Small nucleolar RNA snoR639/H1

Last updated
Small nucleolar RNA snoR639/H1
RF00291.jpg
Identifiers
SymbolsnoR639
Rfam RF00291
Other data
RNA type Gene; snRNA; snoRNA; HACA-box
Domain(s) Eukaryota
GO GO:0006396 GO:0005730
SO SO:0001263
PDB structures PDBe

In molecular biology, Small nucleolar RNA snoR639 (also known as snoH1) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'.

snoR639 was originally identified in a study of Drosophila melanogaster minifly (mfl) gene; snoR639 resides in the intron of this gene. [1] It was later rediscovered by a large-scale RNomics effort. [2] snoR639 belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure, has the conserved H/ACA-box motifs and is found associated with GAR1 protein.

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References

  1. Giordano E, Peluso I, Senger S, Furia M (March 1999). "minifly, a Drosophila gene required for ribosome biogenesis". The Journal of Cell Biology. 144 (6): 1123–33. doi:10.1083/jcb.144.6.1123. PMC   2150573 . PMID   10087258.
  2. Yuan G, Klämbt C, Bachellerie JP, Brosius J, Hüttenhofer A (May 2003). "RNomics in Drosophila melanogaster: identification of 66 candidates for novel non-messenger RNAs". Nucleic Acids Research. 31 (10): 2495–507. doi:10.1093/nar/gkg361. PMC   156043 . PMID   12736298.