Quinate/shikimate dehydrogenase

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Quinate/shikimate dehydrogenase
Identifiers
EC no. 1.1.1.282
Databases
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BRENDA BRENDA entry
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Quinate/shikimate dehydrogenase (EC 1.1.1.282, YdiB) is an enzyme with systematic name L-quinate:NAD(P)+ 3-oxidoreductase. [1] [2] This enzyme catalyses the following two chemical reactions: [3]

 
 
 
H+
Quinate/shikimate dehydrogenase
 
H+
 
 
 
 
 
H+
Quinate/shikimate dehydrogenase
 
H+
 
 

This is the second shikimate dehydrogenase enzyme found in Escherichia coli and differs from EC 1.1.1.25, shikimate dehydrogenase, in that it can use both quinic acid and shikimic acid as substrates, and either NAD+ or NADP+ as cofactor.

References

  1. Michel G, Roszak AW, Sauvé V, Maclean J, Matte A, Coggins JR, Cygler M, Lapthorn AJ (May 2003). "Structures of shikimate dehydrogenase AroE and its Paralog YdiB. A common structural framework for different activities". The Journal of Biological Chemistry. 278 (21): 19463–72. doi: 10.1074/jbc.M300794200 . PMID   12637497.
  2. Benach J, Lee I, Edstrom W, Kuzin AP, Chiang Y, Acton TB, Montelione GT, Hunt JF (May 2003). "The 2.3-A crystal structure of the shikimate 5-dehydrogenase orthologue YdiB from Escherichia coli suggests a novel catalytic environment for an NAD-dependent dehydrogenase". The Journal of Biological Chemistry. 278 (21): 19176–82. doi: 10.1074/jbc.M301348200 . PMID   12624088.
  3. Enzyme 1.1.1.282 at KEGG Pathway Database.