Interstate 220 (I-220) is the designation for two Interstate Highways in the United States, both related to Interstate 20:
Interstate 12 (I-12) is an intrastate Interstate Highway located entirely within the US state of Louisiana. It spans a total of 85.59 miles (137.74 km) in an east–west direction from I-10 in Baton Rouge to an interchange with both I-10 and I-59 in Slidell. Along the way, it passes through the city of Hammond, where it intersects I-55 and US Route 51 (US 51). It also serves the cities of Ponchatoula and Denham Springs, as well as the St. Tammany Parish cities of Covington and Mandeville.
Interstate 20 (I‑20) is a major east–west Interstate Highway in the Southern United States. I-20 runs 1,539 miles (2,477 km) beginning at an interchange with I-10 in Reeves County, Texas, and ending at an interchange with I-95 in Florence, South Carolina. Between Texas and South Carolina, I-20 runs through northern Louisiana, Mississippi, Alabama, and Georgia. The major cities that I-20 connects to include Dallas-Fort Worth, Texas; Shreveport, Louisiana; Jackson, Mississippi; Birmingham, Alabama; Atlanta, Georgia; and Columbia, South Carolina.
Interstate 55 (I-55) is a major Interstate Highway in the central United States. As with most primary Interstates that end in a five, it is a major cross-country, north–south route, connecting the Gulf of Mexico to the Great Lakes. The highway travels from LaPlace, Louisiana, at I-10 to Chicago, Illinois, at U.S. Route 41, at McCormick Place. The major cities that I-55 connects to are New Orleans, Louisiana; Jackson, Mississippi; Memphis, Tennessee; St. Louis, Missouri; and Chicago, Illinois.
Interstate 59 (I-59) is an Interstate Highway located in the southeastern United States. It is a north–south route that spans 445.23 miles (716.53 km) from a junction with I-10 and I-12 at Slidell, Louisiana, to a junction with I-24 near Wildwood, Georgia.
The Ark-La-Tex is a socio-economic tri-state region where the Southern U.S. states of Arkansas, Louisiana, and Texas join together. The region contains portions of Northwest Louisiana, Northeast Texas, and South Arkansas as well as the extreme southeastern tip of Oklahoma, in McCurtain County, partly centered upon the Red River, which flows along the Texas–Oklahoma state line into Southwestern Arkansas and Northwest Louisiana.
Interstate 210 may refer to:
Interstate 110 may refer to:
Interstate 220 (I-220) in Mississippi is a loop around Jackson that provides an Interstate connection for I-55 and I-20. The northern terminus for the route is in the suburb of Ridgeland, at exit 104 on I-55. The highway was Mississippi's first auxiliary Interstate, complete by 1981.
Interstate 310 (I-310) is a short spur route of I-10 west of New Orleans, located entirely in St. Charles Parish, Louisiana. It begins at a point on I-10 just west of Louis Armstrong New Orleans International Airport and the city of Kenner. It travels southward as an elevated freeway across the LaBranche Wetlands and intersects U.S. Route 61 (US 61) in St. Rose. The highway crosses the Mississippi River from Destrehan to Luling via the Hale Boggs Memorial Bridge. After a brief concurrency with Louisiana Highway 3127 (LA 3127), I-310 terminates at US 90 in Boutte.

The Arkansas, Louisiana and Mississippi Railroad is a 52.9-mile (85.1 km) short-line railroad in northern Louisiana and southern Arkansas. Opened in 1908, it has undergone several corporate reorganizations, but has remained independent of larger carriers. In 2004, paper producer Georgia-Pacific sold the company to shortline operator Genesee & Wyoming Inc. Traffic generally consists of lumber, paper, forest products, and chemicals.
Interstate 10 (I-10), a major transcontinental Interstate Highway in the Southern United States, runs across the southern part of Louisiana for 274.42 miles (441.64 km) from Texas to Mississippi. It passes through Lake Charles, Lafayette, and Baton Rouge, dips south of Lake Pontchartrain to serve the New Orleans metropolitan area, then crosses Lake Pontchartrain and leaves the state.
Jackson, MS Metropolitan Statistical Area is a metropolitan statistical area (MSA) in the central region of the U.S. state of Mississippi that covers seven counties: Copiah, Hinds, Holmes, Madison, Rankin, Simpson, and Yazoo. As of the 2010 census, the Jackson MSA had a population of 586,320. According to 2019 estimates, the population has slightly increased to 594,806. Jackson is the principal city of the MSA.
Interstate 55 (I-55) is a major north–south Interstate Highway that serves the middle of the United States. It runs 963.5 miles (1,550.6 km) from I-10 in Laplace, Louisiana—about 25 miles (40 km) west of New Orleans—to U.S. Highway 41 (US 41) in Chicago, Illinois. In Mississippi, it runs for about 290.41 miles (467.37 km), entering the state at the Louisiana state line near Osyka and leaving at the Tennessee state line near Southaven, just south of Memphis.
Interstate 20 (I-20) is a major thoroughfare through the central region of the US state of Mississippi. Spanning 154.5 miles (248.6 km), it connects Jackson and I-55 with Vicksburg and the Mississippi River in the west and Meridian and I-59 in the east.
Interstate 20 (I-20) is a part of the Interstate Highway System that spans 1,539.38 miles (2,477.39 km) from Reeves County, Texas, to Florence, South Carolina. Within the state of Louisiana, the highway travels 189.84 miles (305.52 km) from the Texas state line west of Greenwood to the Mississippi River, which it crosses into Vicksburg, Mississippi.
Interstate 49 (I-49) is an Interstate Highway that currently spans 244.021 miles (392.714 km) in a north–south direction in the US state of Louisiana. Currently, I-49 runs from I-10 in Lafayette to the Arkansas state line. I-49 greatly parallels the older US Highway 71 (US 71) corridor, and connects the state's two east–west Interstates at two of its metropolitan centers. Along the way, it serves the cities of Opelousas, Alexandria, and Natchitoches, intersecting several cross-state highways, such as I-20, US 190, US 167, US 165, and US 84.
Interstate 310 is the designation for several highways in the United States, which are related to Interstate 10: