History of ME/CFS

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Royal Free Hospital in London, where myalgic encephalomyelitis came to prominent attention in 1955 Royal Free Hospital, Hampstead - geograph.org.uk - 275921.jpg
Royal Free Hospital in London, where myalgic encephalomyelitis came to prominent attention in 1955

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) has a long history with an evolution in medical understanding, diagnoses and social perceptions.

Contents

In the early 19th century, the diagnosis of neuresthenia was popular, which had overlaps with current ME/CFS criteria. Various outbreaks of enigmatic disease occurred in the early 20th century, variably known as atypical poliomyelitis, Akureyri disease or epidemic neuromyasthenia.

After an outbreak in the Royal Free Hospital in London, the disease became known as benign myalgic encephalomyelitis. Controversy erupted when psychiatrists who had not spoken to any of the patients called the outbreak a case of "mass hysteria". The first case definition of ME was published in 1986, and the first definition of CFS in 1988.

Timeline

19th century

Several descriptions of illness resembling ME/CFS have been reported for at least 200 years. [1]

In the 19th century, neurologist George Miller Beard popularised the concept of neurasthenia, with symptoms including fatigue, anxiety, headache, impotence, neuralgia and depression. [2] This concept remained popular well into the 20th century, eventually coming to be seen as a behavioural rather than physical condition, with a diagnosis that excluded postviral syndromes. Neurasthenia has largely been abandoned as a medical diagnosis. [3] The ICD-10 system of the World Health Organization categorized neurasthenia under (F48 Other neurotic disorders) which specifically excluded chronic fatigue syndrome. [4] The current version of ICD, ICD-11, does not include neurasthenia and "deprecates" its use.

Outbreaks in the 20th century

A United States Public Health Service (USPHS) official, Alexander Gilliam, described an illness that resembled poliomyelitis, after interviewing patients and reviewing records of one of several clusters which had occurred in Los Angeles, during 1934. [5] The Los Angeles County Hospital outbreak included all or most of its nurses and doctors. [6] Gilliam called the outbreak "atypical poliomyelitis" and described the symptoms as: rapid muscle weakness, vasomotor instability, clonic twitches and cramps, ataxia, severe pain (usually aggravated by exercise), neck and back stiffness, menstrual disturbance and dominant sensory involvement.[ citation needed ]

There was a cluster of "encephalitis" cases in 1936, at a convent in Wisconsin, amongst novices and convent candidates. The following year two towns in Switzerland had outbreaks of "abortive poliomyelitis" , and 73 Swiss soldiers were given the same diagnosis in 1939. Outbreaks in Iceland were called "Akureyri disease" or "simulating poliomyelitis" and were later called "Iceland disease." [6] 800 people in Adelaide, Australia became ill during 1949–1951 with a disease "resembling poliomyelitis." Two smaller clusters in the United States during 1950 were diagnosed as "Epidemic neuromyasthenia" and "resembling Iceland disease simulating acute anterior poliomyelitis." Additional outbreaks of poliomyelitis-like "mystery diseases" occurred from the 1950s through the 1980s, in Denmark, the United States, South Africa, and Australia, among others. [6]

Several outbreaks of a polio-resembling illness occurred in Britain in the 1950s. [7] A 1955 outbreak at the Royal Free Hospital Group was later called "Royal Free disease" or "benign myalgic encephalomyelitis". [8] [9] The term "benign myalgic encephalomyelitis" was selected to represent the lack of mortality, the severe muscle pain, symptoms suggesting damage to the nervous system, and to the assumed inflammation involved in the illness. [10] Icelandic physician Björn Sigurðsson disapproved of the name, stating that the illness is rarely benign, does not always cause muscle pain, and is possibly never encephalomyelitic. [11]

After the Royal Free Hospital outbreak, a disorder with similar symptoms was found among the general population and the epidemic form came to be considered the exception.[ citation needed ] Pathology findings, both in monkeys [12] and in rare human casualties, [13] led to the conclusion that the disorder was caused by inflammation of the brain and the spinal cord, particularly the afferent nerve roots, perhaps with neuroimmune etiology. [14]

Psychological framing (1960s and 1970s)

In the 1960s and 1970s, chronic fatigue symptoms were often attributed to chronic brucellosis, but typically people were seen as having psychiatric disorders, in particular depression. [6] Epidemic cases of benign myalgic encephalomyelitis were called mass hysteria by psychiatrists McEvedy and Beard in 1970, [15] provoking criticism in letters to the editor of the British Medical Journal by outbreak researchers, attending physicians, and physicians who fell ill. [16] [17] [18] [19] [20] [21] [22] [23] [24] The psychiatrists were faulted for not adequately investigating the patients they described, [25] and their conclusions have been refuted. [3] [26] [27] In 1978 a symposium held at the Royal Society of Medicine (RSM) concluded that "epidemic myalgic encephalomyelitis" was a distinct disease entity with a clear organic basis. [28]

