| Combination of | |
|---|---|
| Isoniazid | Anti-tuberculosis medication |
| Pyridoxine | Vitamin |
| Sulfamethoxazole | Antibiotic |
| Trimethoprim | Antibiotic |
| Clinical data | |
| Routes of administration | By mouth [1] |
| ATC code | |
Isoniazid/pyridoxine/sulfamethoxazole/trimethoprim (INH/B6/CTX) is a fixed-dose combination medication for the prevention of opportunistic infections in HIV/AIDS. [1] It combines isoniazid, pyridoxine, sulfamethoxazole, and trimethoprim. [1] Specifically it is used to prevent tuberculosis, toxoplasmosis, pneumonia, malaria, and isosporiasis. [2] It is taken by mouth. [1]
Side effects may include trouble concentrating, numbness, vomiting, and rash. [2] Serious side effects may include liver problems. [2] Caution may be required in people with G6PD deficiency. [2] While it has not been well studied, use in pregnancy appears to be okay. [2]
It is on the World Health Organization's List of Essential Medicines. [1] While benefits include being able to take less pills, it is unclear if this version changes peoples adherence to treatment. [2] Other studies, however, have found fixed-dose combinations to be useful for this purpose. [2]
