Neuropeptides B/W receptor 2

NPBWR2
Identifiers
Aliases	NPBWR2 , GPR8, Neuropeptides B/W receptor 2, neuropeptides B and W receptor 2
External IDs	OMIM: 600731; HomoloGene: 128565; GeneCards: NPBWR2; OMA:NPBWR2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q13.33 Start 64,103,802 bp [1] End 64,107,565 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in primary visual cortex superior frontal gyrus prefrontal cortex dorsolateral prefrontal cortex Brodmann area 9 right frontal lobe pituitary gland anterior pituitary anterior cingulate cortex adrenal gland n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled opioid receptor activity neuropeptide binding protein binding G protein-coupled receptor activity signal transducer activity neuropeptide receptor activity peptide binding Cellular component integral component of membrane neuron projection plasma membrane integral component of plasma membrane membrane Biological process G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger neuropeptide signaling pathway signal transduction chemical synaptic transmission G protein-coupled opioid receptor signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2832 n/a Ensembl ENSG00000125522 ENSG00000277339 n/a UniProt P48146 n/a RefSeq (mRNA) NM_005286 n/a RefSeq (protein) NP_005277 n/a Location (UCSC) Chr 20: 64.1 – 64.11 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Neuropeptides B/W receptor 2, also known as NPBW2, is a human protein encoded by the NPBWR2 gene. ^[3]

The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded protein is similar in sequence to another G protein-coupled receptor (GPR7), and it is structurally similar to opioid and somatostatin receptors. This protein binds neuropeptides B and W. This gene is intronless and is expressed primarily in the frontal cortex of the brain. ^[3]

See also

• Neuropeptide B/W receptor

References

1. ENSG00000277339 GRCh38: Ensembl release 89: ENSG00000125522, ENSG00000277339 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: NPBWR2 neuropeptides B/W receptor 2".

Further reading

• O'Dowd BF, Scheideler MA, Nguyen T, et al. (1995). "The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain". Genomics. 28 (1): 84–91. doi:10.1006/geno.1995.1109. PMID   7590751.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Shimomura Y, Harada M, Goto M, et al. (2002). "Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8". J. Biol. Chem. 277 (39): 35826–32. doi: 10.1074/jbc.M205337200 . PMID   12130646.
• Brezillon S, Lannoy V, Franssen JD, et al. (2003). "Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8". J. Biol. Chem. 278 (2): 776–83. doi: 10.1074/jbc.M206396200 . PMID   12401809.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Tanaka H, Yoshida T, Miyamoto N, et al. (2003). "Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6251–6. Bibcode:2003PNAS..100.6251T. doi: 10.1073/pnas.0837789100 . PMC   156358 . PMID   12719537.
• Mazzocchi G, Rebuffat P, Ziolkowska A, et al. (2005). "G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades". J. Clin. Endocrinol. Metab. 90 (6): 3466–71. doi: 10.1210/jc.2004-2132 . PMID   15797961.

External links

• "Neuropeptide B/W Receptors: NPBW2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.