Vitaliy Khutoryanskiy

Last updated
Vitaliy Khutoryanskiy
Born (1975-05-01) May 1, 1975 (age 49)
Alma materAl-Farabi Kazakh National University
EmployerUniversity of Reading
Known forhis research on interpolymer complexes, water-soluble polymers, hydrogels, functionalized nanoparticles and drug delivery
Website https://www.reading.ac.uk/pharmacy/staff/professor-vitaliy-khutoryanskiy

Vitaliy Khutoryanskiy FRSC is a British and Kazakhstani scientist, a Professor of Formulation Science and a Royal Society Industry Fellow at the University of Reading. [1] His research focuses on polymers, biomaterials, nanomaterials, drug delivery, and pharmaceutical sciences. Khutoryanskiy has published over 200 original research articles, book chapters, and reviews. His publications have attracted > 11000 citations and his current h-index is 52. [2] He received several prestigious awards in recognition for his research in polymers, colloids and drug delivery [3] [4] as well as for contributions to research peer-review [5] and mentoring of early career researchers. [6] He holds several honorary professorship titles from different universities. [7]

Contents

Education and career

Khutoryanskiy was born and grew up in Almaty, Kazakhstan. [8] He studied at Al-Farabi Kazakh National University, graduating with a BSc in Chemistry in 1996. He earned his MSc in Polymer Chemistry in 1998, and then his PhD in Polymer Chemistry in 2000, both from the same institution. His PhD project was focused on the studies of hydrogen-bonded interpolymer complexes and preparation of hydrophilic films. [9] [10] During his PhD studies, he also spent 4 months in the research group of Janusz Rosiak at Łódź University of Technology, Poland, [8] where specialised in radiation chemistry of hydrophilic polymers. [11] He worked as a Lecturer in Polymer Science at Al-Farabi Kazakh National University in 2000-2002. [12] In 2002, he moved to the United Kingdom and joined the research group of Ijeoma Uchegbu at the University of Strathclyde as a postdoctoral research assistant, where worked on the synthesis of chitosan amphiphiles and their studies for drug delivery. [13] In 2004, he moved to the University of Manchester to work as a postdoctoral research assistant of Nicola Tirelli, studying the design of oxidation-responsive nanoparticles. [14] In 2005, Khutoryanskiy was appointed as a Lecturer in Pharmaceutics at newly-established Reading School of Pharmacy, University of Reading. In 2010, he was promoted to Reader (Associate Professor) in Pharmaceutical Materials and in 2014, he became full Professor of Formulation Science. [8] [12] In 2023, he became the founding director of the Physicochemical, Ex Vivo and Invertebrate Tests and Analysis Centre (PEVITAC) at the University of Reading.

Research

Earlier research of Khutoryanskiy was focused on the studies of hydrogen-bonded interpolymer complexes formed by poly(carboxylic acids) and various non-ionic polymers in aqueous and organic solvents. He established the factors affecting the complexation between polymers such as solvent nature, pH and ionic strength of solutions, nature and molecular weight of interacting polymers as well as environmental temperature. [10] [15] [16] He also researched radiation-mediated grafting of hydrophilic polymers on polyolefin surfaces [17] and complexes formed between linear polymers and hydrogels. [18] His current research broadly focuses on water-soluble polymers, colloids and hydrogels for applications in drug delivery, biomaterials, and various formulations (food technology, health care products and agrochemicals). His group has pioneered several new families of polymers and nanomaterials with enhanced mucoadhesive properties, [19] [20] [21] they also were the first to develop mucosa-mimetic polymeric hydrogels that can be used in place of animal tissues to study mucoadhesive dosage forms [22] [23] [24] and demonstrated that nanoparticles decorated with poly(2-oxazolines), poly(2-hydroxyethylacrylate) and poly(N-vinylpyrrolidone) exhibit mucus-penetrating properties similar to PEGylated nanocarriers. [25] [26] His other significant research contributions include the new synthesis of thiolated silica nanoparticles, [27] which were subsequently commercialised by PolySciTech; [28] studies of novel ocular penetration enhancers, [29] [30] nanoparticles penetration into various biological membranes, [31] formulation of encapsulated probiotic bacteria, [32] [33] new method for synthesis of hydrogels, [34] development of new toxicological assays using planaria [35] [36] and the use of various poly(2-oxazolines) for preparation of solid drug dispersions [37] and iodophors. [38]

Books

He edited and co-edited several books [39]

