Interstate 80 (I-80) is an east–west transcontinental freeway that crosses the United States from downtown San Francisco, California, to Teaneck, New Jersey, in the New York metropolitan area. The highway was designated in 1956 as one of the original routes of the Interstate Highway System; its final segment was opened in 1986. The second-longest Interstate Highway in the United States after I-90, it runs through many major cities, including Oakland, Sacramento, Reno, Salt Lake City, Omaha, Des Moines, and Toledo and passes within 10 miles (16 km) of Chicago, Cleveland, and New York City.
Interstate 35 (I-35) is a major Interstate Highway in the central United States. As with most primary Interstates that end in a five, it is a major cross-country, north–south route. It stretches from Laredo, Texas, near the Mexican border to Duluth, Minnesota, at Minnesota State Highway 61 and 26th Avenue East. The highway splits into I-35E and I-35W in two separate places, the Dallas–Fort Worth metroplex in Texas and at the Minnesota twin cities of Minneapolis–Saint Paul.
Interstate 94 (I-94) is an east–west Interstate Highway connecting the Great Lakes and northern Great Plains regions of the United States. Its western terminus is just east of Billings, Montana, at a junction with I-90; its eastern terminus is in Port Huron, Michigan, where it meets with I-69 and crosses the Blue Water Bridge into Sarnia, Ontario, Canada, where the route becomes Ontario Highway 402. It thus lies along the primary overland route from Seattle to Toronto and is the only east–west Interstate Highway to have a direct connection to Canada.
Interstate 65 (I-65) is a major north–south Interstate Highway in the central United States. As with most primary Interstates ending in 5, it is a major crosscountry, north–south route, connecting between the Great Lakes and the Gulf of Mexico. Its southern terminus is located at an interchange with I-10 in Mobile, Alabama, and its northern terminus is at an interchange with US 12 (US 12), and US 20 in Gary, Indiana, just southeast of Chicago. I-65 connects several major metropolitan areas in the Midwest and Southern US. It connects the four largest cities in Alabama: Mobile, Montgomery, Birmingham, and Huntsville. It also serves as one of the main north–south routes through Nashville, Tennessee; Louisville, Kentucky; and Indianapolis, Indiana, each a major metropolitan area in its respective state.
U.S. Route 12 or U.S. Highway 12 (US 12) is an east–west United States Numbered Highway, running from Aberdeen, Washington, to Detroit, Michigan, for almost 2,500 miles (4,000 km). The highway has mostly been superseded by Interstate 90 (I-90) and I-94, but, unlike most U.S. Highways that have been superseded by an Interstate, US 12 remains intact as an important link for local and regional destinations. The highway's western terminus in Aberdeen is at an intersection with US 101, while the highway's eastern terminus in Downtown Detroit is at the corner of Michigan and Cass avenues, near Campus Martius Park.
U.S. Route 27 or U.S. Highway 27 (US 27) is a north–south United States Numbered Highway in the Southern and Midwestern U.S. The southern terminus is at US 1 in Miami, Florida. The northern terminus is at Interstate 69 (I-69) in Fort Wayne, Indiana. From Miami, it goes up the center of Florida, then west to Tallahassee, Florida, and north through such cities and towns as Columbus, Georgia; Rome, Georgia; Chattanooga, Tennessee; Lexington, Kentucky; Cincinnati, Ohio; Oxford, Ohio; Richmond, Indiana; and Fort Wayne, Indiana. It once extended north through Lansing, Michigan, to Cheboygan, Mackinaw City, and, for about three years, even as far as St. Ignace. US 27 was first signed in 1926, replacing what had been the eastern route of the Dixie Highway in many states.
U.S. Route 30 or U.S. Highway 30 (US 30) is an east–west main route of the United States Numbered Highway System, with the highway traveling across the Northern U.S. With a length of 3,072 miles (4,944 km), it is the third-longest U.S. Highway, after US 20 and US 6. The western end of the highway is at US 101 in Astoria, Oregon; the eastern end is at Virginia Avenue, Absecon Boulevard, and Adriatic Avenue in Atlantic City, New Jersey. The "0" as the last digit in the number indicates that it is a coast-to-coast route and a major east–west route. Despite long stretches of parallel and concurrent Interstate Highways, it has not been decommissioned unlike other long-haul routes such as US 66. It is also the only U.S. Highway that has always been coast-to-coast since the beginning of U.S. Numbered Highway System.
U.S. Route 93 (US 93) is a major north–south 1,359-mile (2,187 km) U.S. Numbered Highway in the western United States, that connects U.S. Route 60 (US 60) in Wickenburg, Arizona with British Columbia Highway 93 at the Canadian border. The highway passes through Kingman, Arizona; Las Vegas, Nevada; Twin Falls, Idaho; and Missoula, Montana.
U.S. Route 20 or U.S. Highway 20 (US 20) is an east–west United States Numbered Highway that stretches from the Pacific Northwest east to New England. The "0" in its route number indicates that US 20 is a major coast-to-coast route. Spanning 3,365 miles (5,415 km), it is the longest road in the United States, and, in the east, the route is roughly parallel to Interstate 90 (I-90), which is the longest Interstate Highway in the U.S. There is a discontinuity in the official designation of US 20 through Yellowstone National Park, with unnumbered roads used to traverse the park.
