Trimethoprim/polymyxin B

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Trimethoprim/polymyxin B
Combination of
Polymyxin B Cell envelope antibiotic
Trimethoprim Nucleic acid inhibitor antibiotic
Clinical data
Trade names Polytrim
Routes of
administration 		Topical eye drops
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
KEGG
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Polymyxin B/trimethoprim, sold under the brand name Polytrim is an antimicrobial solution for topical ophthalmic use in the treatment of acute bacterial conjunctivitis and blepharoconjunctivitis. [1]

In 2022, it was the 252nd most commonly prescribed medication in the United States, with more than 1 million prescriptions. [2] [3]

Medical uses

Polymyxin B/trimethoprim is indicated in the treatment of surface ocular bacterial infections, [4] including acute bacterial conjunctivitis, and blepharoconjunctivitis, caused by susceptible strains of the following microorganisms: Staphylococcus aureus , Staphylococcus epidermidis , Streptococcus pneumoniae , Streptococcus viridans , Haemophilus influenzae , and Pseudomonas aeruginosa . [1]

References

  1. 1 2 3 "Polytrim (polymyxin B sulfate and trimethoprim ophthalmic solution, USP) Sterile". DailyMed. Retrieved 6 December 2024.
  2. ↑ "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
  3. ↑ "Polymyxin B; Trimethoprim Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.
  4. ↑ Yolton DP (1992). "New antibacterial drugs for topical ophthalmic use". Optometry Clinics. 2 (4): 59–72. PMID   1286241.


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