TRNA (cytidine32/guanosine34-2'-O)-methyltransferase

TRNA (cytidine32/guanosine34-2'-O)-methyltransferase
Identifiers
EC no.	2.1.1.205
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

TRNA (cytidine³²/guanosine³⁴-2'-O)-methyltransferase (EC 2.1.1.205, Trm7p) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytidine32/guanosine34-2'-O)-methyltransferase. ^[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + cytidine ³²/guanosine ³⁴ in tRNA ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + 2'-O-methylcytidine³²/2'-O-methylguanosine³⁴ in tRNA

The enzyme from Saccharomyces cerevisiae catalyses the formation of 2'-O-methylnucleotides at positions 32 and 34 of the yeast tRNAPhe and tRNATrp.

References

1. Pintard L, Lecointe F, Bujnicki JM, Bonnerot C, Grosjean H, Lapeyre B (April 2002). "Trm7p catalyses the formation of two 2'-O-methylriboses in yeast tRNA anticodon loop". The EMBO Journal. 21 (7): 1811–20. doi:10.1093/emboj/21.7.1811. PMC   125368 . PMID   11927565.

External links

• TRNA+(cytidine32/guanosine34-2'-O)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)