Mouse Genome Informatics

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Mouse Genome Informatics (MGI) is a free, online database and bioinformatics resource hosted by The Jackson Laboratory, with funding by the National Human Genome Research Institute (NHGRI), the National Cancer Institute (NCI), and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). [1] MGI provides access to data on the genetics, genomics and biology of the laboratory mouse to facilitate the study of human health and disease. [2] [3] The database integrates multiple projects, with the two largest contributions coming from the Mouse Genome Database and Mouse Gene Expression Database (GXD). [4] As of 2018, MGI contains data curated from over 230,000 publications. [5]

Contents

The MGI resource was first published online in 1994 [5] and is a collection of data, tools, and analyses created and tailored for use in the laboratory mouse, a widely used model organism. It is "the authoritative source of official names for mouse genes, alleles, and strains", which follow the guidelines established by the International Committee on Standardized Genetic Nomenclature for Mice. [6] The history and focus of Jackson Laboratory research and production facilities generates tremendous knowledge and depth which researchers can mine to advance their research. A dedicated community of mouse researchers, worldwide enhances and contributes to the knowledge as well. This is an indispensable tool for any researcher using the mouse as a model organism for their research, and for researchers interested in genes that share homology with the mouse genes. Various mouse research support resources including animal collections and free colony management software are also available at the MGI site. [7]

Mouse Genome Database

The Mouse Genome Database collects and curates comprehensive phenotype and functional annotations for mouse genes and alleles. [8] This is an NHGRI-funded project which contributes to the Mouse Genome Informatics database.

Mouse gene expression database

The Gene Expression Database is a community resource of mouse developmental expression information. [9]

History

The Mouse Genome Informatics homepage as it appeared in 1994 MGI homepage 1994.jpg
The Mouse Genome Informatics homepage as it appeared in 1994

MGI evolved from a project funded by the National Center for Human Genome Research in 1989 to combine the databases of several Jackson Laboratory scientists and create a tool for visualizing data on the mouse genome. [10] The result of that project, led by Joseph H. Nadeau, Larry E. Mobraaten, and Janan T. Eppig, was called the "Encyclopedia of the Mouse Genome" and distributed via floppy disk semi-annually to around 300 scientists around the world. [10] In 1992, that group joined with the team responsible for developing the "Genomic Database for Mouse", led by Muriel T. Davisson and Thomas H. Roderick, to start the "Mouse Genome Informatics" project. [10] That project resulted in the first online release of the "Mouse Genome Database" in 1994. [10]


See also

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References

  1. ↑ "MGI-MGI Current Funding Support". jax.org. Retrieved 2 June 2015.
  2. ↑ Shaw D (May 2004). "Searching the Mouse Genome Informatics (MGI) resources for information on mouse biology from genotype to phenotype". Current Protocols in Bioinformatics. Chapter 1: Unit 1.7. doi:10.1002/0471250953.bi0107s05. ISBN   0471250953. PMC   5147750 . PMID   18428715.
  3. ↑ Qi D, Blake JA, Kadin JA, Richardson JE, Ringwald M, Eppig JT, Bult CJ (8–11 August 2005). Data integration in the mouse genome informatics (MGI) database. Computational Systems Bioinformatics Conference, 2005. Workshops and Poster Abstracts. IEEE. pp. 37–8. doi:10.1109/CSBW.2005.48. ISBN   0-7695-2442-7.
  4. ↑ "MGI-About the Mouse Genome Informatics database resource". jax.org. Retrieved 2 June 2015.
  5. 1 2 Law, M; Shaw, DR (2018). Mouse Genome Informatics (MGI) Is the International Resource for Information on the Laboratory Mouse. Methods in Molecular Biology. Vol. 1757. pp. 141–161. doi:10.1007/978-1-4939-7737-6_7. ISBN   978-1-4939-7736-9. PMID   29761459.
  6. ↑ Mouse Nomenclature Home Page , retrieved 28 August 2016
  7. ↑ Ivica Letunic. "OpenHelix: Mouse Genome Informatics (MGI)". openhelix.com. Archived from the original on 26 December 2017. Retrieved 2 June 2015.
  8. ↑ Blake, Judith A.; Bult, Carol J.; Kadin, James A.; Richardson, Joel E.; Eppig, Janan T.; The Mouse Genome Database Group (Jan 2011). "The Mouse Genome Database (MGD): premier model organism resource for mammalian genomics and genetics". Nucleic Acids Res. England. 39 (Database issue): D842-8. doi:10.1093/nar/gkq1008. PMC   3013640 . PMID   21051359.
  9. ↑ Finger, Jacqueline H; Smith Constance M; Hayamizu Terry F; McCright Ingeborg J; Eppig Janan T; Kadin James A; Richardson Joel E; Ringwald Martin (Jan 2011). "The mouse Gene Expression Database (GXD): 2011 update". Nucleic Acids Res. England. 39 (Database issue): D835-41. doi:10.1093/nar/gkq1132. PMC   3013713 . PMID   21062809.
  10. 1 2 3 4 Eppig JT, Richardson JE, Kadin JA, Ringwald M, Blake JA, Bult CJ (August 2015). "Mouse Genome Informatics (MGI): reflecting on 25 years". Mamm Genome. 26 (7–8): 272–84. doi:10.1007/s00335-015-9589-4. PMC   4534491 . PMID   26238262.
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