Interstate 80 (I-80) is an east–west transcontinental freeway that crosses the United States from San Francisco, California, to Teaneck, New Jersey, in the New York metropolitan area. The highway was designated in 1956 as one of the original routes of the Interstate Highway System; its final segment was opened in 1986. The second-longest Interstate Highway in the United States after I-90, it runs through many major cities, including Oakland, Sacramento, Reno, Salt Lake City, Omaha, Des Moines, and Toledo and passes within 10 miles (16 km) of Chicago, Cleveland, and New York City.
Interstate 39 (I-39) is a highway in the Midwestern United States. I-39 runs from Normal, Illinois, at I-55 to State Trunk Highway 29 (WIS 29) in the town of Rib Mountain, Wisconsin, which is approximately six miles (9.7 km) south of Wausau. I-39 was designed to replace U.S. Route 51 (US 51), which, in the early 1980s, was one of the busiest two-lane highways in the United States. I-39 was built in the 1980s and 1990s.
Interstate 94 (I-94) is an east–west Interstate Highway connecting the Great Lakes and northern Great Plains regions of the United States. Its western terminus is just east of Billings, Montana, at a junction with I-90; its eastern terminus is in Port Huron, Michigan, where it meets with I-69 and crosses the Blue Water Bridge into Sarnia, Ontario, Canada, where the route becomes Ontario Highway 402. It thus lies along the primary overland route from Seattle to Toronto and is the only east–west Interstate Highway to have a direct connection to Canada.
U.S. Route 12 or U.S. Highway 12 (US 12) is an east–west United States Numbered Highway, running from Aberdeen, Washington, to Detroit, Michigan, for almost 2,500 miles (4,000 km). The highway has mostly been superseded by Interstate 90 (I-90) and I-94, but, unlike most U.S. Highways that have been superseded by an Interstate, US 12 remains intact as an important link for local and regional destinations. The highway's western terminus in Aberdeen is at an intersection with US 101, while the highway's eastern terminus in Downtown Detroit is at the corner of Michigan and Cass avenues, near Campus Martius Park.
U.S. Route 81 or U.S. Highway 81 (US 81) is a major north–south U.S. highway that extends for 1,220 miles (1,960 km) in the central United States and is one of the original United States Numbered Highways established in 1926 by the American Association of State Highway Officials.
U.S. Route 20 or U.S. Highway 20 (US 20) is an east–west United States Numbered Highway that stretches from the Pacific Northwest east to New England. The "0" in its route number indicates that US 20 is a major coast-to-coast route. Spanning 3,365 miles (5,415 km), it is the longest road in the United States, and, in the east, the route is roughly parallel to Interstate 90 (I-90), which is the longest Interstate Highway in the U.S. There is a discontinuity in the official designation of US 20 through Yellowstone National Park, with unnumbered roads used to traverse the park.
U.S. Route 45 is a major north-south United States highway and a border-to-border route, from Lake Superior to the Gulf of Mexico. A sign at the highway's northern terminus notes the total distance as 1,297 miles (2,087 km).
U.S. Route 50 or U.S. Highway 50 (US 50) is a major east–west route of the U.S. Highway system, stretching 3,019 miles (4,859 km) from Interstate 80 (I-80) in West Sacramento, California, to Maryland Route 528 in Ocean City, Maryland, on the Atlantic Ocean. Until 1972, when it was replaced by Interstate Highways west of the Sacramento area, it extended to San Francisco, near the Pacific Ocean. The Interstates were constructed later and are mostly separate from this route. It generally serves a corridor south of I-70 and I-80 and north of I-64 and I-40.
U.S. Route 79 is a United States highway in the Southern United States. The route is officially considered and labeled as a north–south highway, but its path is actually more of a diagonal northeast–southwest highway. The highway's northern/eastern terminus is in Crawfordsville, Kentucky, where it turns into Bing's Store Road just north of IH-40. Its southern/western terminus is in Round Rock, Texas, at an interchange with Interstate 35, ten miles (16 km) north of Austin. US 79, US 68, and Interstate 24/US 62 are the primary east–west access points for the Land Between the Lakes recreation area straddling the Kentucky/Tennessee border.
U.S. Route 41, also U.S. Highway 41 (US 41), is a major north–south United States Numbered Highway that runs from Miami, Florida, to the Upper Peninsula of Michigan. Until 1949, the part in southern Florida, from Naples to Miami, was US 94. The highway's southern terminus is in the Brickell neighborhood of Downtown Miami at an intersection with Brickell Avenue (US 1), and its northern terminus is east of Copper Harbor, Michigan, at a modest cul-de-sac near Fort Wilkins Historic State Park at the tip of the Keweenaw Peninsula. US 41 is closely paralleled by Interstate 75 (I-75) from Naples, Florida, all the way through Georgia to Chattanooga, Tennessee.