Despite the criticism, the paper By McEvedy and Beard had a large impact and the view of ME as a psychosomatic disease became prevalent for almost 50 years. [29]

Case definitions (1986 onwards)

In 1986, Melvin Ramsay published the first diagnostic criteria for ME, in which the condition was characterized by: 1) muscle fatiguability in which, even after minimal physical effort, three or more days elapse before full muscle power is restored; 2) extraordinary variability or fluctuation of symptoms, even in the course of one day; and 3) chronicity. [30] By 1988, the continued work of Ramsay had demonstrated that, although the disease rarely resulted in mortality, it was often severely disabling. [10] : 28–29  Because of this, Ramsay proposed that the prefix "benign" be dropped. [31] [32] [33]

The illness gained national attention in the United States when the popular magazine Hippocrates ran a cover story of an epidemic at Lake Tahoe, Nevada, in the mid-1980s. [34] The designation Chronic Epstein–Barr Virus was in use in the U.S., [35] [36] but the magazine used the term "Raggedy Ann Syndrome" to note the fatigue and loss of muscle power patients felt. [37] Researchers investigating the Lake Tahoe cluster did not find evidence that EBV was involved, and they proposed the name "chronic fatigue syndrome", describing a main symptom of the illness. [38] [39] They published the first working case definition for CFS in 1988. [40] Research increased considerably, and more so after the criteria were relaxed in 1994. [41]

In 1990, researchers presented evidence they found DNA sequences very similar to the human HTLV-II retrovirus in some CFS patients, at a conference in Kyoto, Japan. [42] [43] Their study was later published in the Proceedings of the National Academy of Sciences . [44] A reporter on Prime Time Live stated the announcement made headlines all over the world. The CDC first ignored their findings, [45] then later conducted a study and published a paper that refuted the hypothesis. [46]

In the United Kingdom, the Chief Medical Officer Kenneth Calman requested a report from the medical Royal Colleges in 1996. This led to the publication of a joint report in which the term "chronic fatigue syndrome" was found to be most representative. [47] This was followed in 2002 by a further report by the new CMO, Liam Donaldson. [48]

The U.S. Centers for Disease Control & Prevention (CDC) recognize CFS as a serious illness, and launched a campaign in June 2006 to raise public and medical awareness about it. [49] [50]

XMRV controversy

A 2009 study published in the journal Science reported an association between a retrovirus xenotropic murine leukemia virus–related virus (XMRV) and CFS. The editors of Science subsequently attached an "Editorial Expression of Concern" to the report, to the effect that the validity of the study "is now seriously in question". [51] and in September 2011, the authors published a "Partial Retraction" of their 2009 findings; [52] this was followed by a full retraction by the magazine's Editor in Chief, after the authors failed to agree on a full retraction statement. [53] Also in September 2011, the Blood XMRV Scientific Research Working Group published a report, which concluded "that currently available XMRV/P-MLV assays, including the assays employed by the three participating laboratories that previously reported positive results on samples from CFS patients and controls (2, 4), cannot reproducibly detect direct virus markers (RNA, DNA, or culture) or specific antibodies in blood samples from subjects previously characterized as XMRV/P-MLV positive (all but one with a diagnosis of CFS) or healthy blood donors." [54] In December 2011, the Proceedings of the National Academy of Sciences published a similar retraction for an August 2010 paper. [55] Some members of the patient community, who had viewed the XMRV findings as a source of hope for a possible cure, initially reacted negatively when the papers were called into question. One UK researcher reported verbal abuse after publishing an early paper indicating that the XMRV studies were flawed. [56]

International classifications

The World Health Organization's (WHO) International Classification of Diseases (ICD), mandates the international classifications of diseases to allow comparison of health and health fields across countries and throughout the world. [57] Not all terms appear in the tabular list (Volume 1), and many more terms are listed in the alphabetic index (Volume 3) of the ICD. [58]

ICD-8

Since its introduction into the eighth edition of the WHO ICD-8 in 1969 (code 323), (Benign) myalgic encephalomyelitis has been classified as a disease of the central nervous system. [59]

ICD-9

The term "benign myalgic encephalomyelitis" appears in the 1975 ICD-9 alphabetic index, and references code 323.9, Encephalitis of unspecified cause. [60] The code 323.9 did not include reference to postviral syndrome. The term “postviral syndrome” was classified to code 780.7, Malaise and fatigue, in Chapter 16, Symptoms, signs and ill-defined conditions. [58]

The name Chronic Fatigue Syndrome has been attributed to the US Centers for Disease Control 1988 research case definition for the illness, "Chronic fatigue syndrome: a working case definition". [38] [40] Chronic Fatigue Syndrome (CFS) was added to ICD-9 after 1988 and listed under code 780.71, Symptoms Signs and Ill-defined Conditions.[ citation needed ]

