Pharmaceutical ink

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Pharmaceutical ink is an ingestible form of water-based ink used on most medicine pills to indicate which drug it is, and/or how many milligrams the pill contains.

Water chemical compound

Water is a transparent, tasteless, odorless, and nearly colorless chemical substance, which is the main constituent of Earth's streams, lakes, and oceans, and the fluids of most living organisms. It is vital for all known forms of life, even though it provides no calories or organic nutrients. Its chemical formula is H2O, meaning that each of its molecules contains one oxygen and two hydrogen atoms, connected by covalent bonds. Water is the name of the liquid state of H2O at standard ambient temperature and pressure. It forms precipitation in the form of rain and aerosols in the form of fog. Clouds are formed from suspended droplets of water and ice, its solid state. When finely divided, crystalline ice may precipitate in the form of snow. The gaseous state of water is steam or water vapor. Water moves continually through the water cycle of evaporation, transpiration (evapotranspiration), condensation, precipitation, and runoff, usually reaching the sea.

Tablet (pharmacy) solid form for doses of drugs or medication to be taken orally

A tablet is a pharmaceutical dosage form. Tablets may be defined as the solid unit dosage form of medicament or medicaments with or without suitable excipients and prepared either by molding or by compression. It comprises a mixture of active substances and excipients, usually in powder form, pressed or compacted from a powder into a solid dose. The excipients can include diluents, binders or granulating agents, glidants and lubricants to ensure efficient tabletting; disintegrants to promote tablet break-up in the digestive tract; sweeteners or flavours to enhance taste; and pigments to make the tablets visually attractive or aid in visual identification of an unknown tablet. A polymer coating is often applied to make the tablet smoother and easier to swallow, to control the release rate of the active ingredient, to make it more resistant to the environment, or to enhance the tablet's appearance.

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History

The first U.S. patent for pharmaceutical inks was filed on 28 June 1966, and its method involved ethyl alcohol, shellac, titanium dioxide and propylene glycol.

Ethanol is a chemical compound, a simple alcohol with the chemical formula C
2
H
6
O
. Its formula can be also written as CH
3
CH
2
OH or C
2
H
5
OH, and is often abbreviated as EtOH. Ethanol is a volatile, flammable, colorless liquid with a slight characteristic odor. It is a psychoactive substance and is the principal type of alcohol found in alcoholic drinks.

Shellac resin secreted by the female lac bug, on trees in the forests of India and Thailand

Shellac is a resin secreted by the female lac bug, on trees in the forests of India and Thailand. It is processed and sold as dry flakes (pictured) and dissolved in alcohol to make liquid shellac, which is used as a brush-on colorant, food glaze and wood finish. Shellac functions as a tough natural primer, sanding sealant, tannin-blocker, odour-blocker, stain, and high-gloss varnish. Shellac was once used in electrical applications as it possesses good insulation qualities and it seals out moisture. Phonograph and 78 rpm gramophone records were made of it until they were replaced by vinyl long-playing records from the 1950s onwards.

Titanium dioxide chemical compound

Titanium dioxide, also known as titanium(IV) oxide or titania, is the naturally occurring oxide of titanium, chemical formula TiO
2
. When used as a pigment, it is called titanium white, Pigment White 6 (PW6), or CI 77891. Generally, it is sourced from ilmenite, rutile and anatase. It has a wide range of applications, including paint, sunscreen and food coloring. When used as a food coloring, it has E number E171. World production in 2014 exceeded 9 million metric tons. It has been estimated that titanium dioxide is used in two-thirds of all pigments, and pigments based on the oxide has been valued at $13.2 billion.

Most pharmaceutical inks since the early 1990s eliminate ethyl alcohol in favor of faster ink drying times, and may include methyl alcohol and isopropanol in addition to the traditional ingredients titanium dioxide and propylene glycol.

Methanol, also known as methyl alcohol among others, is a chemical with the formula CH3OH (a methyl group linked to a hydroxyl group, often abbreviated MeOH). Methanol acquired the name wood alcohol because it was once produced chiefly by the destructive distillation of wood. Today, methanol is mainly produced industrially by hydrogenation of carbon monoxide.

