SRSF2

Last updated
SRSF2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SRSF2 , PR264, SC-35, SC35, SFRS2, SFRS2A, SRp30b, serine/arginine-rich splicing factor 2, serine and arginine rich splicing factor 2
External IDs OMIM: 600813; MGI: 98284; HomoloGene: 37721; GeneCards: SRSF2; OMA:SRSF2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001195427
NM_003016

NM_011358

RefSeq (protein)

NP_001182356
NP_003007

NP_035488

Location (UCSC) Chr 17: 76.73 – 76.74 Mb Chr 11: 116.85 – 116.85 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serine/arginine-rich splicing factor 2 is a protein that in humans is encoded by the SRSF2 gene. [5] [6] [7] MDS-associated splicing factor SRSF2 affects the expression of Class III and Class IV isoforms and perturbs granulopoiesis and SRSF2 P95H promotes Class IV splicing by binding to key ESE sequences in CSF3R exon 17, and that SRSF2, when mutated, contributes to dysgranulopoiesis. [8]

Contents

Interactions

SFRS2 has been shown to interact with CDC5L [9] and ASF/SF2. [10]

Related Research Articles

<span class="mw-page-title-main">U2AF2</span> Protein-coding gene in the species Homo sapiens

Splicing factor U2AF 65 kDa subunit is a protein that in humans is encoded by the U2AF2 gene.

snRNP70 Protein-coding gene in the species Homo sapiens

snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein that in humans is encoded by the SNRNP70 gene. snRNP70 is a small nuclear ribonucleoprotein that associates with U1 spliceosomal RNA, forming the U1snRNP a core component of the spliceosome. The U1-70K protein and other components of the spliceosome complex form detergent-insoluble aggregates in both sporadic and familial human cases of Alzheimer's disease. U1-70K co-localizes with Tau in neurofibrillary tangles in Alzheimer's disease.

<span class="mw-page-title-main">Eukaryotic translation initiation factor 4 gamma 1</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 4 gamma 1 is a protein that in humans is encoded by the EIF4G1 gene.

<span class="mw-page-title-main">U2 small nuclear RNA auxiliary factor 1</span> Protein-coding gene in the species Homo sapiens

Splicing factor U2AF 35 kDa subunit is a protein that in humans is encoded by the U2AF1 gene.

<span class="mw-page-title-main">SRPK1</span> Protein-coding gene in the species Homo sapiens

Serine/arginine-Rich Splicing Factor (SRSF) protein kinase-1 SRPK1 is an enzyme that in humans is encoded by the SRPK1 gene.

<span class="mw-page-title-main">RNPS1</span> Protein-coding gene in the species Homo sapiens

RNA-binding protein with serine-rich domain 1 is a protein that in humans is encoded by the RNPS1 gene.

<span class="mw-page-title-main">SFRS3</span> Protein-coding gene in the species Homo sapiens

Splicing factor, arginine/serine-rich 3 is a protein that in humans is encoded by the SFRS3 gene.

<span class="mw-page-title-main">SF3B1</span> Protein-coding gene in humans

Splicing factor 3B subunit 1 is a protein that in humans is encoded by the SF3B1 gene.

<span class="mw-page-title-main">SFRS6</span> Protein-coding gene in the species Homo sapiens

Splicing factor, arginine/serine-rich 6 is a protein that in humans is encoded by the SFRS6 gene.

<span class="mw-page-title-main">SFRS7</span> Protein-coding gene in the species Homo sapiens

Serine/arginine-rich splicing factor 7 (SRSF7) also known as splicing factor, arginine/serine-rich 7 (SFRS7) or splicing factor 9G8 is a protein that in humans is encoded by the SRSF7 gene.

<span class="mw-page-title-main">SFRS9</span> Protein-coding gene in the species Homo sapiens

Splicing factor, arginine/serine-rich 9, also known as SFRS9, is a human gene encoding an SR protein involved in splice site selection in alternative splicing.