ICD-9-CM

Since 1979 the U.S. has used a clinical modification of WHO's ICD 9th revision (ICD-9-CM), [58] and ME is under index: "Encephalomyelitis (chronic) (granulomatous) (hemorrhagic necrotizing, acute) (myalgic, benign) (see also Encephalitis) 323.9." [61]

For CFS, a modification to the alphabetic index was made, effective on October 1, 1991, to direct users to code 780.7, Malaise and fatigue, the same code used to identify cases of postviral syndrome. In 1998, a new five-digit code included 780.71, Chronic fatigue syndrome, consistent with the WHO version of ICD-9. [58] Chronic fatigue syndrome is classified in tabular list: "Symptoms, Signs and Ill-Defined Conditions," under the sub-heading of "General Symptoms". [62]

ICD-10

CFS is not included as a coded term in the 1992 ICD-10, WHO created a new category G93, Other disorders of brain, in Chapter VI, Diseases of the Nervous System, and created a new code G93.3, post-viral fatigue syndrome (PVFS), a condition which was previously in the symptom chapter of ICD-9. WHO also moved benign myalgic encephalomyelitis to G93.3, subordinate to PVFS. The alphabetic index contains other terms, such as chronic fatigue syndrome, to which WHO assigned the same code. [58] [63]

ICD-10-CM

The 2010 version of the ICD-10-CM separates CFS and Postviral fatigue syndrome into mutually exclusive categories. "Chronic fatigue, unspecified | Chronic fatigue syndrome not otherwise specified" appears in Chapter XVIII under R53.82. "Postviral fatigue syndrome | benign myalgic encephalomyelitis" appears in Chapter VI under G93.3. [64] The Chronic Fatigue Syndrome Advisory Committee (CFSAC) had previously recommended CFS to be placed under the same neurological code as ME and PVFS, G93.3. [65]

The 2023 update to the ICD-10-CM added a specific code for ME/CFS, G93.32, giving CFS a code separate from unspecified chronic fatigue. [66]

ICD-11

ICD-11 includes Chronic fatigue syndrome and Myalgic encephalomyelitis under Post-viral fatigue syndrome, (8E49), within the classification; Other disorders of the nervous system. Excluded is the condition of fatigue (MG22). Numerous index terms are presented, which represent current and historical names of the illness. [67]

Historical naming

A range of both theorised and confirmed medical entities and naming conventions have appeared historically in the medical literature dealing with ME and CFS. These include:

Related Research Articles

<span class="mw-page-title-main">Fatigue</span> Range of afflictions, usually associated with physical or mental weakness

Fatigue describes a state of tiredness, exhaustion or loss of energy.

Neurasthenia is a term that was first used as early as 1829 for a mechanical weakness of the nerves. It became a major diagnosis in North America during the late nineteenth and early twentieth centuries after neurologist George Miller Beard reintroduced the concept in 1869.

<span class="mw-page-title-main">ME Association</span> UK charitable organization

The ME Association is a UK health charitable organization that provides information, advocacy, and services to persons and families affected by ME/CFS, and raises funds for research into ME/CFS. It has been reported to be one of the two largest UK charities for ME/CFS.

A functional symptom is a medical symptom with no known physical cause. In other words, there is no structural or pathologically defined disease to explain the symptom. The use of the term 'functional symptom' does not assume psychogenesis, only that the body is not functioning as expected. Functional symptoms are increasingly viewed within a framework in which 'biological, psychological, interpersonal and healthcare factors' should all be considered to be relevant for determining the aetiology and treatment plans.

Management of ME/CFS focusses on symptoms management, as no treatments that address the root cause of the illness are available. Pacing, or regulating one's activities to avoid triggering worse symptoms, is the most common management strategy for post-exertional malaise. Clinical management varies widely, with many patients receiving combinations of therapies.

<span class="mw-page-title-main">Controversies related to ME/CFS</span> Controversies and issues related to ME/CFS

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is an illness with a history of controversy. Although it is classified as an organic disease, it was historically assumed to be psychosocial, and a minority of medical professionals still hold this view. The pathophysiology of ME/CFS remains unclear, there exists many competing diagnostic criteria, and some proposed treatments are controversial. There is a lack of awareness about the condition, which has led to substantiated accusations of patient neglect and harm.

<span class="mw-page-title-main">Clinical descriptions of ME/CFS</span> Case definitions of the illness

Clinical descriptions of ME/CFS vary. Different groups have produced sets of diagnostic criteria that share many similarities. The biggest differences between criteria are whether post-exertional malaise (PEM) is required, and the number of symptoms needed.

The Lightning Process (LP) is a three-day personal training programme developed and trademarked by British osteopath Phil Parker. It makes unsubstantiated claims to be beneficial for various conditions, including ME/CFS, depression and chronic pain.