Awards and honours

Professional services

Khutoryanskiy serves on editorial boards of several international journals, including European Polymer Journal (Elsevier), [47] Journal of Pharmaceutical Sciences (Elsevier), [48] Pharmaceutics (MDPI), [49] Polymers (MDPI), [50] Gels (MDPI) [51] and Reviews and Advanced in Chemistry (Springer). [52] Also he is associate editor and member of journal editorial boards of several national journals in Kazakhstan, [53] [54] Uzbekistan [55] and Russia. [56] He guest edited several special issues of Pharmaceutics, Polymers, Gels and Polymers for Advanced Technologies. [57] He is a committee member of Macro Group UK (RSC & SCI Pure and Applied Macromolecular Chemistry Group) [58] and Engineering and Physical Sciences Research Council (EPSRC) peer-review college member. [59] He was involved in organisation of many conferences and symposia as a chair, co-chair and member of organising committees. [60] [61] [62] [63] He is recognised for his outstanding contributions to research peer review and mentoring of early career researchers. [5] Khutoryanskiy has also made substantial contribution to the development of research, training and education of students and researchers at various universities in Kazakhstan. [64] [65] [66] [67] [68] [69] [70] [71]

Related Research Articles

<span class="mw-page-title-main">Hydrogel</span> Soft water-rich polymer gel

A hydrogel is a biphasic material, a mixture of porous, permeable solids and at least 10% by weight or volume of interstitial fluid composed completely or mainly by water. In hydrogels the porous permeable solid is a water insoluble three dimensional network of natural or synthetic polymers and a fluid, having absorbed a large amount of water or biological fluids. These properties underpin several applications, especially in the biomedical area. Many hydrogels are synthetic, but some are derived from nature. The term 'hydrogel' was coined in 1894.

<span class="mw-page-title-main">Alginic acid</span> Polysaccharide found in brown algae

Alginic acid, also called algin, is a naturally occurring, edible polysaccharide found in brown algae. It is hydrophilic and forms a viscous gum when hydrated. With metals such as sodium and calcium, its salts are known as alginates. Its colour ranges from white to yellowish-brown. It is sold in filamentous, granular, or powdered forms.

<span class="mw-page-title-main">Maleimide</span> Chemical compound

Maleimide is a chemical compound with the formula H2C2(CO)2NH (see diagram). This unsaturated imide is an important building block in organic synthesis. The name is a contraction of maleic acid and imide, the -C(O)NHC(O)- functional group. Maleimides also describes a class of derivatives of the parent maleimide where the NH group is replaced with alkyl or aryl groups such as a methyl or phenyl, respectively. The substituent can also be a small molecule (such as biotin, a fluorescent dye, an oligosaccharide, or a nucleic acid), a reactive group, or a synthetic polymer such as polyethylene glycol. Human hemoglobin chemically modified with maleimide-polyethylene glycol is a blood substitute called MP4.

Thiolated polymers – designated thiomers – are functional polymers used in biotechnology product development with the intention to prolong mucosal drug residence time and to enhance absorption of drugs. The name thiomer was coined by Andreas Bernkop-Schnürch in 2000. Thiomers have thiol bearing side chains. Sulfhydryl ligands of low molecular mass are covalently bound to a polymeric backbone consisting of mainly biodegradable polymers, such as chitosan, hyaluronic acid, cellulose derivatives, pullulan, starch, gelatin, polyacrylates, cyclodextrins, or silicones.

Small-angle X-ray scattering (SAXS) is a small-angle scattering technique by which nanoscale density differences in a sample can be quantified. This means that it can determine nanoparticle size distributions, resolve the size and shape of (monodisperse) macromolecules, determine pore sizes, characteristic distances of partially ordered materials, and much more. This is achieved by analyzing the elastic scattering behaviour of X-rays when travelling through the material, recording their scattering at small angles. It belongs to the family of small-angle scattering (SAS) techniques along with small-angle neutron scattering, and is typically done using hard X-rays with a wavelength of 0.07 – 0.2 nm. Depending on the angular range in which a clear scattering signal can be recorded, SAXS is capable of delivering structural information of dimensions between 1 and 100 nm, and of repeat distances in partially ordered systems of up to 150 nm. USAXS can resolve even larger dimensions, as the smaller the recorded angle, the larger the object dimensions that are probed.

