| Men's singles | |
|---|---|
| 2021 Nottingham Open | |
| Champion |  Frances Tiafoe |
| Runner-up | Denis Kudla |
| Final score | 6–1, 6–3 |
Dan Evans was the defending champion [1] but lost in the quarterfinals to Denis Kudla.
Frances Tiafoe won the title after defeating Kudla 6–1, 6–3 in the final.
Dan Evans (quarterfinals) Frances Tiafoe (champion)
Andreas Seppi (quarterfinals)
Kevin Anderson (quarterfinals) Mackenzie McDonald (first round) Denis Kudla (final)
Damir Džumhur (first round)
Kamil Majchrzak (semifinals)| Semifinals | Final | ||||||||||||
| 6 | Denis Kudla | 6 | 1 | 78 | |||||||||
| 8 | Kamil Majchrzak | 4 | 6 | 66 | |||||||||
| 6 | Denis Kudla | 1 | 3 | ||||||||||
| 2 | Frances Tiafoe | 6 | 6 | ||||||||||
| Q |  Marius Copil | 3 | 2 | ||||||||||
| 2 | Frances Tiafoe | 6 | 6 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1/WC | D Evans | 4 | 77 | 77 | |||||||||||||||||||||||
 T Kokkinakis | 6 | 61 | 65 | 1/WC | D Evans | 78 | 77 | ||||||||||||||||||||
| Q | M Ebden | 6 | 6 | Q | M Ebden | 66 | 64 | ||||||||||||||||||||
| WC | R Peniston | 4 | 4 | 1/WC | D Evans | 4 | 6 | 4 | |||||||||||||||||||
| A Bolt | 5 | 6 | 3 | 6 | D Kudla | 6 | 1 | 6 | |||||||||||||||||||
| L Broady | 7 | 3 | 6 | L Broady | 6 | 3 | 62 | ||||||||||||||||||||
 T Macháč | 3 | 6 | 4 | 6 | D Kudla | 3 | 6 | 77 | |||||||||||||||||||
| 6 | D Kudla | 6 | 4 | 6 | 6 | D Kudla | 6 | 1 | 78 | ||||||||||||||||||
| 3 | A Seppi | 77 | 6 | 8 | K Majchrzak | 4 | 6 | 66 | |||||||||||||||||||
 Zh Zhang | 64 | 2 | 3 | A Seppi | 6 | 64 | 6 | ||||||||||||||||||||
| T Fabbiano | 65 | 63 |  A Hoang | 4 | 77 | 2 | |||||||||||||||||||||
| A Hoang | 77 | 77 | 3 | A Seppi | 6 | 2 | 3 | ||||||||||||||||||||
| M Polmans | 610 | 6 | 3 | 8 | K Majchrzak | 4 | 6 | 6 | |||||||||||||||||||
| Q | A Vukic | 712 | 4 | 6 | Q | A Vukic | 7 | 610 | 4 | ||||||||||||||||||
 P Gunneswaran | 0 | 0r | 8 | K Majchrzak | 5 | 712 | 6 | ||||||||||||||||||||
| 8 | K Majchrzak | 6 | 0 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 7 | D Džumhur | 4 | 6 | 1 | |||||||||||||||||||||||
| Q | M Copil | 6 | 4 | 6 | Q | M Copil | 6 | 6 | |||||||||||||||||||
| Q |  B Gojo | 3 | 712 | 66 |  S Ofner | 4 | 4 | ||||||||||||||||||||
| S Ofner | 6 | 610 | 78 | Q | M Copil | 77 | 711 | ||||||||||||||||||||
| M Cressy | 4 | 77 | 3 | 4 | K Anderson | 64 | 69 | ||||||||||||||||||||
| L Rosol | 6 | 65 | 6 | L Rosol | 3 | 4 | |||||||||||||||||||||
| WC | J Clarke | 3 | 60 | 4 | K Anderson | 6 | 6 | ||||||||||||||||||||
| 4 | K Anderson | 6 | 77 | Q | M Copil | 3 | 2 | ||||||||||||||||||||
| 5 | M McDonald | 3 | 5 | 2 | F Tiafoe | 6 | 6 | ||||||||||||||||||||
 E Donskoy | 6 | 7 | E Donskoy | 77 | 77 | ||||||||||||||||||||||
| B Nakashima | 6 | 6 | B Nakashima | 63 | 62 | ||||||||||||||||||||||
 M Vilella Martínez | 3 | 2 | E Donskoy | 64 | 6 | 3 | |||||||||||||||||||||
| F Gaio | 2 | 3 | 2 | F Tiafoe | 77 | 2 | 6 | ||||||||||||||||||||
 I Marchenko | 6 | 6 | I Marchenko | 5 | 65 | ||||||||||||||||||||||
 M-A Hüsler | 3 | 4 | 2 | F Tiafoe | 7 | 77 | |||||||||||||||||||||
| 2 | F Tiafoe | 6 | 6 | ||||||||||||||||||||||||
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