Peter J. H. Scott

Last updated

Peter Scott
Peter J. H. Scott.jpg
BornJuly 27, 1979
CitizenshipBritish and American
Education Loughborough University Durham University
AwardsAcademy for Radiology & Biomedical Imaging Research: 2019 Distinguished Investigator Award
Scientific career
Fields Chemistry
Radiochemistry
Positron emission tomography
Nuclear Medicine
Institutions University of Michigan
Thesis Perfluoroalkanesulfonyl linker units for solid phase organic synthesis
Doctoral advisor Patrick G. Steel
Other academic advisors Huw Davies (chemist)

Peter J. H. Scott FRSC CChem (born July 27, 1979) is a British and American chemist and radiochemist who is a professor of radiology, professor of pharmacology and professor of medicinal chemistry, as well as a core member of the Rogel Cancer Center at the University of Michigan in the United States. [1] [2] He is Chief of Nuclear Medicine and director of the University of Michigan Positron Emission Tomography (PET) Center, [3] and runs a research group developing new radiochemistry methodology and novel PET radiotracers. [4]

Contents

Life

Peter Scott was born and grew up in North East England and attended Whitley Bay High School. He received his undergraduate degree with first class honors in medicinal and pharmaceutical chemistry from Loughborough University in 2001, after conducting research with Raymond Jones. He subsequently obtained his PhD in organic chemistry from Durham University in 2005, where he was a member of Ustinov College, under the mentorship of Patrick G. Steel. Scott then moved to the United States to undertake postdoctoral research in organometallic chemistry at SUNY Buffalo under Huw Davies, and PET radiochemistry at the University of Michigan with Michael Kilbourn.

Research

Scott runs a research group developing new metal-catalyzed methods for incorporating fluorine-18 and carbon-11 into bioactive molecules as well as novel PET radiotracers for imaging neurodegenerative disorders. His methodology work aims to improve the synthesis of PET radiotracers and he has an active collaboration with Prof. Melanie Sanford's group [5] that is funded by NIBIB. [6] Together they have developed methods for the Cu-mediated radiofluorination [7] and radiocyanation of (mesityl)(aryl)iodonium salts, [8] boronic acids [9] [10] and stannanes, [10] [11] as well as new methods for radiofluorination of C-H bonds [12] [13] [14] and aryl halides. [15] Scott has also introduced methods for green radiochemistry, [16] for which he received the Michigan Green Chemistry Governor's Award in 2014. [17] In 2019, Prof. Scott was elected as a Fellow of the Royal Society of Chemistry (FRSC), [18] and received a Distinguished Investigator Award from the Academy for Radiology & Biomedical Imaging Research. [19] In 2021, he was honored as a Fellow of the Society of Nuclear Medicine and Molecular Imaging, [20] and was also recognized by SNMMI in 2023 with the Sam Gambhir Trailblazer Award, [21] created to honor the legacy and memory of the late Sanjiv Sam Gambhir.

Bibliography

1. Linker Strategies in Solid-phase Organic Synthesis (Editor, 2009) [22]
2. Solid-Phase Organic Syntheses, Volume 2: Solid-Phase Palladium Chemistry (Wiley Series on Solid-Phase Organic Syntheses) (Editor, 2012) [23]
3. Radiochemical Syntheses: Radiopharmaceuticals for Positron Emission Tomography, Volume 1 (Editor, 2012) [24]
4. Radiochemical Syntheses: Further Radiopharmaceuticals for Positron Emission Tomography and New Strategies for Their Production, Volume 2 (Editor, 2015) [25]
5. Handbook of Radiopharmaceuticals (2nd Edition): Methodology and Applications (Editor, 2021) [26]
6. Production and Quality Control of Fluorine-18 Labelled Radiopharmaceuticals (co-authored with International Atomic Energy Agency, 2021) [27]