Graded exercise therapy (GET) is a programme of physical activity that starts very slowly and gradually increases over time, intended as a treatment for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Most public health bodies, including the CDC and NICE, consider it ineffective, and its safety is disputed. However, GET still enjoys support among a minority of clinicians and organizations.

David Sheffield Bell is an American physician who has done extensive research on the clinical aspects of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). He has also conducted evaluations and research in pediatric ME/CFS and written numerous articles about the condition.

Daniel Peterson is an American physician in private practice in the state of Nevada, and has been described as a "pioneer" in the treatment of chronic fatigue syndrome (CFS). He graduated from the University of Rochester School of Medicine, Rochester, New York, in 1976 and was an intern and resident at the University of Utah Medical Center from 1976 to 1979. In 1979, he became a diplomate of the American Board of Internal Medicine. He is president of Sierra Internal Medicine of Incline Village, established in 1981.

<span class="mw-page-title-main">Myalgic encephalomyelitis/chronic fatigue syndrome</span> Chronic medical condition

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious long-term illness. People with ME/CFS experience a profound fatigue that does not go away with rest, sleep issues and problems with memory or concentration. They are able to do much less than before they became ill. Further common symptoms include dizziness, nausea and pain. The hallmark symptom is a worsening of the illness hours to days after minor physical or mental activity. This "crash" can last less than a day to several months.

Akureyri disease is the name used for an outbreak of what is now recognised as myalgic encephalomyelitis/chronic fatigue syndrome in Iceland. A disease with symptoms similar to poliomyelitis broke out in the town of Akureyri in northern Iceland in the winter of 1948–1949. The center of the epidemic was in the main secondary boarding school. The predominant symptoms were tiredness and exhaustion. Since the outbreak of the disease, those affected were often thought to have a psychiatric disorder such as hysteria.

Rosamund Vallings is a medical doctor, known as one of the leading authorities on Chronic Fatigue Syndrome (ME/CFS) in New Zealand.

<span class="mw-page-title-main">Post-exertional malaise</span> Worsening of symptoms with activity

Post-exertional malaise (PEM), sometimes referred to as post-exertional symptom exacerbation (PESE) or post-exertional neuroimmune exhaustion (PENE), is a worsening of symptoms that occurs after minimal exertion. It is the hallmark symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and common in long COVID and fibromyalgia. PEM is often severe enough to be disabling, and is triggered by ordinary activities that healthy people tolerate. Typically, it begins 12–48 hours after the activity that triggers it, and lasts for days, but this is highly variable and may persist much longer. Management of PEM is symptom-based, and patients are recommended to pace their activities to avoid triggering PEM.

Idiopathic chronic fatigue (ICF) or chronic idiopathic fatigue or insufficient/idiopathic fatigue is a term used for cases of unexplained fatigue that have lasted at least six consecutive months and which do not meet the criteria for Myalgic Encephalomyelitis/chronic fatigue syndrome. Such fatigue is widely understood to have a profound effect on the lives of patients who experience it.

<span class="mw-page-title-main">2-day CPET</span> Medical test for post-exertional malaise

A 2-day CPET is a cardiopulmonary exercise test given on two successive days to measure the effect of post-exertional malaise (PEM) on a patient's ability to exercise. PEM is a cardinal symptom of myalgic encephalomyelitis/chronic fatigue syndrome and is common in long COVID as well.

Post-acute infection syndromes (PAISs) or post-infectious syndromes are medical conditions characterized by symptoms attributed to a prior infection. While it is commonly assumed that people either recover or die from infections, long-term symptoms—or sequelae—are a possible outcome as well. Examples include long COVID, chronic fatigue syndrome (ME/CFS), and post-Ebola virus syndrome. Common symptoms include post-exertional malaise (PEM), severe fatigue, neurocognitive symptoms, flu-like symptoms, and pain. The pathology of most of these conditions is not understood and management is generally symptomatic.

Andrew Melvin Ramsay (1901–1990) was a British physician, who is known for his research and advocacy on myalgic encephalomyelitis (ME), a chronic disease causing muscle weakness and cognitive dysfunction. Ramsay worked as a consultant at the Royal Free Hospital in London during a mysterious 1955 disease outbreak of what later became known as ME. He studied the disease and similar outbreaks elsewhere. Work by Ramsay showed that although ME seldom caused death, the disease could be highly disabling.

Carmen Scheibenbogen is a German immunologist who is the acting director of the Institute for Medical Immunology of the Charité university hospital in Berlin. She specialises in hematology, oncology and immunology. She leads the Outpatient Clinic for Immunodeficiency and the Fatigue Centre at the Charité hospital. She is one of the few doctors specialised in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in Germany, and also researches long COVID.

