Small nucleolar RNA Z13/snr52

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Small nucleolar RNA Z13/snr52
RF00335.jpg
Predicted secondary structure and sequence conservation of snoZ13_snr52
Identifiers
SymbolsnoZ13_snr52
Rfam RF00335
Other data
RNA type Gene; snRNA; snoRNA; CD-box
Domain(s) Eukaryota
GO GO:0006396 GO:0005730
SO SO:0000593
PDB structures PDBe

In molecular biology, Small nucleolar RNA snR52 (homologous to Z13) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA Z13 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1]

snoRNA snR52 was initially discovered using a computational screen of the Saccharomyces cerevisiae genome; [2] subsequent work identified Z13 in Schizosaccharomyces pombe. Further experiments have shown that snR52 is transcribed by RNA polymerase III. [3] [4]

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Small nucleolar RNA snR64

In molecular biology, snR64 is an RNA molecule belonging to the C/D class of small nucleolar RNA (snoRNA), which contain the C (UGAUGA) and D (CUGA) box motifs. Similar to most members of the box C/D family, snR64 is conjectured to help direct site-specific 2'-O-methylation of substrate RNAs.

Small nucleolar RNA snR66

snoRNA snR66 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA snR66 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. snoRNA snR66 was initially discovered using a computational screen of the Saccharomyces cerevisiae genome.

Small nucleolar RNA snR69

In molecular biology, snoRNA snR69 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA snR69 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. snoRNA snR69 was initially discovered using a computational screen of the Saccharomyces cerevisiae genome.

Small nucleolar RNA snR71

In molecular biology, snoRNA snR71 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA snR71 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. snoRNA snR71 was initially discovered using a computational screen of the Saccharomyces cerevisiae genome.

The small nucleolar RNAs (snoRNAs) represent an abundant group of small non-coding RNAs (ncRNAs) in eukaryotes. With the exception of RNase MRP, all the snoRNAs fall into two major families, box C/D and box H/ACA snoRNAs, on the basis of common sequence motifs and structural features. They can be divided into guide and orphan snoRNAs according to the presence or absence of antisense sequence to rRNAs or snRNAs. Recently, thousands of novel snoRNAs were identified from small RNA sequencing datasets in human, mouse, chicken, Ciona intestinalis, Drosophila melanogaster, Caenhorhabditis elegans and Arabidopsis thaliana using snoSeekerNGS program.

References

  1. Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology . 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC   134041 . PMID   12215523.
  2. Lowe, T. M.; Eddy, S. R. (February 1999). "A Computational Screen for Methylation Guide snoRNAs in Yeast". Science . 283 (5405): 1168–1171. Bibcode:1999Sci...283.1168L. doi:10.1126/science.283.5405.1168. PMID   10024243.
  3. Harismendy O, Gendrel CG, Soularue P, et al. (2003). "Genome-wide location of yeast RNA polymerase III transcription machinery". EMBO J. 22 (18): 4738–47. doi:10.1093/emboj/cdg466. PMC   212732 . PMID   12970186.
  4. Marck C, Kachouri-Lafond R, Lafontaine I, Westhof E, Dujon B, Grosjean H (2006). "The RNA polymerase III-dependent family of genes in hemiascomycetes: comparative RNomics, decoding strategies, transcription and evolutionary implications". Nucleic Acids Res. 34 (6): 1816–35. doi:10.1093/nar/gkl085. PMC   1447645 . PMID   16600899.