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In chemistry, a leaving group is defined by the IUPAC as an atom or group of atoms that detaches from the main or residual part of a substrate during a reaction or elementary step of a reaction. However, in common usage, the term is often limited to a fragment that departs with a pair of electrons in heterolytic bond cleavage. In this usage, a leaving group is a less formal but more commonly used synonym of the term nucleofuge. In this context, leaving groups are generally anions or neutral species, departing from neutral or cationic substrates, respectively, though in rare cases, cations leaving from a dicationic substrate are also known.
Charles Friedel was a French chemist and mineralogist.
James Mason Crafts was an American chemist, mostly known for developing the Friedel–Crafts alkylation and acylation reactions with Charles Friedel in 1876.
The Friedel–Crafts reactions are a set of reactions developed by Charles Friedel and James Crafts in 1877 to attach substituents to an aromatic ring. Friedel–Crafts reactions are of two main types: alkylation reactions and acylation reactions. Both proceed by electrophilic aromatic substitution.
Acetyl chloride is an acyl chloride derived from acetic acid. It belongs to the class of organic compounds called acid halides. It is a colorless, corrosive, volatile liquid. Its formula is commonly abbreviated to AcCl.
Edmond-Charles Genêt, also known as Citizen Genêt, was the French envoy to the United States appointed by the Girondins during the French Revolution. His actions on arriving in the United States led to a major political and international incident, which was termed the Citizen Genêt affair. Because of his actions, President George Washington asked the French government to recall him. The Mountain, having risen to power at the same time, replaced Genêt and issued a warrant for his arrest. Fearing for his life, Genêt asked for asylum in America, which was granted by Washington. Genêt stayed in the United States until his death. Historian Carol Berkin argues that the Genêt affair bolstered popular respect for the president and strengthened his role in dealing with foreign affairs.
In organic chemistry, a sulfone is a organosulfur compound containing a sulfonyl functional group attached to two carbon atoms. The central hexavalent sulfur atom is double-bonded to each of two oxygen atoms and has a single bond to each of two carbon atoms, usually in two separate hydrocarbon substituents.
The Fries rearrangement, named for the German chemist Karl Theophil Fries, is a rearrangement reaction of a phenolic ester to a hydroxy aryl ketone by catalysis of Lewis acids.
The Blanc chloromethylation is the chemical reaction of aromatic rings with formaldehyde and hydrogen chloride to form chloromethyl arenes. The reaction is catalyzed by Lewis acids such as zinc chloride. The reaction was discovered by Gustave Louis Blanc (1872-1927) in 1923
Friedel or Friedl is a Southern German diminutive variation of the surname Fried - or alternately, a diminutive of Elfriede - and may refer to:
The Hofmann–Martius rearrangement in organic chemistry is a rearrangement reaction converting an N-alkylated aniline to the corresponding ortho and / or para aryl-alkylated aniline. The reaction requires heat, and the catalyst is an acid like hydrochloric acid.
Georges Friedel was a French mineralogist and crystallographer.
Jacques Lob was a French comic book creator, known for several comics creations, including Superdupont.
Chimie ParisTech, founded in 1896 within the University of Paris, is an engineering school and a constituent college of PSL Research University specialised in chemical science. It is located in the 5th arrondissement of Paris.
Friedel's salt is an anion exchanger mineral belonging to the family of the layered double hydroxides (LDHs). It has affinity for anions as chloride and iodide and is capable of retaining them to a certain extent in its crystallographical structure.
The Minisci reaction is a named reaction in organic chemistry. It is a nucleophilic radical substitution to an electron deficient aromatic compound, most commonly the introduction of an alkyl group to a nitrogen containing heterocycle. The reaction was published in 1971 by F. Minisci. In the case of N-Heterocycles, the conditions must be acidic to ensure protonation of said heterocycle. A typical reaction is that between pyridine and pivalic acid with silver nitrate, sulfuric acid and ammonium persulfate to form 2-tert-butylpyridine. The reaction resembles Friedel-Crafts alkylation but with opposite reactivity and selectivity.
Jacques Friedel ForMemRS was a French physicist and material scientist.
Electrophilic aromatic substitution is an organic reaction in which an atom that is attached to an aromatic system is replaced by an electrophile. Some of the most important electrophilic aromatic substitutions are aromatic nitration, aromatic halogenation, aromatic sulfonation, and alkylation and acylation Friedel–Crafts reaction.
Edmond Jacques Eckel (1845–1934) was an architect in Missouri. One of his firms was Eckel & Mann. Eckel's name has been spelled with variations including Edmund rather than Edmond and with Jacques spelled as Jaques.