Aminoquinolines are derivatives of quinoline, most notable for their roles as antimalarial drugs. Depending upon the location of the amino group, they can be divided into:
After independence in 1964, Malta followed a policy of close co-operation with NATO countries. Since 1971, the country sought relations with the rest of the world, including communist countries in Eastern Europe and the non-aligned countries.
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Quinoline is a heterocyclic aromatic organic compound with the chemical formula C9H7N. It is a colorless hygroscopic liquid with a strong odor. Aged samples, especially if exposed to light, become yellow and later brown. Quinoline is only slightly soluble in cold water but dissolves readily in hot water and most organic solvents. Quinoline itself has few applications, but many of its derivatives are useful in diverse applications. A prominent example is quinine, an alkaloid found in plants. Over 200 biologically active quinoline and quinazoline alkaloids are identified. 4-Hydroxy-2-alkylquinolines (HAQs) are involved in antibiotic resistance.
Mountains named Granite Peak or variations.
Primaquine is a medication used to treat and prevent malaria and to treat Pneumocystis pneumonia. Specifically it is used for malaria due to Plasmodium vivax and Plasmodium ovale along with other medications and for prevention if other options cannot be used. It is an alternative treatment for Pneumocystis pneumonia together with clindamycin. It is taken by mouth.
Hydroxychloroquine, sold under the brand name Plaquenil among others, is a medication used to prevent and treat malaria in areas where malaria remains sensitive to chloroquine. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth, often in the form of hydroxychloroquine sulfate.
8-Aminoquinoline is the 8-amino derivative of quinoline. It is structurally analogous to 8-hydroxyquinoline. The two nitrogen atoms are ideally situated to form complexes with metal ions. Derivatives of 8-aminoquinoline are effective directing groups in organic synthesis.
Pamaquine is an 8-aminoquinoline drug formerly used for the treatment of malaria. It is closely related to primaquine.
Tafenoquine, sold under the brand name Krintafel among others, is a medication used to prevent and to treat malaria. With respect acute malaria it is used together with other medications to prevent relapse by Plasmodium vivax. It may be used to prevent all types of malaria. It is taken by mouth.
Amodiaquine (ADQ) is a medication used to treat malaria, including Plasmodium falciparum malaria when uncomplicated. It is recommended to be given with artesunate to reduce the risk of resistance. Due to the risk of rare but serious side effects, it is not generally recommended to prevent malaria. Though, the WHO in 2013 recommended use for seasonal preventive in children at high risk in combination with sulfadoxine and pyrimethamine.
The Stateville Penitentiary malaria study was a controlled but ethically questionable study of the effects of malaria on the prisoners of Stateville Penitentiary near Joliet, Illinois in the 1940s. The study was conducted by the Department of Medicine at the University of Chicago in conjunction with the United States Army and the State Department. The Stateville experiment was viewed as coercive because it offered shortened sentences to participants. The study is notable for its impacts on the Nuremberg Medical Trial and subsequent medical experimentation on prisoners.
Rhett & Link are an American comedy duo consisting of Rhett McLaughlin and Charles Lincoln "Link" Neal III. Self-styled as "Internetainers", they are known for creating and hosting the YouTube series Good Mythical Morning. Their other notable projects include comedic songs and sketches, their Independent Film Channel series Rhett & Link: Commercial Kings, their YouTube Premium series Rhett and Link's Buddy System, their podcast Ear Biscuits, their novel The Lost Causes of Bleak Creek and their acquisition of Smosh.
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Harry Linn Fisher was the 69th national president of the American Chemical Society, and an authority on the chemistry of vulcanization. Fisher was the author of four popular books on the chemistry and technology of rubber, and the holder of 50 patents.
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