Route 22 is a common name for roads and highways in many countries.
Route 22 may also refer to:
- Route 22 (MTA Maryland), a bus route in Baltimore, Maryland, U.S.
- Route 22 (MBTA), a bus route in Boston, US
- London Buses route 22, a bus route in London, UK
- 22 Fillmore, a bus route in San Francisco
This disambiguation page lists articles associated with the title Route 22.
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