Lisinopril/hydrochlorothiazide

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Lisinopril/hydrochlorothiazide
Lisinoprilhctz.png
Lisinopril (top) and hydrochlorothiazide (bottom)
Combination of
Lisinopril ACE inhibitor
Hydrochlorothiazide Thiazide diuretic
Clinical data
Trade names Zestoretic, Prinzide, others
Other nameslisinopril/hctz
AHFS/Drugs.com Micromedex Detailed Consumer Information
MedlinePlus a601070
License data
Pregnancy
category
  • Contraindicated
Routes of
administration 		By mouth
ATC code
Legal status
Legal status
Identifiers
CAS Number
KEGG
   (verify)

Lisinopril/hydrochlorothiazide, sold under the brand name Zestoretic among others, is a fixed-dose combination medication used for the treatment of high blood pressure (hypertension). [2] It contains lisinopril, an ACE inhibitor, and hydrochlorothiazide, a diuretic. [2] [3] Typically, it becomes an option once a person is doing well on the individual components. [4] It is taken by mouth. [3]

Contents

Common side effects include dizziness, headache, cough, and feeling tired. [2] Severe side effects may include angioedema and low blood pressure. [2] Use during pregnancy may harm the baby. [2]

The combination was approved for medical use in the United States in 1989. [3] It is on the World Health Organization's List of Essential Medicines. [5] It is available as a generic medication. [4] In 2023, the combination was the 58th most commonly prescribed medication in the United States, with more than 10 million prescriptions. [6] [7]

Medical uses

Lisinopril/hydrochlorothiazide is indicated for the treatment of hypertension, to lower blood pressure. [2]

Adverse effects

The US Food and Drug Administration prescription label for the combination contains a boxed warning about harm to the baby. [2]

References

  1. ↑ "Product monograph brand safety updates". Health Canada. February 2024. Retrieved 24 March 2024.
  2. 1 2 3 4 5 6 7 8 "Zestoretic- lisinopril and hydrochlorothiazide tablet". DailyMed. Retrieved 9 February 2022.
  3. 1 2 3 "Hydrochlorothiazide and lisinopril Uses, Side Effects & Warnings". Drugs.com. Cerner Multum. Retrieved 26 December 2018.
  4. 1 2 British national formulary : BNF 74 (74 ed.). British Medical Association. 2017. p. 166. ISBN   978-0857112989.
  5. ↑ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl: 10665/371090 . WHO/MHP/HPS/EML/2023.02.
  6. ↑ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
  7. ↑ "Hydrochlorothiazide; Lisinopril Drug Usage Statistics, United States, 2013 - 2023". ClinCalc. Retrieved 18 August 2025.


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