2,4'-dihydroxyacetophenone dioxygenase

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2,4'-dihydroxyacetophenone dioxygenase
Identifiers
EC no. 1.13.11.41
CAS no. 105503-64-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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NCBI proteins

2,4'-dihydroxyacetophenone dioxygenase (EC 1.13.11.41) is an enzyme that catalyzes the chemical reaction

 
O2
 
2,4'-dihydroxyacetophenone dioxygenase
 
 
 
+
 

The two substrates of this enzyme are 2,4'-dihydroxyacetophenone and oxygen. Its products are 4-hydroxybenzoic acid and formic acid. [1] [2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is 2,4'-dihydroxyacetophenone oxidoreductase (C-C-bond-cleaving). This enzyme is also called (4-hydroxybenzoyl)methanol oxygenase. This enzyme participates in bisphenol a degradation. [3]

References

  1. Enzyme 1.13.11.41 at KEGG Pathway Database.
  2. Hopper, D. J. (1986). "Oxygenase properties of the (4-hydroxybenzoyl)methanol-cleavage enzyme from an Alcaligenes sp". Biochemical Journal. 239 (2): 469–472. doi:10.1042/bj2390469. PMC   1147303 . PMID   3814084.
  3. Enya, Mayu; Aoyagi, Keiko; Hishikawa, Yoshihiro; Yoshimura, Azusa; Mitsukura, Koichi; Maruyama, Kiyofumi (2012). "Molecular and Catalytic Properties of 2,4′-Dihydroxyacetophenone Dioxygenase from Burkholderia sp. AZ11". Bioscience, Biotechnology, and Biochemistry. 76 (3): 567–574. doi:10.1271/bbb.110867. PMID   22451401.