SRSF2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | SRSF2 , PR264, SC-35, SC35, SFRS2, SFRS2A, SRp30b, serine/arginine-rich splicing factor 2, serine and arginine rich splicing factor 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 600813 MGI: 98284 HomoloGene: 37721 GeneCards: SRSF2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Splicing factor, arginine/serine-rich 2 is a protein that in humans is encoded by the SFRS2 gene. [5] [6] [7] MDS-associated splicing factor SRSF2 affects the expression of Class III and Class IV isoforms and perturbs granulopoiesis and SRSF2 P95H promotes Class IV splicing by binding to key ESE sequences in CSF3R exon 17, and that SRSF2, when mutated, contributes to dysgranulopoiesis. [8]
SFRS2 has been shown to interact with CDC5L [9] and ASF/SF2. [10]
Splicing factor U2AF 65 kDa subunit is a protein that in humans is encoded by the U2AF2 gene.
snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein that in humans is encoded by the SNRNP70 gene. snRNP70 is a small nuclear ribonucleoprotein that associates with U1 spliceosomal RNA, forming the U1snRNP a core component of the spliceosome. The U1-70K protein and other components of the spliceosome complex form detergent-insoluble aggregates in both sporadic and familial human cases of Alzheimer's disease. U1-70K co-localizes with Tau in neurofibrillary tangles in Alzheimer's disease.
Splicing factor U2AF 35 kDa subunit is a protein that in humans is encoded by the U2AF1 gene.
Serine/arginine-Rich Splicing Factor (SRSF) protein kinase-1 SRPK1 is an enzyme that in humans is encoded by the SRPK1 gene.
Splicing factor, arginine/serine-rich 3 is a protein that in humans is encoded by the SFRS3 gene.
Splicing factor 3B subunit 1 is a protein that in humans is encoded by the SF3B1 gene.
Splicing factor, arginine/serine-rich 6 is a protein that in humans is encoded by the SFRS6 gene.
Serine/arginine-rich splicing factor 7 (SRSF7) also known as splicing factor, arginine/serine-rich 7 (SFRS7) or splicing factor 9G8 is a protein that in humans is encoded by the SRSF7 gene.
Splicing factor, arginine/serine-rich 9, also known as SFRS9, is a human gene encoding an SR protein involved in splice site selection in alternative splicing.
Splicing factor, arginine/serine-rich 5 is a protein that in humans is encoded by the SFRS5 gene.
Transcription elongation regulator 1, also known as TCERG1, is a protein which in humans is encoded by the TCERG1 gene.
FUS-interacting serine-arginine-rich protein 1 is a protein that in humans is encoded by the SFRS13A gene.
Splicing factor, arginine/serine-rich 4 is a protein that in humans is encoded by the SFRS4 gene.
Probable ATP-dependent RNA helicase DDX6 is an enzyme that in humans is encoded by the DDX6 gene.
Eukaryotic initiation factor 4A-III is a protein that in humans is encoded by the EIF4A3 gene.
Splicing factor, arginine/serine-rich 12 is a protein that in humans is encoded by the SFRS12 gene.
Probable ATP-dependent RNA helicase DDX23 is an enzyme that in humans is encoded by the DDX23 gene.
SFRS2-interacting protein is a protein that in humans is encoded by the SFRS2IP gene.
Splicing factor, arginine/serine-rich 11 is a protein that in humans is encoded by the SFRS11 gene.
Serine/arginine-rich splicing factor 1 (SRSF1) also known as alternative splicing factor 1 (ASF1), pre-mRNA-splicing factor SF2 (SF2) or ASF1/SF2 is a protein that in humans is encoded by the SRSF1 gene. ASF/SF2 is an essential sequence specific splicing factor involved in pre-mRNA splicing. SRSF1 is the gene that codes for ASF/SF2 and is found on chromosome 17. The resulting splicing factor is a protein of approximately 33 kDa. ASF/SF2 is necessary for all splicing reactions to occur, and influences splice site selection in a concentration-dependent manner, resulting in alternative splicing. In addition to being involved in the splicing process, ASF/SF2 also mediates post-splicing activities, such as mRNA nuclear export and translation.