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Huntington's disease (HD), also known as Huntington's chorea, is an incurable neurodegenerative disease that is mostly inherited. The earliest symptoms are often subtle problems with mood or mental/psychiatric abilities. A general lack of coordination and an unsteady gait often follow. It is also a basal ganglia disease causing a hyperkinetic movement disorder known as chorea. As the disease advances, uncoordinated, involuntary body movements of chorea become more apparent. Physical abilities gradually worsen until coordinated movement becomes difficult and the person is unable to talk. Mental abilities generally decline into dementia, depression, apathy, and impulsivity at times. The specific symptoms vary somewhat between people. Symptoms usually begin between 30 and 50 years of age, and can start at any age but are usually seen around the age of 40. The disease may develop earlier in each successive generation. About eight percent of cases start before the age of 20 years, and are known as juvenile HD, which typically present with the slow movement symptoms of Parkinson's disease rather than those of chorea.
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Huntington's disease-like syndromes are a family of inherited neurodegenerative diseases that closely resemble Huntington's disease (HD) in that they typically produce a combination of chorea, cognitive decline or dementia and behavioural or psychiatric problems.
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References
- ↑ Nancy S Wexler and Michael D Rawlins (2005). "Prejudice in a portrayal of Huntington's disease". The Lancet . 366 (9491): 1069–1070. doi:10.1016/S0140-6736(05)67405-3. S2CID 54392395.
- ↑ Seagle, Steven T.; Teddy Kristiansen (2004). It's a Bird... New York: Vertigo. p. 123. ISBN 978-1-4012-0311-5. OCLC 55071368.
- ↑ Williams, Walter Jon (2011) [1986]. "Chapter Four". Hardwired. Walter Jon Williams. ISBN 9780983740841.
- ↑ "Reikäreuna-elokuvafestivaali - festarilehti 2013 by Tuomas Korolainen - Issuu". 21 August 2013.
- ↑ "Home". huntingtonsdance.org.
- ↑ "Connect with Mark Kelley: Fighting Huntington's disease". CBC, Canada. Retrieved November 22, 2011.
- ↑ "Gemini award nomination for the 'Connect with Mark Kelly' episode featuring Carroll". Gemini awards. Retrieved November 22, 2011.
- ↑ Also see BBC press release at .
- ↑ Grady, Denise (10 March 2020). "Haunted by a Gene". The New York Times. Retrieved 11 December 2020.