BARHL2

BARHL2
Identifiers
Aliases	BARHL2 , BarH like homeobox 2
External IDs	MGI: 1859314 HomoloGene: 10572 GeneCards: BARHL2
Gene location (Human)
Chr.	Chromosome 1 (human) [1]
End	90,717,237 bp [1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse) [2]
End	106,458,166 bp [2]
Gene ontology
Molecular function	• DNA binding ; • sequence-specific DNA binding ; • RNA polymerase II regulatory region sequence-specific DNA binding ; • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding ; • transcription factor activity, sequence-specific DNA binding ; • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ; • protein binding ; • RNA polymerase II transcription factor activity, sequence-specific DNA binding ;
Cellular component	• Cell nucleus ;
Biological process	• cell fate commitment ; • regulation of transcription, DNA-templated ; • regulation of axon extension ; • regulation of transcription from RNA polymerase II promoter ; • neuron migration ; • transcription from RNA polymerase II promoter ; • positive regulation of translation ; • transcription, DNA-templated ; • nervous system development ; • neuron differentiation ; • cell fate determination ; • positive regulation of transcription from RNA polymerase II promoter ;
	Sources:Amigo / QuickGO
Orthologs
	343472
	104382
	ENSG00000143032
	ENSMUSG00000034384
	Q9NY43
	Q8VIB5
	NM_020063
	NM_001005477
	NP_064447
	NP_001005477
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 12, 2019

BarH-like homeobox 2 is a protein in humans that is encoded by the BARHL2 gene. ^[5]

Protein biological molecule consisting of chains of amino acid residues

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific three-dimensional structure that determines its activity.

In biology, a gene is a sequence of nucleotides in DNA or RNA that codes for a molecule that has a function. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic trait. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes as well as gene–environment interactions. Some genetic traits are instantly visible, such as eye color or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that constitute life.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000143032 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034384 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: BarH-like homeobox 2" . Retrieved 2013-01-04.

BARHL2

Related Research Articles

References

Further reading