Phenylalanine/tyrosine ammonia-lyase

Phenylalanine/tyrosine ammonia-lyase
Identifiers
EC no.	4.3.1.25
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Phenylalanine/tyrosine ammonia-lyase (EC 4.3.1.25, PTAL, bifunctional PAL) is an enzyme with systematic name L-phenylalanine(or L-tyrosine):trans-cinnamate(or trans-p-hydroxycinnamate) ammonia-lyase. ^{[1] [2] [3] [4] [5]} This enzyme catalyses the following chemical reaction

(1) L-phenylalanine ${\displaystyle \rightleftharpoons }$ trans-cinnamate + NH₃

(2) L- tyrosine ${\displaystyle \rightleftharpoons }$trans-p-hydroxycinnamate + NH₃

This enzyme is a member of the aromatic amino acid lyase family.

References

1. Rösler J, Krekel F, Amrhein N, Schmid J (January 1997). "Maize phenylalanine ammonia-lyase has tyrosine ammonia-lyase activity". Plant Physiology. 113 (1): 175–9. doi:10.1104/pp.113.1.175. PMC   158128 . PMID   9008393.
2. Watts KT, Mijts BN, Lee PC, Manning AJ, Schmidt-Dannert C (December 2006). "Discovery of a substrate selectivity switch in tyrosine ammonia-lyase, a member of the aromatic amino acid lyase family". Chemistry & Biology. 13 (12): 1317–26. doi:10.1016/j.chembiol.2006.10.008. PMID   17185227.
3. Louie GV, Bowman ME, Moffitt MC, Baiga TJ, Moore BS, Noel JP (December 2006). "Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases". Chemistry & Biology. 13 (12): 1327–38. doi:10.1016/j.chembiol.2006.11.011. PMC   2859959 . PMID   17185228.
4. Schwede TF, Rétey J, Schulz GE (April 1999). "Crystal structure of histidine ammonia-lyase revealing a novel polypeptide modification as the catalytic electrophile". Biochemistry. 38 (17): 5355–61. doi:10.1021/bi982929q. PMID   10220322.
5. Barros J, Serrani-Yarce JC, Chen F, Baxter D, Venables BJ, Dixon RA (May 2016). "Role of bifunctional ammonia-lyase in grass cell wall biosynthesis". Nature Plants. 2 (6) 16050. Bibcode:2016NatPl...216050B. doi:10.1038/nplants.2016.50. PMID   27255834.

External links

• Phenylalanine/tyrosine+ammonia-lyase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)