Prostamide/prostaglandin F2alpha synthase

Prostamide/prostaglandin F2alpha synthase
Identifiers
EC no.	1.11.1.20
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Prostamide/prostaglandin F2alpha synthase (EC 1.11.1.20, prostamide/PGF synthase, prostamide F synthase, prostamide/prostaglandin F synthase, tPGF synthase) is an enzyme with systematic name thioredoxin:(5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate oxidoreductase . ^{[1] [2]} This enzyme catalyses the following chemical reaction

thioredoxin +

 

prostaglandin H2

 

 

 

 

 

 

thioredoxin
disulfide

 

+

 

prostaglandin F2alpha

This enzyme uses thioredoxin as a reducing agent to convert peroxides to diols. ^[3]

References

1. Moriuchi H, Koda N, Okuda-Ashitaka E, Daiyasu H, Ogasawara K, Toh H, Ito S, Woodward DF, Watanabe K (January 2008). "Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily". The Journal of Biological Chemistry. 283 (2): 792–801. doi: 10.1074/jbc.M705638200 . PMID   18006499.
2. Yoshikawa K, Takei S, Hasegawa-Ishii S, Chiba Y, Furukawa A, Kawamura N, Hosokawa M, Woodward DF, Watanabe K, Shimada A (January 2011). "Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system". Brain Research. 1367: 22–32. doi:10.1016/j.brainres.2010.10.019. PMID   20950588.
3. Enzyme 1.11.1.20 at KEGG Pathway Database.

External links

• Prostamide/prostaglandin+F2alpha+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)