treatment of lymphoma in humans.