Ultrasound research interface

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An ultrasound research interface (URI) is a software tool loaded onto a diagnostic clinical ultrasound device which provides functionality beyond typical clinical modes of operation.

Ultrasound vibrations with frequencies above the human hearing range

Ultrasound is sound waves with frequencies higher than the upper audible limit of human hearing. Ultrasound is not different from "normal" (audible) sound in its physical properties, except that humans cannot hear it. This limit varies from person to person and is approximately 20 kilohertz in healthy young adults. Ultrasound devices operate with frequencies from 20 kHz up to several gigahertz.

Contents

A normal clinical ultrasound user only has access to the ultrasound data in its final processed form, typically a B-Mode image, in DICOM format. For reasons of device usability they also have limited access to the processing parameters that can be modified. [1] [2] [3] [4]

Digital Imaging and Communications in Medicine (DICOM) is the standard for the communication and management of medical imaging information and related data. DICOM is most commonly used for storing and transmitting medical images enabling the integration of medical imaging devices such as scanners, servers, workstations, printers, network hardware, and picture archiving and communication systems (PACS) from multiple manufacturers. It has been widely adopted by hospitals, and is making inroads into smaller applications like dentists' and doctors' offices.

A URI allows a researcher to achieve different results by either acquiring the image at various intervals through the processing chain, or changing the processing parameters.

Typical B-mode receive processing chain

A typical digital ultrasound processing chain for B-Mode imaging may look as follows:

A variable-gain or voltage-controlled amplifier is an electronic amplifier that varies its gain depending on a control voltage.

Analog-to-digital converter system that converts an analog signal, such as a sound picked up by a microphone or light entering a digital camera, into a digital signal; device converting a physical quantity to a digital number

In electronics, an analog-to-digital converter is a system that converts an analog signal, such as a sound picked up by a microphone or light entering a digital camera, into a digital signal. An ADC may also provide an isolated measurement such as an electronic device that converts an input analog voltage or current to a digital number representing the magnitude of the voltage or current. Typically the digital output is a two's complement binary number that is proportional to the input, but there are other possibilities.

Radio frequency (RF) is the oscillation rate of an alternating electric current or voltage or of a magnetic, electric or electromagnetic field or mechanical system in the frequency range from around twenty thousand times per second to around three hundred billion times per second. This is roughly between the upper limit of audio frequencies and the lower limit of infrared frequencies; these are the frequencies at which energy from an oscillating current can radiate off a conductor into space as radio waves. Different sources specify different upper and lower bounds for the frequency range.

Multiple signals processed in this way are lined up together and interpolated and rasterized into a readable image.

Data access

A URI may provide data access at many different stages of the processing chain, these include:

Where many diagnostic ultrasound devices have Doppler imaging modes for measuring blood flow, the URI may also provide access to Doppler related signal data, which can include:

Fast Fourier transform O(n logn) divide and conquer algorithm to calculate the discrete Fourier transforms

A fast Fourier transform (FFT) is an algorithm that computes the discrete Fourier transform (DFT) of a sequence, or its inverse (IDFT). Fourier analysis converts a signal from its original domain to a representation in the frequency domain and vice versa. The DFT is obtained by decomposing a sequence of values into components of different frequencies. This operation is useful in many fields, but computing it directly from the definition is often too slow to be practical. An FFT rapidly computes such transformations by factorizing the DFT matrix into a product of sparse factors. As a result, it manages to reduce the complexity of computing the DFT from , which arises if one simply applies the definition of DFT, to , where is the data size. The difference in speed can be enormous, especially for long data sets where N may be in the thousands or millions. In the presence of round-off error, many FFT algorithms are much more accurate than evaluating the DFT definition directly. There are many different FFT algorithms based on a wide range of published theories, from simple complex-number arithmetic to group theory and number theory.

Tools

A URI may include many different tools for enabling the researcher to make better use of the device and the data captured, some of these tools include:

MATLAB multi-paradigm numerical computing environment

MATLAB is a multi-paradigm numerical computing environment and proprietary programming language developed by MathWorks. MATLAB allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages, including C, C++, C#, Java, Fortran and Python.

