Small nucleolar RNA snR60/Z15/Z230/Z193/J17

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Small nucleolar RNA snR60/Z15/Z230/Z193/J17
RF00309.jpg
Predicted secondary structure and sequence conservation of snosnR60_Z15
Identifiers
SymbolsnosnR60_Z15
Alt. SymbolssnoZ193
Rfam RF00309
Other data
RNA type Gene; snRNA; snoRNA; CD-box
Domain(s) Eukaryota
GO GO:0006396 GO:0005730
SO SO:0000593
PDB structures PDBe

In molecular biology, snoRNA snR60 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA snR60 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] snoRNA snR60 was initially discovered using a computational screen of the Saccharomyces cerevisiae genome, [2] subsequent experimental screens discovered plant homologues Z15, Z230, Z193 and J17 [3] and human U80/SNORD80.

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References

  1. Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (October 2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Molecular and Cellular Biology. 22 (19): 6663–8. doi:10.1128/MCB.22.19.6663-6668.2002. PMC   134041 . PMID   12215523.
  2. Lowe TM, Eddy SR (February 1999). "A computational screen for methylation guide snoRNAs in yeast". Science. 283 (5405): 1168–71. Bibcode:1999Sci...283.1168L. doi:10.1126/science.283.5405.1168. PMID   10024243.
  3. Chen CL, Liang D, Zhou H, Zhuo M, Chen YQ, Qu LH (May 2003). "The high diversity of snoRNAs in plants: identification and comparative study of 120 snoRNA genes from Oryza sativa". Nucleic Acids Research. 31 (10): 2601–13. doi:10.1093/nar/gkg373. PMC   156054 . PMID   12736310.