References

  1. ↑ Lorusso L, Mikhaylova SV, Capelli E, Ferrari D, Ngonga GK, Ricevuti G (February 2009). "Immunological aspects of chronic fatigue syndrome". Autoimmun Rev. 8 (4): 287–91. doi:10.1016/j.autrev.2008.08.003. PMID   18801465.
  2. ↑ Beard, G (1869). "Neurasthenia, or nervous exhaustion". The Boston Medical and Surgical Journal. 80 (13): 217–21. doi:10.1056/NEJM186904290801301.
  3. 1 2 Evangard B, Schacterie RS, Komaroff AL (November 1999). "Chronic fatigue syndrome: new insights and old ignorance". Journal of Internal Medicine. 246 (5): 455–69. doi:10.1046/j.1365-2796.1999.00513.x. PMID   10583715 . Retrieved June 25, 2009.[ dead link ]
  4. ↑ WHO (2007). "Chapter V Mental and behavioural disorders (F00-F99)". ICD-10. Retrieved October 9, 2009.
  5. ↑ Gilliam, AG (1938). "Epidemiological study on an epidemic, diagnosed as poliomyelitis, occurring among the personnel of Los Angeles County General Hospital during the summer of 1934". United States Treasury Department Public Health Service Public Health Bulletin. 240. Washington, DC: United States Government Printing Office: 1–90.
  6. 1 2 3 4 Roberto Patarca-Montero (2004). Medical Etiology, Assessment, and Treatment of Chronic Fatigue and Malaise. Haworth Press. pp. 6–7. ISBN   0-7890-2196-X.
  7. 1 2 A. Melvin Ramsay (1986). Postviral Fatigue Syndrome. The saga of Royal Free disease. London: Gower. ISBN   0-906923-96-4.
  8. ↑ The Medical Staff Of The Royal Free Hospital (1957). "An outbreak of encephalomyelitis in the Royal Free Hospital Group, London, in 1955". Br Med J. 2 (5050): 895–904. doi:10.1136/bmj.2.5050.895. PMC   1962472 . PMID   13472002.
  9. ↑ (No authors listed) (1956). "A new clinical entity?". Lancet. 270 (6926): 789–90. doi:10.1016/S0140-6736(56)91252-1. PMID   13320887.
  10. 1 2 Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome; Board on the Health of Select Populations; Institute of Medicine (February 10, 2015). Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness (PDF). PMID   25695122. Archived (PDF) from the original on January 20, 2017. Retrieved July 28, 2020.
  11. ↑ Acheson ED (April 1959). "The clinical syndrome variously called benign myalgic encephalomyelitis, Iceland disease and epidemic neuromyasthenia". The American Journal of Medicine. 26 (4): 569–595. CiteSeerX   10.1.1.534.4761 . doi:10.1016/0002-9343(59)90280-3. PMID   13637100.
  12. ↑ Pellew RA, Miles JA (September 1955). "Further investigations on a disease resembling poliomyelitis seen in Adelaide". Med. J. Aust. 2 (13): 480–82. doi:10.5694/j.1326-5377.1955.tb48805.x. PMID   13272481. S2CID   45427244.
  13. ↑ Wallis AL (1957). An investigation into an unusual illness seen in epidemic and sporadic form in a general practice in Cumberland in 1955 and subsequent years (M.D. thesis). Edinburgh University.
  14. ↑ Richardson J (2002). "Myalgic encephalomyelitis: guidelines for doctors". Journal of Chronic Fatigue Syndrome. 10 (1): 65–80. doi:10.1300/j092v10n01_06.
  15. ↑ McEvedy CP, Beard AW (1970). "Concept of Benign Myalgic Encephalomyelitis". British Medical Journal. 1 (5687): 11–15. doi:10.1136/bmj.1.5687.11. PMC   1700895 . PMID   5411596.
  16. ↑ Scott BD (January 1970). "Epidemic malaise". Br Med J. 1 (5689): 170–75. doi:10.1136/bmj.1.111.170. PMC   1699088 . PMID   5370039.
  17. ↑ N. D. Compston; H. E. Dimsdale; A. M. Ramsay; A. T. Richardson (February 1970). "Epidemic malaise". Br Med J. 1 (5692): 362–63. doi:10.1136/bmj.1.5692.362-a. PMC   1699022 .
  18. ↑ E. D. Acheson (February 1970). "Epidemic Malaise". Br Med J. 1 (5692): 363–34. doi:10.1136/bmj.1.5692.363-b. PMC   1698971 .
  19. ↑ Gosling PH (February 1970). "Epidemic malaise". Br Med J. 1 (5694): 499–500. doi:10.1136/bmj.1.5694.499-b. PMC   1699452 . PMID   5435167.
  20. ↑ Purke GJ (February 1970). "Epidemic malaise". Br Med J. 1 (5694): 500. doi:10.1136/bmj.1.5694.500. PMC   1699458 . PMID   5435168.
