Relaxin/insulin-like family peptide receptor 4

RXFP4
Identifiers
Aliases	RXFP4 , GPCR142, GPR100, RLN3R2, RXFPR4, Relaxin/insulin-like family peptide receptor 4, relaxin/insulin like family peptide receptor 4, relaxin family peptide/INSL5 receptor 4
External IDs	OMIM: 609043 MGI: 2182926 HomoloGene: 18775 GeneCards: RXFP4
Gene location (Human)
Chr.	Chromosome 1 (human)
End	155,943,087 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	88,560,449 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; rectum; ; duodenum; ; monocyte; ; bone marrow; ; blood; ; appendix; ; gastric mucosa; ; smooth muscle tissue; ; cerebellum;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; G protein-coupled receptor activity ; signal transducer activity ; galanin receptor activity ; G protein-coupled peptide receptor activity ;
Cellular component	integral component of membrane ; plasma membrane ; integral component of plasma membrane ; membrane ;
Biological process	phospholipase C-activating G protein-coupled receptor signaling pathway ; positive regulation of feeding behavior ; signal transduction ; adenylate cyclase-modulating G protein-coupled receptor signaling pathway ; neuropeptide signaling pathway ; G protein-coupled receptor signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	339403
	242093
	ENSG00000173080
	ENSMUSG00000049741
	Q8TDU9
	Q7TQP4
	NM_181885
	NM_181817
	NP_871001
	NP_861538
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 19, 2023

Relaxin/insulin-like family peptide receptor 4, also known as RXFP4, is a human G-protein coupled receptor.^[5]

Function

GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003).[supplied by OMIM]^[5]

Related Research Articles

<span class="mw-page-title-main">Relaxin</span> Protein hormone

Relaxin is a protein hormone of about 6000 Da, first described in 1926 by Frederick Hisaw.

The relaxin receptors are a subclass of four closely related G protein-coupled receptors (GPCR) that bind relaxin peptide hormones.

Hydroxycarboxylic acid receptor 3 (HCA₃), also known as niacin receptor 2 (NIACR2) and GPR109B, is a protein which in humans is encoded by the HCAR3 gene. HCA₃, like the other hydroxycarboxylic acid receptors HCA₁ and HCA₂, is a G_i/o-coupled G protein-coupled receptor (GPCR). The primary endogenous agonists of HCA₃ are 3-hydroxyoctanoic acid and kynurenic acid. HCA₃ is also a low-affinity biomolecular target for niacin (aka nicotinic acid).

G protein-coupled receptor 64 also known as HE6 is a protein encoded by the ADGRG2 gene. GPR64 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Hydroxycarboxylic acid receptor 1 (HCA₁), formerly known as G protein-coupled receptor 81 (GPR81), is a protein that in humans is encoded by the HCAR1 gene. HCA₁, like the other hydroxycarboxylic acid receptors HCA₂ and HCA₃, is a G_i/o-coupled G protein-coupled receptor (GPCR). The primary endogenous agonist of HCA₁ is lactic acid (and its conjugate base, lactate).

Relaxin/insulin-like family peptide receptor 3, also known as RXFP3, is a human G-protein coupled receptor.

G protein-coupled receptor 126 also known as VIGR and DREG is a protein encoded by the ADGRG6 gene. GPR126 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Relaxin/insulin-like family peptide receptor 1, also known as RXFP1, is a human G protein coupled receptor that is one of the relaxin receptors. It is a rhodopsin-like GPCR which is unusual in this class as it contains a large extracellular binding and signalling domain. Some reports suggest that RXFP1 forms homodimers, however the most recent evidence indicates that relaxin binds a non-homodimer of RXFP1.

G protein-coupled receptor 128 is a protein encoded by the ADGRG7 gene. GPR128 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Probable G-protein coupled receptor 146 is a protein that in humans is encoded by the GPR146 gene. It has been identified as a possible receptor for C-peptide.

