Neuropeptide B/W receptor

Last updated
neuropeptides B/W receptor 1
Identifiers
SymbolNPBWR1
Alt. symbolsGPR7
NCBI gene 2831
HGNC 4522
OMIM 600730
RefSeq NM_005285
UniProt P48145
Other data
Locus Chr. 8 p22-q21.13
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Structures Swiss-model
Domains InterPro
neuropeptides B/W receptor 2
Identifiers
SymbolNPBWR2
Alt. symbolsGPR8
NCBI gene 2832
HGNC 4530
OMIM 600731
RefSeq NM_005286
UniProt P48146
Other data
Locus Chr. 20 q13.3
Search for
Structures Swiss-model
Domains InterPro

The neuropeptide B/W receptors are members of the G-protein coupled receptor superfamily of integral membrane proteins which bind the neuropeptides B and W. [1] These receptors are predominantly expressed in the CNS and have a number of functions including regulation of the secretion of cortisol. [2] [3]

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<span class="mw-page-title-main">Neuropeptides B/W receptor 1</span> Protein-coding gene in the species Homo sapiens

Neuropeptides B/W receptor 1, also known as NPBW1 and GPR7, is a human protein encoded by the NPBWR1 gene. As implied by its name, it and related gene NPBW2 are transmembranes protein that bind Neuropeptide B (NPB) and Neuropeptide W (NPW), both proteins expressed strongly in parts of the brain that regulate stress and fear including the extended amygdala and stria terminalis. When originally discovered in 1995, these receptors had no known ligands and were called GPR7 and GPR8, but at least three groups in the early 2000s independently identified their endogenous ligands, triggering the name change in 2005.

<span class="mw-page-title-main">Neuropeptides B/W receptor 2</span> Protein-coding gene in the species Homo sapiens

Neuropeptides B/W receptor 2, also known as NPBW2, is a human protein encoded by the NPBWR2 gene.

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<span class="mw-page-title-main">NPW</span> Protein-coding gene in the species Homo sapiens

NPW is a gene that in humans encodes Neuropeptide W protein.

<span class="mw-page-title-main">Neuropeptide W</span> Mammalian protein found in Homo sapiens

Neuropeptide W or preprotein L8 is a short human neuropeptide. Neuropeptide W acts as a ligand for two neuropeptide B/W receptors, NPBWR1 and NPBWR2, which are integrated in GPCRs family of alpha-helical transmembrane proteins.

References

  1. Tanaka H, Yoshida T, Miyamoto N, Motoike T, Kurosu H, Shibata K, Yamanaka A, Williams SC, Richardson JA, Tsujino N, Garry MG, Lerner MR, King DS, O'Dowd BF, Sakurai T, Yanagisawa M (2003). "Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6251–6. Bibcode:2003PNAS..100.6251T. doi: 10.1073/pnas.0837789100 . PMC   156358 . PMID   12719537.
  2. Mazzocchi G, Rebuffat P, Ziolkowska A, Rossi GP, Malendowicz LK, Nussdorfer GG (2005). "G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades". J. Clin. Endocrinol. Metab. 90 (6): 3466–71. doi: 10.1210/jc.2004-2132 . PMID   15797961.
  3. Singh G, Davenport AP (2006). "Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system". Br. J. Pharmacol. 148 (8): 1033–41. doi:10.1038/sj.bjp.0706825. PMC   1752024 . PMID   16847439.