  21. ↑ Hopkins EJ (February 1970). "Epidemic malaise". Br Med J. 1 (5694): 500–01. doi:10.1136/bmj.1.5694.500-a. PMC   1699426 . PMID   5435169.
  22. ↑ Galpine JF (February 1970). "Epidemic malaise". Br Med J. 1 (5694): 501. doi:10.1136/bmj.1.5694.501. PMC   1699416 . PMID   5435170.
  23. ↑ Poskanzer DC (May 1970). "Epidemic malaise". Br Med J. 2 (5706): 420–21. doi:10.1136/bmj.2.5706.420-b. PMC   1700311 . PMID   5420612.
  24. ↑ Parish JG (July 1970). "Epidemic malaise". Br Med J. 3 (5713): 47–48. doi:10.1136/bmj.3.5713.47-c. PMC   1700986 . PMID   4316803.
  25. ↑ Hooper M (2006). "Myalgic encephalomyelitis: a review with emphasis on key findings in biomedical research". J Clin Pathol. 60 (5): 466–71. doi:10.1136/jcp.2006.042408. PMC   1994528 . PMID   16935967.
  26. ↑ David AS, Wessely S, Pelosi AJ (March 1988). "Postviral fatigue syndrome: time for a new approach". Br Med J (Clin Res Ed). 296 (6623): 696–99. doi:10.1136/bmj.296.6623.696. PMC   2545306 . PMID   3128374.
  27. ↑ Stricklin A, Sewell M, Austad C (January 1990). "Objective measurement of personality variables in epidemic neuromyasthenia patients". S. Afr. Med. J. 77 (1): 31–34. PMID   2294610.
  28. ↑ [No authors listed] (June 3, 1978). "Epidemic myalgic encephalomyelitis". Br Med J. 1 (6125): 1436–37. doi:10.1136/bmj.1.2791.1436-a. PMC   1604957 . PMID   647324.
  29. ↑ Wotherspoon, Nathalie (2021). Exploring The Contested Diagnosis Of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (PDF). University of Sheffield. p. 139.
  30. ↑ Ramsay AM (1988). Myalgic encephalomyelitis and postviral fatigue states (Second ed.).
  31. ↑ Wojcik W, Armstrong D, Kanaan R (June 2011). "Chronic fatigue syndrome: labels, meanings and consequences". Journal of Psychosomatic Research. 70 (6): 500–504. doi:10.1016/j.jpsychores.2011.02.002. PMID   21624573.
  32. ↑ Ramsey AM, David AS, Wessely S, Pelosi AJ, Dowsett EG (July 1988). "Myalgic encephalomyelitis, or what?". Lancet. 2 (8602): 100–101. doi:10.1016/s0140-6736(88)90028-1. PMID   2898668. S2CID   24860444.
  33. ↑ Ramsay AM, Dowsett EG, Dadswell JV, Lyle WH, Parish JG (May 1977). "Icelandic disease (benign myalgic encephalomyelitis or Royal Free disease)". British Medical Journal. 1 (6072): 1350. doi:10.1136/bmj.1.6072.1350-a. PMC   1607215 . PMID   861618.
  34. ↑ Johnson, Hilary (1996). Osler's Web: inside the labyrinth of the chronic fatigue syndrome epidemic. New York: Penguin Books. p. 24. ISBN   0-595-34874-2.
  35. ↑ Jones J, Ray C, Minnich L, Hicks M, Kibler R, Lucas D (1985). "Evidence for active Epstein-Barr virus infection in patients with persistent, unexplained illnesses: elevated anti-early antigen antibodies". Ann Intern Med. 102 (1): 1–7. doi:10.7326/0003-4819-102-1-. PMID   2578266.
  36. ↑ Straus S, Tosato G, Armstrong G, Lawley T, Preble O, Henle W, Davey R, Pearson G, Epstein J, Brus I (1985). "Persisting illness and fatigue in adults with evidence of Epstein-Barr virus infection". Ann Intern Med. 102 (1): 7–16. doi:10.7326/0003-4819-102-1-7. PMID   2578268.
  37. ↑ Day W (1987). "Raggedy Ann syndrome". Hippocrates: July/August, cover story.
  38. 1 2 Sharpe, Michael; Frankie Campling (2000). Chronic Fatigue Syndrome (CFS/ME): TheFacts. Oxford: Oxford Press. pp. 14, 15. ISBN   0-19-263049-0 . Retrieved April 2, 2008.
  39. ↑ Packard RM, Berkelman RL, Brown PJ, Frumkin H (2004). Emerging Illnesses and Society. JHU Press. pp.  156. ISBN   0-8018-7942-6.
  40. 1 2 Holmes G, Kaplan J, Gantz N, Komaroff A, Schonberger L, Straus S, Jones J, Dubois R, Cunningham-Rundles C, Pahwa S (1988). "Chronic fatigue syndrome: a working case definition". Ann Intern Med. 108 (3): 387–89. doi:10.7326/0003-4819-108-3-387. PMID   2829679.
  41. ↑ Fukuda K, Straus S, Hickie I, Sharpe M, Dobbins J, Komaroff A, International Chronic Fatigue Syndrome Study Group (1994). "The chronic fatigue syndrome: a comprehensive approach to its definition and study". Ann. Intern. Med. 121 (12): 953–59. doi:10.7326/0003-4819-121-12-199412150-00009. PMID   7978722. S2CID   510735.
