Spla/ryanodine receptor domain and socs box containing 3

SPSB3
Identifiers
Aliases	SPSB3 , C16orf31, SSB3, Spla/ryanodine receptor domain and socs box containing 3
External IDs	OMIM: 611659 MGI: 1891471 HomoloGene: 12322 GeneCards: SPSB3
Gene location (Human)
Chr.	Chromosome 16 (human)
End	1,793,700 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	25,111,126 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; gastric mucosa; ; endothelial cell; ; right lobe of liver; ; skin of abdomen; ; gastrocnemius muscle; ; right adrenal gland; ; body of pancreas; ; amniotic fluid; ; body of stomach;
	Top expressed in
	spermatocyte; ; saccule; ; spermatid; ; otic placode; ; lip; ; seminiferous tubule; ; esophagus; ; thymus; ; temporal muscle; ; sternocleidomastoid muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; ubiquitin-protein transferase activity ;
Cellular component	cytosol ; SCF ubiquitin ligase complex ;
Biological process	protein ubiquitination ; post-translational protein modification ; ubiquitin-dependent protein catabolic process ; proteasome-mediated ubiquitin-dependent protein catabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	90864
	79043
	ENSG00000162032
	ENSMUSG00000024160
	Q6PJ21
	Q571F5
	NM_080861 ; NM_001324081
NM_001163750 ; NM_001163751 ; NM_027141 ; NM_001374602 ; NM_001400229 ;
	NM_001400231 ; NM_001400234 ; NM_001400235 ; NM_001400236 ; NM_001400237 ; NM_001400238 ; NM_001400240 Contents References ; External links ; Further reading ;
	NP_001311010 ; NP_543137
NP_001157222 ; NP_001157223 ; NP_081417 ; NP_001361531 ; NP_001387158 ;
	NP_001387160 ; NP_001387163 ; NP_001387164 ; NP_001387165 ; NP_001387166 ; NP_001387167 ; NP_001387169
	Wikidata
View/Edit Human	View/Edit Mouse

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

SPRY domain
SPRY domain
Identifiers
Symbol	SPRY
Pfam	PF00622
InterPro	IPR003877
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Last updated February 24, 2024

SplA/ryanodine receptor domain and SOCS box containing 3 is a protein that in humans is encoded by the SPSB3 gene.^[5]

Related Research Articles

Ryanodine receptor 2 (RYR2) is one of a class of ryanodine receptors and a protein found primarily in cardiac muscle. In humans, it is encoded by the RYR2 gene. In the process of cardiac calcium-induced calcium release, RYR2 is the major mediator for sarcoplasmic release of stored calcium ions.

Rap guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the RAPGEF1 gene.

Frizzled-6(Fz-6) is a protein that in humans is encoded by the FZD6 gene.

Suppressor of cytokine signaling 1 is a protein that in humans is encoded by the SOCS1 gene. SOCS1 orthologs have been identified in several mammals for which complete genome data are available.

Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene.

Homer protein homolog 1 or Homer1 is a neuronal protein that in humans is encoded by the HOMER1 gene. Other names are Vesl and PSD-Zip45.

Sorcin is a protein that in humans is encoded by the SRI gene.

Cytokine-inducible SH2-containing protein is a protein that in humans is encoded by the CISH gene. CISH orthologs have been identified in most mammals with sequenced genomes. CISH controls T cell receptor (TCR) signaling, and variations of CISH with certain SNPs are associated with susceptibility to bacteremia, tuberculosis and malaria.

Peptidyl-prolyl cis-trans isomerase FKBP1B is an enzyme that in humans is encoded by the FKBP1B gene.

Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like protein, is a protein that in humans is encoded by the MST1 gene.

Triadin, also known as TRDN, is a human gene associated with the release of calcium ions from the sarcoplasmic reticulum triggering muscular contraction through calcium-induced calcium release. Triadin is a multiprotein family, arising from different processing of the TRDN gene on chromosome 6. It is a transmembrane protein on the sarcoplasmic reticulum due to a well defined hydrophobic section and it forms a quaternary complex with the cardiac ryanodine receptor (RYR2), calsequestrin (CASQ2) and junctin proteins. The luminal (inner compartment of the sarcoplasmic reticulum) section of Triadin has areas of highly charged amino acid residues that act as luminal Ca²⁺ receptors. Triadin is also able to sense luminal Ca²⁺ concentrations by mediating interactions between RYR2 and CASQ2. Triadin has several different forms; Trisk 95 and Trisk 51, which are expressed in skeletal muscle, and Trisk 32 (CT1), which is mainly expressed in cardiac muscle.

SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene.

Suppressor of cytokine signaling 7 is a protein that in humans is encoded by the SOCS7 gene.

Receptor-interacting serine/threonine-protein kinase 3 is an enzyme that is encoded by the RIPK3 gene in humans.

Glucocorticoid receptor DNA-binding factor 1 is a protein that in humans is encoded by the GRLF1 gene.

Suppressor of cytokine signaling 5 is a protein that in humans is encoded by the SOCS5 gene.

Homer protein homolog 3 is a protein that in humans is encoded by the HOMER3 gene.

SPRY domain-containing SOCS box protein 1 is a protein that in humans is encoded by the SPSB1 gene.

Ryanodine receptor 1 (RYR-1) also known as skeletal muscle calcium release channel or skeletal muscle-type ryanodine receptor is one of a class of ryanodine receptors and a protein found primarily in skeletal muscle. In humans, it is encoded by the RYR1 gene.

Ankyrin repeat and SOCS box protein 6 is a protein that in humans is encoded by the ASB6 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000162032 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024160 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: SplA/ryanodine receptor domain and SOCS box containing 3".

External links

Eukaryotic Linear Motif resource motif class LIG_SPRY_1

Nishiya T, Matsumoto K, Maekawa S, Kajita E, Horinouchi T, Fujimuro M, Ogasawara K, Uehara T, Miwa S (March 2011). "Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins". The Journal of Biological Chemistry. 286 (11): 9009–19. doi: 10.1074/jbc.M110.190678 . PMC 3058989 . PMID 21199876.
Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (May 2002). "The SOCS box: a tale of destruction and degradation". Trends in Biochemical Sciences. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
Wang D, Li Z, Messing EM, Wu G (April 2005). "The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway". The Journal of Biological Chemistry. 280 (16): 16393–401. doi: 10.1074/jbc.M413897200 . PMID 15713673.
Naukkarinen J, Surakka I, Pietiläinen KH, Rissanen A, Salomaa V, Ripatti S, Yki-Järvinen H, van Duijn CM, Wichmann HE, Kaprio J, Taskinen MR, Peltonen L (June 2010). Gibson G (ed.). "Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes". PLOS Genetics. 6 (6): e1000976. doi: 10.1371/journal.pgen.1000976 . PMC 2880558 . PMID 20532202.
Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR (February 2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Human Molecular Genetics. 10 (4): 339–52. doi: 10.1093/hmg/10.4.339 . PMID 11157797.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000162032 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024160 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SplA/ryanodine receptor domain and SOCS box containing 3".

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Spla/ryanodine receptor domain and socs box containing 3

Contents

Related Research Articles

References

External links

Further reading