Relaxin/insulin-like family peptide receptor 4

RXFP4
Identifiers
Aliases	RXFP4 , GPCR142, GPR100, RLN3R2, RXFPR4, Relaxin/insulin-like family peptide receptor 4, relaxin/insulin like family peptide receptor 4, relaxin family peptide/INSL5 receptor 4
External IDs	OMIM: 609043; MGI: 2182926; HomoloGene: 18775; GeneCards: RXFP4; OMA:RXFP4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q22 Start 155,941,638 bp [1] End 155,943,087 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F1 Start 88,559,205 bp [2] End 88,560,449 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon sural nerve rectum granulocyte duodenum monocyte bone marrow blood appendix gastric mucosa Top expressed in embryo More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding G protein-coupled receptor activity signal transducer activity galanin receptor activity G protein-coupled peptide receptor activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of feeding behavior signal transduction adenylate cyclase-modulating G protein-coupled receptor signaling pathway neuropeptide signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 339403 242093 Ensembl ENSG00000173080 ENSMUSG00000049741 UniProt Q8TDU9 Q7TQP4 RefSeq (mRNA) NM_181885 NM_181817 RefSeq (protein) NP_871001 NP_861538 Location (UCSC) Chr 1: 155.94 – 155.94 Mb Chr 3: 88.56 – 88.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Relaxin/insulin-like family peptide receptor 4, also known as RXFP4, is a human G-protein coupled receptor. ^[5]

Function

GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003).[supplied by OMIM] ^[5]

See also

• Relaxin receptor

References

1. GRCh38: Ensembl release 89: ENSG00000173080 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000049741 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RXFP4 relaxin/insulin-like family peptide receptor 4".

External links

• "Relaxin Family Peptide Receptors: RXFP4". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.

Further reading

• Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ (May 2005). "Receptors for relaxin family peptides". Annals of the New York Academy of Sciences. 1041 (1): 61–76. Bibcode:2005NYASA1041...61B. doi:10.1196/annals.1282.010. PMID   15956688. S2CID   1185573.
• Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ (March 2006). "International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides". Pharmacological Reviews. 58 (1): 7–31. doi:10.1124/pr.58.1.9. PMID   16507880. S2CID   7466039.
• Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (June 2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID   12044878. S2CID   7116392.
• Liu C, Chen J, Sutton S, Roland B, Kuei C, Farmer N, Sillard R, Lovenberg TW (December 2003). "Identification of relaxin-3/INSL7 as a ligand for GPCR142". The Journal of Biological Chemistry. 278 (50): 50765–70. doi: 10.1074/jbc.M308996200 . PMID   14522967.
• Boels K, Schaller HC (November 2003). "Identification and characterisation of GPR100 as a novel human G-protein-coupled bradykinin receptor". British Journal of Pharmacology. 140 (5): 932–8. doi:10.1038/sj.bjp.0705521. PMC   1574110 . PMID   14530218.
• Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (November 2003). "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives". FEBS Letters. 554 (3): 381–8. doi: 10.1016/S0014-5793(03)01196-7 . PMID   14623098. S2CID   11563502.
• Liu C, Chen J, Kuei C, Sutton S, Nepomuceno D, Bonaventure P, Lovenberg TW (January 2005). "Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7". Molecular Pharmacology. 67 (1): 231–40. doi:10.1124/mol.104.006700. PMID   15465925. S2CID   25164369.
• Liu C, Kuei C, Sutton S, Chen J, Bonaventure P, Wu J, Nepomuceno D, Kamme F, Tran DT, Zhu J, Wilkinson T, Bathgate R, Eriste E, Sillard R, Lovenberg TW (January 2005). "INSL5 is a high affinity specific agonist for GPCR142 (GPR100)". The Journal of Biological Chemistry. 280 (1): 292–300. doi: 10.1074/jbc.M409916200 . PMID   15525639.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.