  42. ↑ Palca J (September 14, 1990). "Does a retrovirus explain fatigue syndrome puzzle?". Science. 249 (4974): 1240–12. Bibcode:1990Sci...249.1240P. doi:10.1126/science.2399461. PMID   2399461.
  43. ↑ Altman, Lawrence K. (September 5, 1990). "Virus found that may be linked to a debilitating fatigue ailment". The New York Times. Retrieved February 24, 2009.
  44. ↑ DeFreitas E, Hilliard B, Cheney PR, et al. (April 1991). "Retroviral sequences related to human T-lymphotropic virus type II in patients with chronic fatigue immune dysfunction syndrome". Proc. Natl. Acad. Sci. U.S.A. 88 (7): 2922–26. Bibcode:1991PNAS...88.2922D. doi: 10.1073/pnas.88.7.2922 . PMC   51352 . PMID   1672770.
  45. ↑ Sam Donaldson, Nancy Snyderman, Paul Cheney, David Bell, Elaine DeFreitas, Hillary Johnson, PWC's, Paul Pollard, Mrs. Dailor, Philip Lee (March 27, 1996). Sick & Tired (Television). ABC News.
  46. ↑ Centers for Disease Control Prevention (CDC) (March 1993). "Inability of retroviral tests to identify persons with chronic fatigue syndrome, 1992". Morbidity and Mortality Weekly Report . 42 (10). U.S. Centers for Disease Control and Prevention (CDC): 183, 189–90. PMID   8446093 . Retrieved February 23, 2009.
  47. ↑ Royal Colleges of Physicians, Psychiatrists and General Practitioners (1996). Chronic fatigue syndrome; Report of a joint working group of the Royal Colleges of Physicians, Psychiatrists and General Practitioners. London: Royal College of Physicians of London. ISBN   1-86016-046-8.
  48. ↑ CFS/ME Working Group (2002). "A report of the CFS/ME working group: report to the chief medical officer of an independent working group". London: Department of Health. Archived from the original on March 22, 2011. Retrieved April 2, 2008.
  49. ↑ "Chronic fatigue syndrome basic facts". Centers for Disease Control and Prevention. May 9, 2006. Retrieved February 7, 2008.
  50. ↑ Gerberding (June 7, 2008). "Address at CFS awareness campaign launch" (PDF). Department of Health and Human Services. Centers for Disease Control and Prevention.
  51. ↑ Alberts B (2011). "Editorial Expression of Concern". Science. 333 (6038): 35. Bibcode:2011Sci...333...35A. doi: 10.1126/science.1208542 . PMID   21628391. S2CID   220100781.
  52. ↑ Silverman RH, Das Gupta J, Lombardi VC, Ruscetti FW, Pfost MA, Hagen KS, Peterson DL, Ruscetti SK, Bagni RK, Petrow-Sadowski C, Gold B, Dean M, Mikovits JA (September 2011). "Partial Retraction". Science. 334 (6053): 176. Bibcode:2011Sci...334..176S. doi:10.1126/science.1212182. PMID   21940859. S2CID   220089974.
  53. ↑ Alberts B (2011). "Retraction". Science. 334 (6063): 1636. Bibcode:2011Sci...334.1636A. doi: 10.1126/science.334.6063.1636-a . PMID   22194552.
  54. ↑ Simmons G, Glynn SA, Komaroff AL, Mikovits JA, Tobler LH, Hackett J, Tang N, Switzer WM, Heneine W, Hewlett IK, Zhao J, Lo SC, Alter HJ, Linnen JM, Gao K, Coffin JM, Kearney MF, Ruscetti FW, Pfost MA, Bethel J, Kleinman S, Holmberg JA, Busch MP, Blood XMRV Scientific Research Working Group (SRWG) (2011). "Failure to Confirm XMRV/MLVs in the Blood of Patients with Chronic Fatigue Syndrome: A Multi-Laboratory Study". Science. 334 (6057): 814–17. Bibcode:2011Sci...334..814S. doi:10.1126/science.1213841. PMC   3299483 . PMID   21940862.
  55. ↑ Lo SC, Pripuzova N, Li B, Komaroff AL, Hung GC, Wang R, Alter HJ (2011). "Retraction for Lo et al., Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors". Proceedings of the National Academy of Sciences. 109 (1): 346. Bibcode:2012PNAS..109..346.. doi: 10.1073/pnas.1119641109 . PMC   3252929 . PMID   22203980.
  56. ↑ "Chronic fatigue syndrome researchers face death threats from militants". The Guardian. August 21, 2011. Retrieved February 2, 2014.