<span class="mw-page-title-main">SFRS5</span> Protein-coding gene in the species Homo sapiens

Splicing factor, arginine/serine-rich 5 is a protein that in humans is encoded by the SFRS5 gene.

<span class="mw-page-title-main">CLK1</span> Protein-coding gene in the species Homo sapiens

Dual specificity protein kinase CLK1 is an enzyme that in humans is encoded by the CLK1 gene.

<span class="mw-page-title-main">FUSIP1</span> Protein-coding gene in the species Homo sapiens

FUS-interacting serine-arginine-rich protein 1 is a protein that in humans is encoded by the SFRS13A gene.

<span class="mw-page-title-main">SFRS4</span> Protein-coding gene in the species Homo sapiens

Splicing factor, arginine/serine-rich 4 is a protein that in humans is encoded by the SFRS4 gene.

<span class="mw-page-title-main">TARBP2</span> Protein

RISC-loading complex subunit TARBP2 is a protein that in humans is encoded by the TARBP2 gene.

<span class="mw-page-title-main">DDX6</span> Protein-coding gene in the species Homo sapiens

Probable ATP-dependent RNA helicase DDX6 is an enzyme that in humans is encoded by the DDX6 gene.

<span class="mw-page-title-main">SFRS2IP</span> Protein-coding gene in the species Homo sapiens

SFRS2-interacting protein is a protein that in humans is encoded by the SFRS2IP gene.

<span class="mw-page-title-main">SFRS11</span> Protein-coding gene in the species Homo sapiens

Splicing factor, arginine/serine-rich 11 is a protein that in humans is encoded by the SFRS11 gene.

<span class="mw-page-title-main">Serine/arginine-rich splicing factor 1</span> Protein-coding gene in the species Homo sapiens

Serine/arginine-rich splicing factor 1 (SRSF1) also known as alternative splicing factor 1 (ASF1), pre-mRNA-splicing factor SF2 (SF2) or ASF1/SF2 is a protein that in humans is encoded by the SRSF1 gene. ASF/SF2 is an essential sequence specific splicing factor involved in pre-mRNA splicing. SRSF1 is the gene that codes for ASF/SF2 and is found on chromosome 17. The resulting splicing factor is a protein of approximately 33 kDa. ASF/SF2 is necessary for all splicing reactions to occur, and influences splice site selection in a concentration-dependent manner, resulting in alternative splicing. In addition to being involved in the splicing process, ASF/SF2 also mediates post-splicing activities, such as mRNA nuclear export and translation.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000161547 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034120 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bermingham JR, Arden KC, Naumova AK, Sapienza C, Viars CS, Fu XD, et al. (September 1995). "Chromosomal localization of mouse and human genes encoding the splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2)". Genomics. 29 (1): 70–79. doi: 10.1006/geno.1995.1216 . PMID   8530103.
  6. Fu XD, Maniatis T (April 1992). "Isolation of a complementary DNA that encodes the mammalian splicing factor SC35". Science. 256 (5056): 535–538. Bibcode:1992Sci...256..535F. doi:10.1126/science.1373910. PMID   1373910.
  7. "Entrez Gene: SFRS2 splicing factor, arginine/serine-rich 2".
  8. Wang BA, Mehta HM, Penumutchu SR, Tolbert BS, Cheng C, Kimmel M, et al. (October 2022). "Alternatively spliced CSF3R isoforms in SRSF2 P95H mutated myeloid neoplasms". Leukemia. 36 (10): 2499–2508. doi:10.1038/s41375-022-01672-4. PMID   35941213. S2CID   251408524.
  9. Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–6581. doi:10.1093/emboj/19.23.6569. PMC   305846 . PMID   11101529.
  10. Zhang WJ, Wu JY (October 1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Molecular and Cellular Biology. 16 (10): 5400–5408. doi:10.1128/MCB.16.10.5400. PMC   231539 . PMID   8816452.

Further reading