P/D1 cell

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P/D1 cells are cells lining the fundus of the human stomach that produce ghrelin. Removal of these cells in gastric bypass surgery has a profound impact on later appetite regulation. [1] These cells have also been shown to produce ghrelin's antagonistic hormone leptin. [2] PD/1 cells are equivalent to A-like cells in rats and X-type cells in dogs. These endocrine cells can be microscopically distinguished from other gastric endocrine cells through their round, compact, electron-dense secretory granules. [3]

References

  1. ↑ Inui A, Asakawa A, Bowers CY, et al. (2004). "Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ" . FASEB J. 18 (3): 439–56. doi: 10.1096/fj.03-0641rev . PMID   15003990. S2CID   15642270.
  2. ↑ Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau JP, Bortoluzzi MN, Moizo L, Lehy T, Guerre-Millo M, Le Marchand-Brustel Y, Lewin MJ (1998). "The stomach is a source of leptin". Nature. 394 (6695): 790–793. Bibcode:1998Natur.394..790B. doi:10.1038/29547. PMID   9723619. S2CID   4367948.
  3. ↑ Sakata, Ichiro; Sakai, Takafumi (14 March 2010). "Ghrelin Cells in the Gastrointestinal Tract". International Journal of Peptides. 2010: 1–7. doi: 10.1155/2010/945056 . PMC   2925405 . PMID   20798855.


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