G protein-coupled receptor 112 is a protein encoded by the ADGRG4 gene. GPR112 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

G protein-coupled receptor 119 also known as GPR119 is a G protein-coupled receptor that in humans is encoded by the GPR119 gene.

G protein-coupled receptor 114 is a protein encoded by the ADGRG5 gene. GPR114 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

G-protein coupled receptor 97 also known as adhesion G protein-coupled receptor G3 (ADGRG3) is a protein that in humans is encoded by the ADGRG3 gene. GPR97 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Probable G-protein coupled receptor 142 is a protein that in humans is encoded by the GPR142 gene.

Relaxin/insulin-like family peptide receptor 2, also known as RXFP2, is a human G-protein coupled receptor.

Secretin receptor family consists of secretin receptors regulated by peptide hormones from the glucagon hormone family. The family is different from adhesion G protein-coupled receptors.

Rhodopsin-like receptors are a family of proteins that comprise the largest group of G protein-coupled receptors.

Insulin-like peptide 5 (INSL5) is a protein that in humans is encoded by the INSL5 gene.

<span class="mw-page-title-main">Relaxin family peptide hormones</span> Protein family

Relaxin family peptide hormones in humans are represented by seven members: three relaxin-like (RLN) and four insulin-like (INSL) peptides: RLN1, RLN2, RNL3, INSL3, INSL4, INSL5, INSL6. This subdivision into two classes is based primarily on early findings, and does not reflect the evolutionary origins or physiological differences between peptides. For example, it is known that the genes coding for RLN3 and INSL5 arose from one ancestral gene, and INSL3 shares origin with RLN2 and its multiple duplicates: RLN1, INSL4, INSL6.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000173080 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049741 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: RXFP4 relaxin/insulin-like family peptide receptor 4".

External links

"Relaxin Family Peptide Receptors: RXFP4". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ (May 2005). "Receptors for relaxin family peptides". Annals of the New York Academy of Sciences. 1041: 61–76. Bibcode:2005NYASA1041...61B. doi:10.1196/annals.1282.010. PMID 15956688. S2CID 1185573.
Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ (March 2006). "International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides". Pharmacological Reviews. 58 (1): 7–31. doi:10.1124/pr.58.1.9. PMID 16507880. S2CID 7466039.
Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (June 2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. S2CID 7116392.
Liu C, Chen J, Sutton S, Roland B, Kuei C, Farmer N, Sillard R, Lovenberg TW (December 2003). "Identification of relaxin-3/INSL7 as a ligand for GPCR142". The Journal of Biological Chemistry. 278 (50): 50765–70. doi: 10.1074/jbc.M308996200 . PMID 14522967.
Boels K, Schaller HC (November 2003). "Identification and characterisation of GPR100 as a novel human G-protein-coupled bradykinin receptor". British Journal of Pharmacology. 140 (5): 932–8. doi:10.1038/sj.bjp.0705521. PMC 1574110 . PMID 14530218.
Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (November 2003). "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives". FEBS Letters. 554 (3): 381–8. doi:10.1016/S0014-5793(03)01196-7. PMID 14623098. S2CID 11563502.
Liu C, Chen J, Kuei C, Sutton S, Nepomuceno D, Bonaventure P, Lovenberg TW (January 2005). "Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7". Molecular Pharmacology. 67 (1): 231–40. doi:10.1124/mol.104.006700. PMID 15465925. S2CID 25164369.
Liu C, Kuei C, Sutton S, Chen J, Bonaventure P, Wu J, Nepomuceno D, Kamme F, Tran DT, Zhu J, Wilkinson T, Bathgate R, Eriste E, Sillard R, Lovenberg TW (January 2005). "INSL5 is a high affinity specific agonist for GPCR142 (GPR100)". The Journal of Biological Chemistry. 280 (1): 292–300. doi: 10.1074/jbc.M409916200 . PMID 15525639.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000173080 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049741 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: RXFP4 relaxin/insulin-like family peptide receptor 4".

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[2]

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[5]

Relaxin/insulin-like family peptide receptor 4

Contents

Function

See also

Related Research Articles

References

External links

Further reading