TRNA (cytidine32/uridine32-2'-O)-methyltransferase

TRNA (cytidine32/uridine32-2'-O)-methyltransferase
Identifiers
EC no.	2.1.1.200
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

TRNA (cytidine³²/uridine³²-2'-O)-methyltransferase (EC 2.1.1.200, YfhQ, tRNA:Cm³²/Um³² methyltransferase, TrMet(Xm³²), TrmJ) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytidine³²/uridine³²-2'-O)-methyltransferase. ^[1] This enzyme catalyses the following chemical reaction

(1) S-adenosyl-L-methionine + cytidine ³² in tRNA ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + 2'-O-methylcytidine³² in tRNA

(2) S-adenosyl-L-methionine + uridine ³² in tRNA ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + 2'-O-methyluridine32 in tRNA

In Escherichia coli YfhQ is the only methyltransferase responsible for the formation of 2'-O-methylcytidine32 in tRNA.

References

1. Purta E, van Vliet F, Tkaczuk KL, Dunin-Horkawicz S, Mori H, Droogmans L, Bujnicki JM (July 2006). "The yfhQ gene of Escherichia coli encodes a tRNA:Cm32/Um32 methyltransferase". BMC Molecular Biology. 7: 23. doi: 10.1186/1471-2199-7-23 . PMC   1569432 . PMID   16848900.

External links

• TRNA+(cytidine32/uridine32-2'-O)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)