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Ethylene glycol chemical compound

Ethylene glycol (IUPAC name: ethane-1,2-diol) is an organic compound with the formula (CH2OH)2. It is mainly used for two purposes, as a raw material in the manufacture of polyester fibers and for antifreeze formulations. It is an odorless, colorless, sweet-tasting, viscous liquid. Ethylene glycol is toxic. Household pets are especially susceptible to ethylene glycol poisoning from vehicle antifreeze leaks.

Glycerol chemical compound

Glycerol is a simple polyol compound. It is a colorless, odorless, viscous liquid that is sweet-tasting and non-toxic. The glycerol backbone is found in many lipids which are known as glycerides. It is widely used in the food industry as a sweetener and humectant in pharmaceutical formulations. Glycerol has three hydroxyl groups that are responsible for its solubility in water and its hygroscopic nature.

Propylene glycol chemical compound

Propylene glycol (IUPAC name: propane-1,2-diol) is a synthetic organic compound with the chemical formula C3H8O2. It is a viscous, colorless liquid which is nearly odorless but possesses a faintly sweet taste. Chemically it is classed as a diol and is miscible with a broad range of solvents, including water, acetone, and chloroform.

Tincture

A tincture is typically an extract of plant or animal material dissolved in ethyl alcohol (ethanol). Solvent concentrations of 25–60% are common, but may run as high as 90%. In chemistry, a tincture is a solution that has ethanol as its solvent. In herbal medicine, alcoholic tinctures are made with various ethanol concentrations, 20% being the most common.

Marker pen type of writing tool

A marker pen, fineliner, marking pen, felt-tip marker, felt-tip pen, flow marker, texta, sketch pen or koki, is a pen which has its own ink source and a tip made of porous, pressed fibers such as felt. A permanent marker consists of a container and a core of an absorbent material. This filling serves as a carrier for the ink. The upper part of the marker contains the nib that was made in earlier time of a hard felt material, and a cap to prevent the marker from drying out. Until the early 1990s the most common solvents that were used for the ink were toluene and xylene. These two substances are both harmful and characterized by a very strong smell. Today, the ink is usually made on the basis of alcohols. Markers may be waterproof, dry-erase, wet-erase, or permanent.

Permanent marker

A permanent marker or indelible marker is a type of marker pen that is used to create permanent or semi-permanent writing on an object. In general, the ink comprises a main carrier solvent, a glyceride, a pyrrolidone, a resin and a colorant, making it water resistant. It is capable of writing on a variety of surfaces from paper to metal to stone. They come in a variety of tip sizes, shapes, and colors. Like spray paint, these markers contain volatile organic compounds which evaporate to dry the ink. Due to compounds such as toluene and xylene often being present in permanent markers, they have a potential for abuse as a recreational drug.

A diol is a chemical compound containing two hydroxyl groups. An aliphatic diol is also called a glycol. This pairing of functional groups is pervasive, and many subcategories have been identified.

Antifreeze coolant additive which reduces the freezing point of water

An antifreeze is an additive which lowers the freezing point of a water-based liquid and increases its boiling point. An antifreeze mixture is used to achieve freezing-point depression for cold environments and also achieves boiling-point elevation ("anti-boil") to allow higher coolant temperature. Freezing and boiling points are colligative properties of a solution, which depend on the concentration of the dissolved substance.

Propylene oxide chemical compound

Propylene oxide is an organic compound with the molecular formula CH3CHCH2O. This colourless volatile liquid with an odour resembling ether, is produced on a large scale industrially. Its major application is its use for the production of polyether polyols for use in making polyurethane plastics. It is a chiral epoxide, although it is commonly used as a racemic mixture.

