SRSF2

SRSF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KN4, 2LEA, 2LEB, 2LEC
Identifiers
Aliases	SRSF2 , PR264, SC-35, SC35, SFRS2, SFRS2A, SRp30b, serine/arginine-rich splicing factor 2, serine and arginine rich splicing factor 2
External IDs	OMIM: 600813; MGI: 98284; HomoloGene: 37721; GeneCards: SRSF2; OMA:SRSF2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q25.1 Start 76,734,115 bp [1] End 76,737,333 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 E2|11 81.49 cM Start 116,849,901 bp [2] End 116,853,094 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia embryo tendon of biceps brachii thymus ventricular zone ganglionic eminence granulocyte male germ cell sperm lymph node Top expressed in corneal stroma otic placode tail of embryo otic vesicle Ileal epithelium superior surface of tongue genital tubercle medial ganglionic eminence saccule lactiferous gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription corepressor activity protein binding nucleic acid binding RNA binding protein kinase C binding pre-mRNA binding Cellular component PML body nuclear speck nucleoplasm extracellular exosome nucleus cytosol spliceosomal complex interchromatin granule cytoplasm Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA processing mRNA export from nucleus RNA splicing mRNA 3'-end processing RNA export from nucleus negative regulation of nucleic acid-templated transcription mitotic cell cycle regulation of alternative mRNA splicing, via spliceosome response to vitamin E regulation of RNA splicing mRNA cis splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6427 20382 Ensembl ENSG00000161547 ENSMUSG00000034120 UniProt Q01130 Q62093 RefSeq (mRNA) NM_001195427 NM_003016 NM_011358 RefSeq (protein) NP_001182356 NP_003007 NP_035488 Location (UCSC) Chr 17: 76.73 – 76.74 Mb Chr 11: 116.85 – 116.85 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serine/arginine-rich splicing factor 2 is a protein that in humans is encoded by the SRSF2 gene. ^{[5] [6] [7]} MDS-associated splicing factor SRSF2 affects the expression of Class III and Class IV isoforms and perturbs granulopoiesis and SRSF2 P95H promotes Class IV splicing by binding to key ESE sequences in CSF3R exon 17, and that SRSF2, when mutated, contributes to dysgranulopoiesis. ^[8]

Interactions

SFRS2 has been shown to interact with CDC5L ^[9] and ASF/SF2. ^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000161547 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034120 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bermingham JR, Arden KC, Naumova AK, Sapienza C, Viars CS, Fu XD, et al. (September 1995). "Chromosomal localization of mouse and human genes encoding the splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2)". Genomics. 29 (1): 70–79. doi: 10.1006/geno.1995.1216 . PMID   8530103.
6. Fu XD, Maniatis T (April 1992). "Isolation of a complementary DNA that encodes the mammalian splicing factor SC35". Science. 256 (5056): 535–538. Bibcode:1992Sci...256..535F. doi:10.1126/science.1373910. PMID   1373910.
7. "Entrez Gene: SFRS2 splicing factor, arginine/serine-rich 2".
8. Wang BA, Mehta HM, Penumutchu SR, Tolbert BS, Cheng C, Kimmel M, et al. (October 2022). "Alternatively spliced CSF3R isoforms in SRSF2 P95H mutated myeloid neoplasms". Leukemia. 36 (10): 2499–2508. doi:10.1038/s41375-022-01672-4. PMID   35941213. S2CID   251408524.
9. Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–6581. doi:10.1093/emboj/19.23.6569. PMC   305846 . PMID   11101529.
10. Zhang WJ, Wu JY (October 1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Molecular and Cellular Biology. 16 (10): 5400–5408. doi:10.1128/MCB.16.10.5400. PMC   231539 . PMID   8816452.