U.S. Route 52 (US 52) is a major United States highway in the central United States that extends from the northern to southeastern region of the United States. Contrary to most other even-numbered U.S. Highways, US 52 primarily follows a northwest–southeast route, and is signed north–south or east–west depending on the local orientation of the route. The highway's northwestern terminus is in Portal, North Dakota at the Canada–United States border, where it continues as Saskatchewan Highway 39. Its southeastern terminus is in Charleston, South Carolina, at Number 2 Meeting Street and White Point Garden along the Charleston Harbor.
U.S. Route 59 is a north–south United States highway. A latecomer to the U.S. numbered route system, US 59 is now a border-to-border route, part of the NAFTA Corridor Highway System. It parallels U.S. Route 75 for nearly its entire route, never much more than 100 miles (160 km) away, until it veers southwest in Houston, Texas. Its number is out of place since US 59 is either concurrent with or entirely west of U.S. Route 71. The highway's northern terminus is 9 mi (14 km) north of Lancaster, Minnesota, at the Lancaster–Tolstoi Border Crossing on the Canada–US border, where it continues as Manitoba Highway 59. Its southern terminus is at the Mexico–US border in Laredo, Texas, where it continues as Mexican Federal Highway 85D.
U.S. Route 31 or U.S. Highway 31 (US 31) is a major north–south U.S. highway connecting southern Alabama to northern Michigan. Its southern terminus is at an intersection with US 90/US 98 in Spanish Fort, Alabama. Its northern terminus is at an interchange with Interstate 75 (I-75) south of Mackinaw City, Michigan.
U.S. Route 51 or U.S. Highway 51 is a major south–north United States highway that extends 1,277 miles (2,055 km) from the western suburbs of New Orleans, Louisiana, to within 150 feet (46 m) of the Wisconsin–Michigan state line. As most of the United States Numbered Highways ending with "1", it is a cross-country north–south route extending from the Gulf Coast region to the Great Lakes region. Much of the highway in northern Illinois and southern Wisconsin runs parallel to or is cosigned with Interstate 39 (I-39) and much of the route in several states also parallels the Illinois Central Railroad. From LaPlace, Louisiana, Mississippi, to Memphis, Tennessee, much of that portion of US 51 runs largely parallel or is concurrent with Interstate 55 (I-55). The highway's northern terminus is between Hurley, Wisconsin, and Ironwood, Michigan, where it ends with a roundabout at US 2. Its southern terminus is in Laplace, Louisiana, ending at US 61. US 51 is routed through the states of Louisiana, Mississippi, Tennessee, Kentucky, Illinois, and Wisconsin.
U.S. Route 221 (US 221) is a 734-mile-long (1,181 km) spur of U.S. Route 21. It travels from Perry, Florida, at US 19/US 98/US 27 Alternate to Lynchburg, Virginia, at US 29 Business. It travels through the states of Florida, Georgia, South Carolina, North Carolina, and Virginia. It travels through the cities of Valdosta, Georgia; Spartanburg, South Carolina; Marion, North Carolina; Roanoke, Virginia; and Lynchburg, Virginia.
State Road 51 in the U.S. state of Indiana is a north–south route on the state highway system in northwest Indiana. It consists of a route 9.56 miles (15.39 km) long from a point on U.S. Route 30 4 miles (6.4 km) east of Merrillville and 8 miles (13 km) west of Valparaiso, north to U.S. Route 20 in Gary. Immediately north of US 30, the highway is signed as the Adam Benjamin Highway.
State Route 4 is a 168.85-mile (271.74 km) long state highway located in southern and western Maine. It is a major interregional route and the first such route to be designated in the state. The southern terminus is at the New Hampshire border in South Berwick, where it connects to New Hampshire Route 4, and the northern terminus is at Haines Landing on Mooselookmeguntic Lake in Rangeley. Major cities and towns along the length of SR 4 include Sanford, Gorham, Windham, Auburn and Farmington.
Interstate 94 (I-94) runs east–west through the western, central, and southeastern portions of the US state of Wisconsin. A total of 348.23 miles (560.42 km) of I-94 lie in the state.
Interstate 94 (I-94) is a part of the Interstate Highway System that runs from Billings, Montana, to Port Huron, Michigan. I-94 enters Indiana from Illinois in the west, in Munster, and runs generally eastward through Hammond, Gary, and Portage, before entering Michigan northeast of Michigan City. The Interstate runs for approximately 45.8 miles (73.7 km) through the state. The landscape traversed by I-94 includes urban areas of Northwest Indiana, wooded areas, and farmland. The section of I-94 between the Illinois state line and Lake Station is named the Frank Borman Expressway.
U.S. Highway 11 (US 11) is a part of the United States Numbered Highway System that spans 1,645 miles (2,647 km) from New Orleans, Louisiana, to Rouses Point, New York. Within the state of Louisiana, the highway travels 31 miles (50 km) from the national southern terminus at US 90 in New Orleans to the Mississippi state line south of Picayune.
I-80 / I-94 / US 6 at Illinois state line
I-65 in Gary 
US 421 near Michigan City 
US 31 in South Bend 
SR 13 near Middlebury 
I-69 near Angola 
I-80 Toll / I-90 Toll / Ohio Turnpike at Ohio state line
