Netarsudil/latanoprost

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Netarsudil/latanoprost
Combination of
Netarsudil Rho kinase inhibitor
Latanoprost Prostaglandin F2α analogue
Clinical data
Trade names Rocklatan, Roclanda
AHFS/Drugs.com Professional Drug Facts
License data
Routes of
administration
Eye drops
ATC code
Legal status
Legal status
Identifiers
KEGG

Netarsudil/latanoprost, sold under the brand name Rocklatan among others, is a fixed-dose combination medication use to treat elevated intraocular pressure (IOP) in people with open-angle glaucoma or ocular hypertension. [1] [2] It contains netarsudil mesylate and latanoprost. [1] [2] It is applied as eye drops to the eyes. [1] [2]

The most common side effects include conjunctival hyperaemia (red eye), pain at the site where the medicine was applied, cornea verticillata (deposits in the cornea, the transparent layer in front of the eye that covers the pupil and iris), pruritus (itching of the eye), erythema (reddening) and discomfort in the eye, increased lacrimation (watery eyes), and conjunctival haemorrhage (bleeding in the surface layer of the eye). [2]

Netarsudil/latanoprost was approved for medical use in the United States in March 2019, [4] and in the European Union in January 2021. [2]

Medical uses

Netarsudil/latanoprost is indicated for the reduction of elevated intraocular pressure (IOP) in adults with primary open-angle glaucoma or ocular hypertension. [1] [2]

Related Research Articles

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Glaucoma is a group of eye diseases that lead to damage of the optic nerve, which transmits visual information from the eye to the brain. Glaucoma may cause vision loss if left untreated. It has been called the "silent thief of sight" because the loss of vision usually occurs slowly over a long period of time. A major risk factor for glaucoma is increased pressure within the eye, known as intraocular pressure (IOP). It is associated with old age, a family history of glaucoma, and certain medical conditions or medications. The word glaucoma comes from the Ancient Greek word γλαυκός, meaning 'gleaming, blue-green, gray'.

<span class="mw-page-title-main">Intraocular pressure</span> Fluid pressure inside the eye

Intraocular pressure (IOP) is the fluid pressure inside the eye. Tonometry is the method eye care professionals use to determine this. IOP is an important aspect in the evaluation of patients at risk of glaucoma. Most tonometers are calibrated to measure pressure in millimeters of mercury (mmHg).

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<span class="mw-page-title-main">Latanoprost</span> Chemical compound

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<span class="mw-page-title-main">Timolol</span> Chemical compound

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<span class="mw-page-title-main">Brinzolamide</span> Chemical compound

Brinzolamide is a carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension.

<span class="mw-page-title-main">Bimatoprost</span> Chemical compound

Bimatoprost, sold under the brand name Lumigan among others, is a medication used to treat high pressure inside the eye including glaucoma. Specifically it is used for open angle glaucoma when other agents are not sufficient. It may also be used to increase the size of the eyelashes. It is used as an eye drop and effects generally occur within four hours.

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<span class="mw-page-title-main">Levobetaxolol</span> Chemical compound

Levobetaxolol is a drug used to lower the pressure in the eye in treating conditions such as glaucoma. It is marketed as a 0.25 or 0.5% ophthalmic solution of levobetaxolol hydrochloride under the trade name Betaxon. Levobetaxolol is a beta-adrenergic receptor inhibitor.

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<span class="mw-page-title-main">Netarsudil</span> Chemical compound

Netarsudil, sold under the brand name Rhopressa among others, is a medication for the treatment of glaucoma. In the United States, in December 2017, the Food and Drug Administration (FDA) approved a 0.02% ophthalmic solution for the lowering of elevated intraocular pressure in people with open-angle glaucoma or ocular hypertension. The European Medicines Agency approved it in 2019 for the same uses under the brand name Rhokiinsa.

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Latanoprostene bunod, sold under the brand name Vyzulta, is an ophthalmic medication used for the reduction of intraocular pressure in people with open-angle glaucoma or ocular hypertension. It targets the trabecular meshwork directly. It is a prostaglandin analog.

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<span class="mw-page-title-main">Omidenepag</span> Medication

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References

  1. 1 2 3 4 5 "Rocklatan- netarsudil and latanoprost ophthalmic solution, 0.02%/0.005% solution/ drops". DailyMed. 10 March 2020. Retrieved 2 June 2020.
  2. 1 2 3 4 5 6 7 "Roclanda EPAR". European Medicines Agency (EMA). 9 November 2020. Retrieved 22 January 2021. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  3. "Roclanda Product information". Union Register of medicinal products. Retrieved 3 March 2023.
  4. "Drug Approval Package: Rocklatan Ophthalmic Solution". U.S. Food and Drug Administration (FDA). 20 November 2019. Retrieved 2 June 2020.