Fog machine

A fog machine, fog generator, or smoke machine is a device that emits a dense vapor that appears similar to fog or smoke. This artificial fog is most commonly used in professional entertainment applications, but smaller, more affordable fog machines are becoming common for personal use. Fog machines can also be found in use in a variety of industrial, training, and some military applications. Typically, fog is created by vaporizing proprietary water and glycol-based or glycerin-based fluids or through the atomization of mineral oil. This fluid vaporizes or atomizes inside the fog machine. Upon exiting the fog machine and mixing with cooler outside air the vapor condenses, resulting in a thick visible fog.

Pharmaceutical glaze is an alcohol-based solution of various types of food-grade shellac. The shellac is derived from the raw material sticklac, which is a resin scraped from the branches of trees left from when the small insect, Kerria lacca, creates a hard, waterproof cocoon. When used in food and confections, it is also known as confectioner's glaze, resinous glaze, pure food glaze, natural glaze, or confectioner's resin.

Glycol ethers are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used in paints and cleaners. These solvents typically have a higher boiling point, together with the favorable solvent properties of lower-molecular weight ethers and alcohols. The word "Cellosolve" was registered in 1924 as a United States trademark by Carbide & Carbon Chemicals Corp. for "Solvents for Gums, Resins, Cellulose Esters, and the Like",; the first one was ethyl cellosolve, with the name now generic for glycol ethers.

Propylene carbonate chemical compound

Propylene carbonate (often abbreviated PC) is an organic compound with the formula C4H6O3. It is a cyclic carbonate ester derived from propylene glycol. This colorless and odorless liquid is useful as a polar, aprotic solvent. Propylene carbonate is chiral, but is used exclusively as the racemic mixture in most contexts.

Dimethyl carbonate chemical compound

Dimethyl carbonate (DMC) is an organic compound with the formula OC(OCH3)2. It is a colourless, flammable liquid. It is classified as a carbonate ester. This compound has found use as a methylating agent and more recently as a solvent that is exempt from the restrictions placed on most volatile organic compounds (VOCs) in the US. Dimethyl carbonate is often considered to be a green reagent.

A trap primer is a plumbing device or valve that adds water to traps. The water seals in traps are needed to prevent sewer gases from entering buildings, but because this water is exposed to the air, it is subject to evaporation over time in infrequently used floor drains, leading to the release of sewer gas into the environment. The trap primer mitigates this problem by injecting water, either directly or indirectly, into the trap to maintain the water seal indefinitely.

Tattoo inks consist of pigments combined with a carrier, and are used in tattooing.

Commodity chemicals are a group of chemicals that are made on a very large scale to satisfy global markets. The average prices of commodity chemicals are regularly published in the chemical trade magazines and web sites such as Chemical Week and ICIS. There have been several studies of the scale and complexity of this market for example in the USA.

Extraction (chemistry) separation process consisting in the separation of a substance from a matrix; types: liquid-liquid extraction, solid-phase extraction, solid-phase microextraction, Soxhlet extraction, fizzy extraction

Extraction in chemistry is a separation process consisting in the separation of a substance from a matrix. It includes Liquid-liquid extraction, and Solid phase extraction. The distribution of a solute between two phases is an equilibrium condition described by partition theory. This is based on exactly how the analyte move from the water into an organic layer.

Tavaborole chemical compound

Tavaborole is a topical antifungal medication for the treatment of onychomycosis, a fungal infection of the nail and nail bed. Tavaborole began its Phase 3 trials in December 2010 and was approved by the US FDA in July 2014. Tavaborole inhibits an essential fungal enzyme, leucyl-tRNA synthetase, that is required for protein synthesis. The inhibition of protein synthesis leads to termination of cell growth and then cell death, eliminating the fungal infection.

Chalkboard paint is a specialized paint that creates a chalkboard like coating that can be utilized as a writing surface in the same manner as a traditional chalkboard or blackboard. Chalkboard paint is commonly made out of a mixture of talc, acrylic, water, glycol, titanium dioxide, carbon black, opacifiers, silica, and esters. It may also contain acetone, propane, butane, xylene, ethylbenzene, amorphous silica, n-butyl acetate, and propylene glycol methyl ether acetate which are industrial standard ingredients used in inks and paints as thinners, olfactory, and pigmentation agents.