  57. ↑ World Health Organization. "The WHO Family of International Classifications". World Health Organization. Archived from the original on October 3, 2004. Retrieved April 18, 2008.
  58. 1 2 3 4 5 Centers for Disease Control and Prevention, National Center for Health Statistics, Office of the Center Director, Data Policy and Standards (March 2001). A Summary of Chronic Fatigue Syndrome and Its Classification in the International Classification of Diseases (PDF). Centers for disease Control. Archived from the original on June 11, 2014. Retrieved April 29, 2008.{{cite book}}: |last= has generic name (help)CS1 maint: bot: original URL status unknown (link) CS1 maint: multiple names: authors list (link)
  59. ↑ International Classification of Diseases. Vol. I. World Health Organization. 1969. pp. 158, (vol 2, pp. 173).
  60. ↑ International Classification of Diseases. Vol. II. World Health Organization. 1975. p. 182. Archived from the original on July 8, 2008. Retrieved April 30, 2008.
  61. ↑ Centers for Disease Control (2006). "International Classification of Diseases 9th Revision Clinical Modification". National Center for Health Statistics. pp. g 516. Retrieved April 29, 2008. Index to Diseases ftp://ftp.cdc.gov/pub/Health_Statistics/NCHS/Publications/ICD9-CM/2006/Dindex07.zip
  62. ↑ Centers for Disease Control (2006). "International Classification of Diseases 9th Revision Clinical Modification". National Center for Health Statistics. pp. g 532. Retrieved April 29, 2008. Tabular List ftp://ftp.cdc.gov/pub/Health_Statistics/NCHS/Publications/ICD9-CM/2006/Dtab07.zip
  63. ↑ International Classification of Diseases (Tabular List ed.). World Health Organization. 2007.
  64. ↑ https://www.cdc.gov/nchs/icd/icd10cm.htm International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM), 2010 Update. Retrieved 2010-05-21.
  65. ↑ Jarman, John (January 25, 2006). "Chronic Fatigue Syndrome Advisory Committee Sixth Meeting". U.S. Department of Health & Human Services. Archived from the original on July 20, 2008. Retrieved April 30, 2008.
  66. ↑ "ICD-10-CM Codes | Diagnosis | Healthcare Providers | Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) | CDC". www.cdc.gov. December 22, 2022. Retrieved January 21, 2023.
  67. ↑ "8E49 Postviral fatigue syndrome". ICD-11 – Mortality and Morbidity Statistics. Archived from the original on August 1, 2018. Retrieved May 20, 2020. Diseases of the nervous system
  68. ↑ ACHESON ED (April 1959). "The clinical syndrome variously called benign myalgic encephalomyelitis, Iceland disease and epidemic neuromyasthenia". The American Journal of Medicine. 26 (4): 569–95. doi:10.1016/0002-9343(59)90280-3. PMID   13637100.
  69. ↑ Shelokov A, Habel K, Verder E, Welsh W (August 1957). "Epidemic neuromyasthenia; an outbreak of poliomyelitislike illness in student nurses". The New England Journal of Medicine. 257 (8): 345–355. doi:10.1056/NEJM195708222570801. PMID   13464938.
  70. ↑ Blattner RJ (October 1956). "Benign myalgic encephalomyelitis (Akureyri disease, Iceland disease)". The Journal of Pediatrics. 49 (4): 504–506. doi:10.1016/S0022-3476(56)80241-2. PMID   13358047.
  71. ↑ Straus SE, ed. (1994). Chronic Fatigue Syndrome. New York, Basel, Hong Kong: Marcel Dekker Inc. p. 227. ISBN   978-0-8247-9187-2.
  72. ↑ Aoki T, Usuda Y, Miyakoshi H, Tamura K, Herberman RB (1987). "Low natural killer syndrome: clinical and immunologic features". Natural Immunity and Cell Growth Regulation. 6 (3): 116–128. PMID   2442602.
  73. ↑ Wessely S (October 1991). "History of postviral fatigue syndrome". British Medical Bulletin. 47 (4): 919–941. doi:10.1093/oxfordjournals.bmb.a072521. PMID   1794091. S2CID   12964461.
  74. ↑ Simpson LO (October 1991). "Myalgic encephalomyelitis". Journal of the Royal Society of Medicine. 84 (10): 633. PMC   1295578 . PMID   1744860.
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