Hi-C may refer to:
Kinetics may refer to:
Module, modular and modularity may refer to the concept of modularity. They may also refer to:
Progressive may refer to:
Gp or GP may refer to:
CH, Ch, cH, or ch may refer to:
JB or J.B. may refer to:
Conformation generally means structural arrangement and may refer to:
Roach may refer to:
Offset or Off-Set may refer to:
Chop, CHOP, Chops, or CHOPS may refer to:
Stitch, Stitches or Stitched may refer to:
The adjective iconic may describe:
Median may refer to:
Stripe, striped, or stripes may refer to:
The Almighty is an Abrahamic term for God.
3C may refer to:
High fidelity or hi-fi is most commonly a term for the high-quality reproduction of sound or images.
Chromosome conformation capture techniques are a set of molecular biology methods used to analyze the spatial organization of chromatin in a cell. These methods quantify the number of interactions between genomic loci that are nearby in 3-D space, but may be separated by many nucleotides in the linear genome. Such interactions may result from biological functions, such as promoter-enhancer interactions, or from random polymer looping, where undirected physical motion of chromatin causes loci to collide. Interaction frequencies may be analyzed directly, or they may be converted to distances and used to reconstruct 3-D structures.
Single cell epigenomics is the study of epigenomics in individual cells by single cell sequencing. Since 2013, methods have been created including whole-genome single-cell bisulfite sequencing to measure DNA methylation, whole-genome ChIP-sequencing to measure histone modifications, whole-genome ATAC-seq to measure chromatin accessibility and chromosome conformation capture.
Hi-C is a high-throughput genomic and epigenomic technique first described in 2009 by Lieberman-Aiden et al. to capture chromatin conformation. In general, Hi-C is considered as a derivative of a series of chromosome conformation capture technologies, including but not limited to 3C, 4C, and 5C. Hi-C comprehensively detects genome-wide chromatin interactions in the cell nucleus by combining 3C and next-generation sequencing (NGS) approaches and has been considered as a qualitative leap in C-technology development and the beginning of 3D genomics.