U.S. Route 40 or U.S. Highway 40 (US 40), also known as the Main Street of America, is a major east–west United States Highway traveling across the United States from the Mountain States to the Mid-Atlantic States. As with most routes whose numbers end in a zero, US 40 once traversed the entire United States. It is one of the first U.S. Highways created in 1926 and its original termini were in San Francisco, California, and Atlantic City, New Jersey. US 40 currently ends at a junction with I-80 in Silver Summit, Utah, just outside Salt Lake City. West of this point US 40 was functionally replaced with I-80, and as these segments of I-80 were constructed the western portion of US 40 was truncated several times.
U.S. Route 50 or U.S. Highway 50 (US 50) is a major east–west route of the U.S. Highway system, stretching 3,019 miles (4,859 km) from Interstate 80 (I-80) in West Sacramento, California, to Maryland Route 528 in Ocean City, Maryland, on the Atlantic Ocean. Until 1972, when it was replaced by Interstate Highways west of the Sacramento area, it extended to San Francisco, near the Pacific Ocean. The Interstates were constructed later and are mostly separate from this route. It generally serves a corridor south of I-70 and I-80 and north of I-64 and I-40.
U.S. Route 41, also U.S. Highway 41 (US 41), is a major north–south United States Numbered Highway that runs from Miami, Florida, to the Upper Peninsula of Michigan. Until 1949, the part in southern Florida, from Naples to Miami, was US 94. The highway's southern terminus is in the Brickell neighborhood of Downtown Miami at an intersection with Brickell Avenue (US 1), and its northern terminus is east of Copper Harbor, Michigan, at a modest cul-de-sac near Fort Wilkins Historic State Park at the tip of the Keweenaw Peninsula. US 41 closely parallels Interstate 75 (I-75) from Naples, Florida, all the way through Georgia to Chattanooga, Tennessee.
U.S. Route 6 (US 6) or U.S. Highway 6 (US 6), also called the Grand Army of the Republic Highway, honoring the American Civil War veterans association, is a main route of the United States Numbered Highway System. While it currently runs east-northeast from Bishop, California, to Provincetown, Massachusetts, the route has been modified several times. The highway's longest-lasting routing, from 1936 to 1964, had its western terminus at Long Beach, California. During this time, US 6 was the longest highway in the country.
U.S. Route 31 or U.S. Highway 31 (US 31) is a major north–south U.S. highway connecting southern Alabama to northern Michigan. Its southern terminus is at an intersection with US 90/US 98 in Spanish Fort, Alabama. Its northern terminus is at an interchange with Interstate 75 (I-75) south of Mackinaw City, Michigan.
U.S. Route 33 (US 33) is a United States Numbered Highway that runs northwest–southeast for 709 miles (1,141 km) from northern Indiana to Richmond, Virginia, passing through Ohio and West Virginia en route. Although most odd-numbered U.S. routes are north–south, US 33 is labeled east–west throughout its route, except in Indiana where it is labeled north–south. It roughly follows a historic trail used by Native Americans from Chesapeake Bay to Lake Michigan.
State Road 51 in the U.S. state of Indiana is a north–south route on the state highway system in northwest Indiana. It consists of a route 9.56 miles (15.39 km) long from a point on U.S. Route 30 4 miles (6.4 km) east of Merrillville and 8 miles (13 km) west of Valparaiso, north to U.S. Route 20 in Gary. Immediately north of US 30, the highway is signed as the Adam Benjamin Highway.
Interstate 80 (I-80) is a part of the Interstate Highway System that runs from San Francisco, California, to Teaneck, New Jersey. I-80 enters Illinois from Iowa in the west, southwest of Rapids City, and runs generally eastward through East Moline, LaSalle, and Joliet, before entering Indiana in Lansing. The Interstate runs for approximately 163.52 miles (263.16 km) through the state.
Interstate 94 (I-94) is a part of the Interstate Highway System that runs from Billings, Montana, to Port Huron, Michigan. I-94 enters Indiana from Illinois in the west, in Munster, and runs generally eastward through Hammond, Gary, and Portage, before entering Michigan northeast of Michigan City. The Interstate runs for approximately 45.8 miles (73.7 km) through the state. The landscape traversed by I-94 includes urban areas of Northwest Indiana, wooded areas, and farmland. The section of I-94 between the Illinois state line and Lake Station is named the Frank Borman Expressway.
U.S. Route 41 (US 41) in the state of Indiana is a north–south US Highway that is parallel to the Illinois state line. It enters the state south of Evansville as a four-lane divided highway passing around Vincennes and traveling north to Terre Haute. In Terre Haute, it is known as 3rd Street. North of Terre Haute, it hooks east and becomes a two-lane surface road. Those wanting to stay on a four-lane divided highway can use State Road 63 to the west. It passes through Rockville, Veedersburg, and Attica before returning to a four-lane divided highway when SR 63 terminates in Warren County. It remains a four-lane divided highway until Lake County, where it becomes a main road known as Indianapolis Boulevard. It overlaps US 12 and US 20 in Hammond and exits Indiana into the South Side of Chicago.
The Great Lakes Circle Tour is a designated scenic road system connecting all of the Great Lakes and the St. Lawrence River. It consists of routes for circumnavigating the lakes, either individually or collectively. It was designated by the Great Lakes Commission in 1988.
SR 75 
I-90 Toll 