Pyrimethamine/dapsone

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Pyrimethamine/dapsone
Combination of
Pyrimethamine Antimalarial
Dapsone Antimicrobial
Clinical data
Trade names Maloprim

Pyrimethamine/dapsone, sold under the brand name Maloprim, is a combination medication used to treat malaria and pneumocystis jiroveci pneumonia. [1] [2] It contains a combination of pyrimethamine (Daraprim), an antimalarial, and dapsone, a sulfone. It is especially useful for preventing reactivation of latent infections in immunocompromised adults. [3] However, its use is limited by the possibility of hematologic toxicity. [3]

References

  1. ↑ Pividal J, Viktinski V, Streat E, Schapira A (June 1992). "Efficacy of dapsone with pyrimethamine (Maloprim) for malaria prophylaxis in Maputo, Mozambique". East African Medical Journal. 69 (6): 303–305. PMID   1505413.
  2. ↑ "Pyrimethamine (Monograph)". Drugs.com. Retrieved 2025-09-17.
  3. 1 2 Aronson JK, ed. (2006). "Pyrimethamine". Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions. pp. 2984–2988. doi:10.1016/B0-44-451005-2/00737-3. ISBN   978-0-444-51005-1.
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