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In electronics and telecommunications, modulation is the process of varying one or more properties of a periodic waveform, called the carrier signal, with a modulating signal that typically contains information to be transmitted. Most radio systems in the 20th century used frequency modulation (FM) or amplitude modulation (AM) for radio broadcast.

Microcontroller small computer on a single integrated circuit

A microcontroller is a small computer on a single integrated circuit. In modern terminology, it is similar to, but less sophisticated than, a system on a chip (SoC); an SoC may include a microcontroller as one of its components. A microcontroller contains one or more CPUs along with memory and programmable input/output peripherals. Program memory in the form of ferroelectric RAM, NOR flash or OTP ROM is also often included on chip, as well as a small amount of RAM. Microcontrollers are designed for embedded applications, in contrast to the microprocessors used in personal computers or other general purpose applications consisting of various discrete chips.

Digital audio technology that records, stores, and reproduces sound

Digital audio is sound that has been recorded in, or converted into, digital form. In digital audio, the sound wave of the audio signal is encoded as numerical samples in continuous sequence. For example, in CD audio, samples are taken 44100 times per second each with 16 bit sample depth. Digital audio is also the name for the entire technology of sound recording and reproduction using audio signals that have been encoded in digital form. Following significant advances in digital audio technology during the 1970s, it gradually replaced analog audio technology in many areas of audio engineering and telecommunications in the 1990s and 2000s.

Digital Visual Interface standard for transmitting digital video to a display (such as a monitor)

Digital Visual Interface (DVI) is a video display interface developed by the Digital Display Working Group (DDWG). The digital interface is used to connect a video source, such as a video display controller, to a display device, such as a computer monitor. It was developed with the intention of creating an industry standard for the transfer of digital video content.

Software-defined radio radio communication system implemented in software

Software-defined radio (SDR) is a radio communication system where components that have been traditionally implemented in hardware are instead implemented by means of software on a personal computer or embedded system. While the concept of SDR is not new, the rapidly evolving capabilities of digital electronics render practical many processes which were once only theoretically possible.

Medical ultrasound diagnostic imaging technique

Medical ultrasound is a diagnostic imaging technique based on the application of ultrasound. It is used to create an image of internal body structures such as tendons, muscles, joints, blood vessels, and internal organs. Its aim is often to find a source of a disease or to exclude pathology. The practice of examining pregnant women using ultrasound is called obstetric ultrasound, and was an early development and application of clinical ultrasonography.

Data acquisition all methods of simultaneous or sequential time measurement and counting for measurable or quantifiable data and groups of contiguous data

Data acquisition is the process of sampling signals that measure real world physical conditions and converting the resulting samples into digital numeric values that can be manipulated by a computer. Data acquisition systems, abbreviated by the acronyms DAS or DAQ, typically convert analog waveforms into digital values for processing. The components of data acquisition systems include:

A satellite modem or satmodem is a modem used to establish data transfers using a communications satellite as a relay. A satellite modem's main function is to transform an input bitstream to a radio signal and vice versa.

Medical imaging technique and process of creating visual representations of the interior of a body

Medical imaging is the technique and process of creating visual representations of the interior of a body for clinical analysis and medical intervention, as well as visual representation of the function of some organs or tissues (physiology). Medical imaging seeks to reveal internal structures hidden by the skin and bones, as well as to diagnose and treat disease. Medical imaging also establishes a database of normal anatomy and physiology to make it possible to identify abnormalities. Although imaging of removed organs and tissues can be performed for medical reasons, such procedures are usually considered part of pathology instead of medical imaging.

Digital subscriber line access multiplexer Network equipment

A digital subscriber line access multiplexer is a network device, often located in telephone exchanges, that connects multiple customer digital subscriber line (DSL) interfaces to a high-speed digital communications channel using multiplexing techniques.

The Serial Peripheral Interface (SPI) is a synchronous serial communication interface specification used for short-distance communication, primarily in embedded systems. The interface was developed by Motorola in the mid-1980s and has become a de facto standard. Typical applications include Secure Digital cards and liquid crystal displays.

