| Doubles | |
|---|---|
| 2021 Orlando Open | |
| Champions |  Mitchell Krueger Jack Sock |
| Runners-up | Christian Harrison Dennis Novikov |
| Score | 4–6, 7–5, [13–11] |
Andrey Golubev and Aleksandr Nedovyesov were the defending champions [1] but chose not to defend their title.
Mitchell Krueger and Jack Sock won the title after defeating Christian Harrison and Dennis Novikov 4–6, 7–5, [13–11] in the final.
Miguel Ángel Reyes-Varela / 
Fernando Romboli (first round) Evan King / Hunter Reese (first round) Nathan Pasha / Max Schnur (first round)
Sriram Balaji / Jeevan Nedunchezhiyan (first round)| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 | MÁ Reyes-Varela F Romboli | 2 | 7 | [6] | |||||||||||||||||||||||
| WC | C Harrison D Novikov | 6 | 5 | [10] | WC | C Harrison D Novikov | w/o | ||||||||||||||||||||
| D Kudla T-S Kwiatkowski | 65 | 2 | PR | Y Bhambri  M Ebden | |||||||||||||||||||||||
| PR | Y Bhambri M Ebden | 77 | 6 | WC | C Harrison D Novikov | 6 | 6 | ||||||||||||||||||||
| 3 | N Pasha M Schnur | 4 | 2 | JC Aragone  LD Martínez | 2 | 3 | |||||||||||||||||||||
 J de Jong S Verbeek | 6 | 6 | J de Jong S Verbeek | 6 | 4 | [8] | |||||||||||||||||||||
| JC Aragone LD Martínez | 65 | 7 | [10] | JC Aragone LD Martínez | 3 | 6 | [10] | ||||||||||||||||||||
| M McDonald Ma Redlicki | 77 | 5 | [6] | WC | C Harrison D Novikov | 6 | 5 | [11] | |||||||||||||||||||
| M Krueger J Sock | 78 | 6 | M Krueger J Sock | 4 | 7 | [13] | |||||||||||||||||||||
 A Pavić  R Roelofse | 66 | 3 | M Krueger J Sock | 6 | 6 | ||||||||||||||||||||||
| WC | A Ritschard A Rybakov | 64 | 6 | [18] | WC | A Ritschard A Rybakov | 3 | 3 | |||||||||||||||||||
| 4 | S Balaji J Nedunchezhiyan | 77 | 4 | [16] | M Krueger J Sock | 6 | 6 | ||||||||||||||||||||
| J Menezes T Seyboth Wild | 3 | 6 | [10] | WC | S Bangoura JA Ore | 4 | 3 | ||||||||||||||||||||
B Fratangelo  J Jung | 6 | 4 | [5] | J Menezes T Seyboth Wild | 6 | 3 | [5] | ||||||||||||||||||||
| WC | S Bangoura JA Ore | 6 | 6 | WC | S Bangoura JA Ore | 3 | 6 | [10] | |||||||||||||||||||
| 2 | E King H Reese | 4 | 4 | ||||||||||||||||||||||||
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