Ibuprofen/paracetamol

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Ibuprofen/paracetamol
Combination of
Ibuprofen Nonsteroidal anti-inflammatory drug
Paracetamol Analgesic/antipyretic
Clinical data
Trade names Combogesic, Advil Dual Action with Acetaminophen, Ibupane
Other namesAcetaminophen/ibuprofen
AHFS/Drugs.com Micromedex Detailed Consumer Information
License data
Pregnancy
category
Routes of
administration 		By mouth
ATC code
Legal status
Legal status
Identifiers
CAS Number
KEGG

Ibuprofen/paracetamol, sold under the brand name Combogesic among others, is a fixed-dose combination of two medications, ibuprofen, a non-steroidal anti-inflammatory drug (NSAID); and paracetamol (acetaminophen), an analgesic and antipyretic. [6] It is available as a generic medication. [9] [10] [11]

Contents

Medical uses

Ibuprofen/paracetamol is indicated for the short term management of mild to moderate acute pain. [7]

There is evidence that paracetamol combined with ibuprofen provides pain relief better than either medication used alone. [12] [13]

Adverse effects

Society and culture

Brand names

The combination is available as Combiflam, [11] [14] Advil Dual Action with Acetaminophen, [15] [16] [17] Ibupane, [1] Nuromol and Combogesic. [7]

References

  1. 1 2 3 "Ibupane" (PDF). TGA eBS. Archived from the original on 29 October 2020. Retrieved 29 April 2023.
  2. ↑ "Nuromol Dual Action Pain Relief 200mg/500mg tablets - Summary of Product Characteristics (SmPC)". (emc). 15 June 2022. Archived from the original on 25 February 2023. Retrieved 24 February 2023.
  3. ↑ "Nuromol Pain Relief 200mg/500mg Film Coated Tablets - Summary of Product Characteristics (SmPC)". (emc). 15 June 2022. Archived from the original on 25 February 2023. Retrieved 24 February 2023.
  4. ↑ "Nuromol public assessment report". GOV.UK. 16 August 2021. Archived from the original on 25 February 2023. Retrieved 24 February 2023.
  5. ↑ "Nuromol Dual Action Pain Relief 200mg/500mg tablets (ibuprofen/paracetamol): public consultation". GOV.UK. 13 May 2021. Archived from the original on 25 February 2023. Retrieved 24 February 2023.
  6. 1 2 "Advil Dual Action with Acetaminophen- ibuprofen, acetaminophen tablet, film coated". DailyMed. 1 December 2021. Archived from the original on 25 February 2023. Retrieved 25 February 2023.
  7. 1 2 3 "Combogesic- acetaminophen and ibuprofen tablet, film coated". DailyMed. 9 March 2023. Archived from the original on 7 July 2024. Retrieved 6 July 2024.
  8. ↑ "Combogesic IV- acetaminophen and ibuprofen injection injection". DailyMed. 29 April 2024. Archived from the original on 7 July 2024. Retrieved 6 July 2024.
  9. ↑ "Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). 29 June 2023. Archived from the original on 29 June 2023. Retrieved 29 June 2023.
  10. ↑ "First Generic Drug Approvals 2023". U.S. Food and Drug Administration (FDA). 30 May 2023. Archived from the original on 30 June 2023. Retrieved 30 June 2023.
  11. 1 2 "Combiflam". drugs.com. Archived from the original on 5 February 2015. Retrieved 5 February 2015.
  12. ↑ Ong CK, Seymour RA, Lirk P, Merry AF (April 2010). "Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain". Anesthesia and Analgesia. 110 (4): 1170–9. doi:10.1213/ANE.0b013e3181cf9281. PMID   20142348. S2CID   7948680.
  13. ↑ Moore RA, Derry C (January 2013). "Efficacy of OTC analgesics". International Journal of Clinical Practice. Supplement. 67 (178): 21–5. doi: 10.1111/ijcp.12054 . PMID   23163544. S2CID   205184492.
  14. ↑ "Combiflam". Sanofi India. 28 February 2023. Archived from the original on 3 March 2023. Retrieved 2 March 2023.
  15. ↑ "Advil Dual Action: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Archived from the original on 26 September 2020. Retrieved 28 February 2020.
  16. ↑ "Drug Approval Package: Advil Dual Action with Acetaminophen". U.S. Food and Drug Administration (FDA). 31 March 2020. Archived from the original on 3 March 2023. Retrieved 2 March 2023.
  17. ↑ "FDA approves GSK's Advil Dual Action with Acetaminophen for over-the-counter use in the United States" (Press release). GSK Consumer Healthcare. 28 February 2020. Archived from the original on 29 February 2020. Retrieved 28 February 2020– via PR Newswire.
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