JTAG is an industry standard for verifying designs and testing printed circuit boards after manufacture.

Analog Devices company

Analog Devices, Inc., also known as ADI or Analog, is an American multinational semiconductor company specializing in data conversion, signal processing and power management technology, headquartered in Norwood, Massachusetts. In 2012, Analog Devices led the worldwide data converter market with a 48.5% share, according to analyst firm Databeans.

Blackfin

The Blackfin is a family of 16-/32-bit microprocessors developed, manufactured and marketed by Analog Devices. The processors have built-in, fixed-point digital signal processor (DSP) functionality supplied by 16-bit multiply–accumulates (MACs), accompanied on-chip by a microcontroller. It was designed for a unified low-power processor architecture that can run operating systems while simultaneously handling complex numeric tasks such as real-time H.264 video encoding.

In signal processing, oversampling is the process of sampling a signal at a sampling frequency significantly higher than the Nyquist rate. Theoretically, a bandwidth-limited signal can be perfectly reconstructed if sampled at the Nyquist rate or above it. The Nyquist rate is defined as twice the highest frequency component in the signal. Oversampling is capable of improving resolution, reducing noise and can be helpful in avoiding aliasing and phase distortion by relaxing anti-aliasing filter performance requirements.

Universal Software Radio Peripheral Product family of software-defined radios

Universal Software Radio Peripheral (USRP) is a range of software-defined radios designed and sold by Ettus Research and its parent company, National Instruments. Developed by a team led by Matt Ettus, the USRP product family is intended to be a comparatively inexpensive hardware platform for software radio, and is commonly used by research labs, universities, and hobbyists.

Moogerfooger

Moogerfooger is the trademark for a series of analog effects pedals manufactured by Moog Music. There are currently eight different pedals produced; however, one of these models is designed for processing control voltages rather than audio signal. A sixth model, the Analog Delay, was released in a limited edition of 1000 units and has become a collector's item.

Multiple frequency-shift keying (MFSK) is a variation of frequency-shift keying (FSK) that uses more than two frequencies. MFSK is a form of M-ary orthogonal modulation, where each symbol consists of one element from an alphabet of orthogonal waveforms. M, the size of the alphabet, is usually a power of two so that each symbol represents log2M bits.

FireWire camera the IEEE 1394 bus standard for the transmission of audio, video and control data

FireWire cameras use the IEEE 1394 bus standard for the transmission of audio, video and control data. FireWire is Apple Computer's trademark for the IEEE 1394 standard.

Atari SIO

The Serial Input/Output system, universally known as SIO, was a proprietary peripheral bus and related software protocol stacks used on the Atari 8-bit family to provide most input/output duties for those computers. Unlike most I/O systems of the era, such as RS-232, SIO included a lightweight protocol that allowed multiple devices to be attached to a single daisy-chained port that supported dozens of devices. It also supported plug-n-play operations. SIO's designer, Joe Decuir, credits his work on system as the basis of USB.

References

  1. Wilson T, Zagzebski J, Varghese T, Chen Q, Rao M. The Ultrasonix 500RP: a commercial ultrasound research interface. IEEE Trans Ultrason Ferroelectr Freq Control. 2006 Oct;53(10):1772-82.
  2. Dickie K, Leung C, Zahiri R, Pelissier L. A flexible research interface for collecting clinical ultrasound images. SPIE Multispectral Image Acquisition. 2009 Oct;7494(02)
  3. Rohling R, Fung W, Lajevardi P. PUPIL: Programmable Ultrasound Platform and Interface Library. MICCAI. 2003 Nov;(2879);424-431
  4. Shamdasani V, Bae U, Sikdar S, Yoo YM, Karadayi K, Managuli R, Kim Y. Research interface on a programmable ultrasound scanner. Ultrasonics. 2008 Jul;48(03);159-168.

Ultrasound Research Laboratories

The following non-exhaustive list of research labs are typical candidates that would use an ultrasound research interface for conducting experiments and collecting data.