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References

  1. ↑ "Radiology | Michigan Medicine | University of Michigan". medicine.umich.edu. January 6, 2014. Retrieved May 1, 2019.
  2. ↑ "Medicinal Chemistry | UM College of Pharmacy". pharmacy.umich.edu. Retrieved May 1, 2019.
  3. ↑ "PET Center | Radiology | Michigan Medicine | University of Michigan". medicine.umich.edu. January 30, 2014. Retrieved May 1, 2019.
  4. ↑ "Peter J. Scott profile". mcommunity.umich.edu.
  5. ↑ Haynes, Sarah (October 3, 2018). "UM scientists improve synthesis of PET imaging molecules". lsa.umich.edu.
  6. ↑ Scott, Peter; Sanford, Melanie. "Copper-mediated Late-Stage Radiofluorination of Electron-rich Arenes".
  7. ↑ Wright, Jay S.; Kaur, Tanpreet; Preshlock, Sean; Tanzey, Sean S.; Winton, Wade P.; Sharninghausen, Liam S.; Wiesner, Nicholas; Brooks, Allen F.; Sanford, Melanie S.; Scott, Peter J. H. (May 26, 2020). "Copper-mediated late-stage radiofluorination: five years of impact on preclinical and clinical PET imaging". Clinical and Translational Imaging. 8 (3): 167–206. doi:10.1007/s40336-020-00368-y. ISSN   2281-5872. PMC   7968072 . PMID   33748018.
  8. ↑ Ichiishi, Naoko; Brooks, Allen F.; Topczewski, Joseph J.; Rodnick, Melissa E.; Sanford, Melanie S.; Scott, Peter J. H. (June 20, 2014). "Copper-Catalyzed [ 18 F]Fluorination of (Mesityl)(aryl)iodonium Salts". Organic Letters. 16 (12): 3224–3227. doi:10.1021/ol501243g. ISSN   1523-7060. PMC   4076000 . PMID   24890658.
  9. ↑ Mossine, Andrew V.; Brooks, Allen F.; Makaravage, Katarina J.; Miller, Jason M.; Ichiishi, Naoko; Sanford, Melanie S.; Scott, Peter J. H. (December 4, 2015). "Synthesis of [18F]Arenes via the Copper-Mediated [18F]Fluorination of Boronic Acids". Organic Letters. 17 (23): 5780–5783. doi:10.1021/acs.orglett.5b02875. ISSN   1523-7060. PMC   4672358 . PMID   26568457.
  10. 1 2 Makaravage, Katarina J.; Shao, Xia; Brooks, Allen F.; Yang, Lingyun; Sanford, Melanie S.; Scott, Peter J. H. (February 27, 2018). "Copper(II)-Mediated [11C]Cyanation of Arylboronic Acids and Arylstannanes". Organic Letters. 20 (6): 1530–1533. doi:10.1021/acs.orglett.8b00242. ISSN   1523-7060. PMC   5892454 . PMID   29484880.
  11. ↑ Makaravage, Katarina J.; Brooks, Allen F.; Mossine, Andrew V.; Sanford, Melanie S.; Scott, Peter J. H. (October 10, 2016). "Copper-Mediated Radiofluorination of Arylstannanes with [18F]KF". Organic Letters. 18 (20): 5440–5443. doi:10.1021/acs.orglett.6b02911. ISSN   1523-7060. PMC   5078836 . PMID   27718581.
  12. ↑ McCammant, Matthew S.; Thompson, Stephen; Brooks, Allen F.; Krska, Shane W.; Scott, Peter J. H.; Sanford, Melanie S. (July 21, 2017). "Cu-Mediated C–H 18F-Fluorination of Electron-Rich (Hetero)arenes". Organic Letters. 19 (14): 3939–3942. doi:10.1021/acs.orglett.7b01902. ISSN   1523-7060. PMC   5525103 . PMID   28665619.
  13. ↑ Lee, So Jeong; Makaravage, Katarina J.; Brooks, Allen F.; Scott, Peter J. H.; Sanford, Melanie S. (January 18, 2019). "Copper-Mediated Aminoquinoline-Directed Radiofluorination of Aromatic C−H Bonds with K18F". Angewandte Chemie International Edition. 58 (10): 3119–3122. doi:10.1002/anie.201812701. ISSN   1433-7851. PMC   6476334 . PMID   30605563.
  14. ↑ Lee, So Jeong; Brooks, Allen F.; Ichiishi, Naoko; Makaravage, Katarina J.; Mossine, Andrew V.; Sanford, Melanie S.; Scott, Peter J. H. (2019). "C–H 18F-fluorination of 8-methylquinolines with Ag[18F]F". Chemical Communications. 55 (20): 2976–2979. doi:10.1039/c9cc00641a. ISSN   1359-7345. PMC   6556205 . PMID   30778496.
  15. ↑ Sharninghausen, Liam S.; Brooks, Allen F.; Winton, Wade P.; Makaravage, Katarina J.; Scott, Peter J. H.; Sanford, Melanie S. (2020). "NHC-Copper Mediated Ligand-Directed Radiofluorination of Aryl Halides". Journal of the American Chemical Society. 142 (16): 7362–7367. doi:10.1021/jacs.0c02637. ISSN   0002-7863. PMC   7314054 . PMID   32250612.
  16. ↑ Stewart, Megan N.; Hockley, Brian G.; Scott, Peter J. H. (2015). "Green approaches to late-stage fluorination: radiosyntheses of 18F-labelled radiopharmaceuticals in ethanol and water". Chemical Communications. 51 (79): 14805–14808. doi:10.1039/c5cc05919d. ISSN   1359-7345. PMID   26300287.
  17. ↑ "Michigan Green Chemistry Governor's Awards Program". michigan.gov.
  18. ↑ Fellows. The Times, March 12, 2019, p. 55, col. E&F.
  19. ↑ "The Academy for Radiology & Biomedical Imaging Research Announces the Recipients of its Eighth Annual Distinguished Investigator Award" (PDF). acadrad.org.
  20. ↑ "SNMMI Fellows". snmmi.org.
  21. ↑ "Peter J. H. Scott, PhD, Receives SNMMI Sam Gambhir Trailblazer Award". snmmi.org.
  22. ↑ Linker Strategies in Solid-phase Organic Synthesis; https://onlinelibrary.wiley.com/doi/book/10.1002/9780470749043
  23. ↑ Solid-Phase Organic Syntheses, Volume 2: Solid-Phase Palladium Chemistry (Wiley Series on Solid-Phase Organic Syntheses); https://onlinelibrary.wiley.com/doi/book/10.1002/9781118336953
  24. ↑ Radiochemical Syntheses: Radiopharmaceuticals for Positron Emission Tomography, Volume 1; https://onlinelibrary.wiley.com/doi/book/10.1002/9781118140345
  25. ↑ Radiochemical Syntheses: Further Radiopharmaceuticals for Positron Emission Tomography and New Strategies for Their Production, Volume 2; https://onlinelibrary.wiley.com/doi/book/10.1002/9781118834114
  26. ↑ Handbook of Radiopharmaceuticals; https://onlinelibrary.wiley.com/doi/book/10.1002/9781119500575
  27. ↑ Production and Quality Control of Fluorine-18 Labelled Radiopharmaceuticals; https://www.iaea.org/publications/14925/production-and-quality-control-of-fluorine-18-labelled-radiopharmaceuticals
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