Further reading

• Sureau A, Soret J, Vellard M, Crochet J, Perbal B (December 1992). "The PR264/c-myb connection: expression of a splicing factor modulated by a nuclear protooncogene". Proceedings of the National Academy of Sciences of the United States of America. 89 (24): 11683–11687. Bibcode:1992PNAS...8911683S. doi: 10.1073/pnas.89.24.11683 . PMC   50620 . PMID   1465383.
• Vellard M, Sureau A, Soret J, Martinerie C, Perbal B (April 1992). "A potential splicing factor is encoded by the opposite strand of the trans-spliced c-myb exon". Proceedings of the National Academy of Sciences of the United States of America. 89 (7): 2511–2515. Bibcode:1992PNAS...89.2511V. doi: 10.1073/pnas.89.7.2511 . PMC   48691 . PMID   1557353.
• Zahler AM, Lane WS, Stolk JA, Roth MB (May 1992). "SR proteins: a conserved family of pre-mRNA splicing factors". Genes & Development. 6 (5): 837–847. doi: 10.1101/gad.6.5.837 . PMID   1577277.
• DuBridge RB, Tang P, Hsia HC, Leong PM, Miller JH, Calos MP (January 1987). "Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system". Molecular and Cellular Biology. 7 (1): 379–387. doi:10.1128/mcb.7.1.379. PMC   365079 . PMID   3031469.
• Tacke R, Manley JL (July 1995). "The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities". The EMBO Journal. 14 (14): 3540–3551. doi:10.1002/j.1460-2075.1995.tb07360.x. PMC   394422 . PMID   7543047.
• Luznik L, Martone ME, Kraus G, Zhang Y, Xu Y, Ellisman MH, Wong-Staal F (July 1995). "Localization of human immunodeficiency virus Rev in transfected and virus-infected cells". AIDS Research and Human Retroviruses. 11 (7): 795–804. doi:10.1089/aid.1995.11.795. PMID   7546906. S2CID   24916512.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Kohtz JD, Jamison SF, Will CL, Zuo P, Lührmann R, Garcia-Blanco MA, Manley JL (March 1994). "Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors". Nature. 368 (6467): 119–124. Bibcode:1994Natur.368..119K. doi:10.1038/368119a0. PMID   8139654. S2CID   4283089.
• Wu JY, Maniatis T (December 1993). "Specific interactions between proteins implicated in splice site selection and regulated alternative splicing". Cell. 75 (6): 1061–1070. doi:10.1016/0092-8674(93)90316-I. PMID   8261509. S2CID   22951690.
• Sureau A, Perbal B (February 1994). "Several mRNAs with variable 3' untranslated regions and different stability encode the human PR264/SC35 splicing factor". Proceedings of the National Academy of Sciences of the United States of America. 91 (3): 932–936. Bibcode:1994PNAS...91..932S. doi: 10.1073/pnas.91.3.932 . PMC   521427 . PMID   8302870.
• Fu XD (September 1993). "Specific commitment of different pre-mRNAs to splicing by single SR proteins". Nature. 365 (6441): 82–85. Bibcode:1993Natur.365...82F. doi:10.1038/365082a0. PMID   8361546. S2CID   4332012.
• Zhang WJ, Wu JY (October 1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Molecular and Cellular Biology. 16 (10): 5400–5408. doi:10.1128/MCB.16.10.5400. PMC   231539 . PMID   8816452.
• Tronchère H, Wang J, Fu XD (July 1997). "A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA". Nature. 388 (6640): 397–400. Bibcode:1997Natur.388..397T. doi: 10.1038/41137 . PMID   9237760. S2CID   4386808.
• Sureau A, Soret J, Guyon C, Gaillard C, Dumon S, Keller M, et al. (November 1997). "Characterization of multiple alternative RNAs resulting from antisense transcription of the PR264/SC35 splicing factor gene". Nucleic Acids Research. 25 (22): 4513–4522. doi:10.1093/nar/25.22.4513. PMC   147067 . PMID   9358160.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Zhang WJ, Wu JY (February 1998). "Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing". Molecular and Cellular Biology. 18 (2): 676–684. doi:10.1128/mcb.18.2.676. PMC   108778 . PMID   9447963.
• Imai Y, Matsuo N, Ogawa S, Tohyama M, Takagi T (January 1998). "Cloning of a gene, YT521, for a novel RNA splicing-related protein induced by hypoxia/reoxygenation". Brain Research. Molecular Brain Research. 53 (1–2): 33–40. doi:10.1016/S0169-328X(97)00262-3. PMID   9473574.
• Parfenov VN, Davis DS, Pochukalina GN, Kostyuchek D, Murti KG (April 1998). "Dynamics of distribution of splicing components relative to the transcriptional state of human oocytes from antral follicles". Journal of Cellular Biochemistry. 69 (1): 72–80. doi:10.1002/(SICI)1097-4644(19980401)69:1<72::AID-JCB8>3.0.CO;2-S. PMID   9513048. S2CID   29105448.

External links

• Overview of all the structural information available in the PDB for UniProt : Q01130 (Serine/arginine-rich splicing factor 2) at the PDBe-KB .