Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase

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Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase
Identifiers
EC no. 3.6.1.53
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Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase (EC 3.6.1.53, Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase, ADPRibase-Mn) is an enzyme with systematic name CDP-choline phosphohydrolase. [1] [2] This enzyme catalyses the following chemical reaction

(1) CDP-choline + H2O CMP + phosphocholine
(2) ADP-ribose + H2O AMP + D-ribose 5-phosphate

This enzyme requires Mn2+, which cannot be replaced by Mg2+.

Related Research Articles

<span class="mw-page-title-main">Cyclic ADP-ribose</span> Chemical compound

Cyclic ADP Ribose, frequently abbreviated as cADPR, is a cyclic adenine nucleotide (like cAMP) with two phosphate groups present on 5' OH of the adenosine (like ADP), further connected to another ribose at the 5' position, which, in turn, closes the cycle by glycosidic bonding to the nitrogen 1 (N1) of the same adenine base (whose position N9 has the glycosidic bond to the other ribose). The N1-glycosidic bond to adenine is what distinguishes cADPR from ADP-ribose (ADPR), the non-cyclic analog. cADPR is produced from nicotinamide adenine dinucleotide (NAD+) by ADP-ribosyl cyclases (EC 3.2.2.5) as part of a second messenger system.

The enzyme FAD-AMP lyase (cyclizing) catalyzes the reaction

<span class="mw-page-title-main">ADP-ribose diphosphatase</span>

ADP-ribose diphosphatase (EC 3.6.1.13) is an enzyme that catalyzes a hydrolysis reaction in which water nucleophilically attacks ADP-ribose to produce AMP and D-ribose 5-phosphate. Enzyme hydrolysis occurs by the breakage of a phosphoanhydride bond and is dependent on Mg2+ ions that are held in complex by the enzyme.

In enzymology, an ADP-sugar diphosphatase (EC 3.6.1.21) is an enzyme that catalyzes the chemical reaction

In enzymology, a CDP-diacylglycerol diphosphatase (EC 3.6.1.26) is an enzyme that catalyzes the chemical reaction

In enzymology, a CDP-glycerol diphosphatase (EC 3.6.1.16) is an enzyme that catalyzes the chemical reaction

In enzymology, a manganese-transporting ATPase (EC 3.6.3.35) is an enzyme that catalyzes the chemical reaction

In enzymology, a NAD+ diphosphatase (EC 3.6.1.22) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Nucleoside-diphosphatase</span> Group of proteins having nucleoside-diphosphatase activity

In enzymology, a nucleoside-diphosphatase (EC 3.6.1.6) is an enzyme that catalyzes the chemical reaction

In enzymology, a nucleotide diphosphatase (EC 3.6.1.9) is an enzyme that catalyzes the chemical reaction

In enzymology, an UDP-sugar diphosphatase (EC 3.6.1.45) is an enzyme that catalyzes the chemical reaction

In enzymology, an undecaprenyl-diphosphatase (EC 3.6.1.27) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">ADP-ribosyl cyclase</span>

In enzymology, a ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase (EC 3.2.2.6) is a bifunctional enzyme that catalyzes the chemical reaction

In enzymology, a 2'-phosphotransferase (EC 2.7.1.160) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">NUDT9</span> Protein-coding gene in the species Homo sapiens

ADP-ribose pyrophosphatase, mitochondrial is an enzyme that in humans is encoded by the NUDT9 gene.

ADP-ribose 1′′-phosphate phosphatase (EC 3.1.3.84, POA1, Appr1p phosphatase, Poa1p) is an enzyme with systematic name ADP-D-ribose 1′′-phosphate phosphohydrolase. This enzyme catalyses the following chemical reaction

Geranyl diphosphate diphosphatase (EC 3.1.7.11, geraniol synthase', geranyl pyrophosphate pyrophosphatase) is an enzyme with systematic name geranyl-diphosphate diphosphohydrolase. This enzyme catalyses the following chemical reaction

UDP-2,3-diacylglucosamine diphosphatase (EC 3.6.1.54, UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine pyrophosphatase, ybbF (gene), lpxH (gene)) is an enzyme with systematic name UDP-2,3-bis((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine 2,3-bis((3R)-3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate phosphohydrolase. This enzyme catalyses the following chemical reaction

M7GpppX diphosphatase (EC 3.6.1.59, DcpS, m7GpppX pyrophosphatase, m7GpppN m7GMP phosphohydrolase) is an enzyme with systematic name m7G5'ppp5'N m7GMP phosphohydrolase. This enzyme catalyses the following chemical reaction

Alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase (EC 3.6.1.63, phnM (gene)) is an enzyme with systematic name alpha-D-ribose-1-methylphosphonate-5-triphosphate diphosphohydrolase. This enzyme catalyses the following chemical reaction

References

  1. ↑ Canales J, Pinto RM, Costas MJ, Hernández MT, Miró A, Bernet D, Fernández A, Cameselle JC (January 1995). "Rat liver nucleoside diphosphosugar or diphosphoalcohol pyrophosphatases different from nucleotide pyrophosphatase or phosphodiesterase I: substrate specificities of Mg(2+)-and/or Mn(2+)-dependent hydrolases acting on ADP-ribose". Biochimica et Biophysica Acta. 1246 (2): 167–77. doi:10.1016/0167-4838(94)00191-i. PMID   7819284.
  2. ↑ Canales J, Fernández A, Ribeiro JM, Cabezas A, Rodrigues JR, Cameselle JC, Costas MJ (July 2008). "Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells" (PDF). The Biochemical Journal. 413 (1): 103–13. doi:10.1042/bj20071471. PMID   18352857. S2CID   26036152.
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