Sarcosine/dimethylglycine N-methyltransferase

Sarcosine/dimethylglycine N-methyltransferase
Identifiers
EC no.	2.1.1.157
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Sarcosine/dimethylglycine N-methyltransferase (EC 2.1.1.157, ApDMT, sarcosine-dimethylglycine methyltransferase, SDMT, sarcosine dimethylglycine N-methyltransferase, S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:sarcosine(or N,N-dimethylglycine) N-methyltransferase (N,N-dimethylglycine(or betaine)-forming). ^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

2 S-adenosyl-L-methionine + sarcosine ${\displaystyle \rightleftharpoons }$ 2 S-adenosyl-L-homocysteine + betaine (overall reaction)

(1a) S-adenosyl-L-methionine + sarcosine ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + N,N-dimethylglycine

(1b) S-adenosyl-L-methionine + N,N-dimethylglycine ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + betaine

This enzyme participates in biosynthesis of betaine from glycine in cyanobacterium Aphanocthece halophytica .

References

1. Nyyssola A, Kerovuo J, Kaukinen P, von Weymarn N, Reinikainen T (July 2000). "Extreme halophiles synthesize betaine from glycine by methylation". The Journal of Biological Chemistry. 275 (29): 22196–201. doi: 10.1074/jbc.M910111199 . PMID   10896953.
2. Nyyssölä A, Reinikainen T, Leisola M (May 2001). "Characterization of glycine sarcosine N-methyltransferase and sarcosine dimethylglycine N-methyltransferase". Applied and Environmental Microbiology. 67 (5): 2044–50. doi:10.1128/AEM.67.5.2044-2050.2001. PMC   92834 . PMID   11319079.
3. Waditee R, Tanaka Y, Aoki K, Hibino T, Jikuya H, Takano J, Takabe T, Takabe T (February 2003). "Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica". The Journal of Biological Chemistry. 278 (7): 4932–42. doi: 10.1074/jbc.M210970200 . PMID   12466265.

External links

• Sarcosine/dimethylglycine+N-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)