<span class="mw-page-title-main">Polyacrylic acid</span> Anionic polyelectrolyte polymer

Poly(acrylic acid) (PAA; trade name Carbomer) is a polymer with the formula (CH2-CHCO2H)n. It is a derivative of acrylic acid (CH2=CHCO2H). In addition to the homopolymers, a variety of copolymers and crosslinked polymers, and partially deprotonated derivatives thereof are known and of commercial value. In a water solution at neutral pH, PAA is an anionic polymer, i.e., many of the side chains of PAA lose their protons and acquire a negative charge. Partially or wholly deprotonated PAAs are polyelectrolytes, with the ability to absorb and retain water and swell to many times their original volume. These properties – acid-base and water-attracting – are the bases of many applications.

Mucoadhesion describes the attractive forces between a biological material and mucus or mucous membrane. Mucous membranes adhere to epithelial surfaces such as the gastrointestinal tract (GI-tract), the vagina, the lung, the eye, etc. They are generally hydrophilic as they contain many hydrogen macromolecules due to the large amount of water within its composition. However, mucin also contains glycoproteins that enable the formation of a gel-like substance. Understanding the hydrophilic bonding and adhesion mechanisms of mucus to biological material is of utmost importance in order to produce the most efficient applications. For example, in drug delivery systems, the mucus layer must be penetrated in order to effectively transport micro- or nanosized drug particles into the body. Bioadhesion is the mechanism by which two biological materials are held together by interfacial forces. The mucoadhesive properties of polymers can be evaluated via rheological synergism studies with freshly isolated mucus, tensile studies and mucosal residence time studies. Results obtained with these in vitro methods show a high correlation with results obtained in humans.

A nanogel is a polymer-based, crosslinked hydrogel particle on the sub-micron scale. These complex networks of polymers present a unique opportunity in the field of drug delivery at the intersection of nanoparticles and hydrogel synthesis. Nanogels can be natural, synthetic, or a combination of the two and have a high degree of tunability in terms of their size, shape, surface functionalization, and degradation mechanisms. Given these inherent characteristics in addition to their biocompatibility and capacity to encapsulate small drugs and molecules, nanogels are a promising strategy to treat disease and dysfunction by serving as delivery vehicles capable of navigating across challenging physiological barriers within the body. 

Nanocomposite hydrogels are nanomaterial-filled, hydrated, polymeric networks that exhibit higher elasticity and strength relative to traditionally made hydrogels. A range of natural and synthetic polymers are used to design nanocomposite network. By controlling the interactions between nanoparticles and polymer chains, a range of physical, chemical, and biological properties can be engineered. The combination of organic (polymer) and inorganic (clay) structure gives these hydrogels improved physical, chemical, electrical, biological, and swelling/de-swelling properties that cannot be achieved by either material alone. Inspired by flexible biological tissues, researchers incorporate carbon-based, polymeric, ceramic and/or metallic nanomaterials to give these hydrogels superior characteristics like optical properties and stimulus-sensitivity which can potentially be very helpful to medical and mechanical fields.

Soodabeh Davaran is an Iranian researcher, and professor of polymer chemistry in the Faculty of Pharmacy in Tabriz University of Medical Sciences. She has written many articles about chemistry. Some of her scientific articles have been retracted because of figure manipulation and misconduct.

<span class="mw-page-title-main">Andreas Bernkop-Schnürch</span> Austrian university teacher (born 1965)

Andreas Bernkop-Schnürch is an Austrian scientist and entrepreneur, who is Head of the Department of Pharmaceutical Technology in the Institute of Pharmacy at the University of Innsbruck.

<span class="mw-page-title-main">Ophthalmic drug administration</span>

Ophthalmic drug administration is the administration of a drug to the eyes, most typically as an eye drop formulation. Topical formulations are used to combat a multitude of diseased states of the eye. These states may include bacterial infections, eye injury, glaucoma, and dry eye. However, there are many challenges associated with topical delivery of drugs to the cornea of the eye.

<span class="mw-page-title-main">Heather Maynard</span> American chemist

Heather D. Maynard is the Dr Myung Ki Hong Professor in Polymer Science at the University of California, Los Angeles. She works on protein-polymer conjugates and polymeric drugs. Maynard is a Fellow of the Royal Society of Chemistry and the American Association for the Advancement of Science.

Interpolymer complexes (IPC) are the products of non-covalent interactions between complementary unlike macromolecules in solutions. There are foiur types of these complexes:

Hamid Ghandehari is an Iranian-American drug delivery research scientist, and a professor in the Departments of Pharmaceutics and Pharmaceutical Chemistry and Biomedical Engineering at the University of Utah. His research is focused in recombinant polymers for drug and gene delivery, nanotoxicology of dendritic and inorganic constructs, water-soluble polymers for targeted delivery and poly(amidoamine) dendrimers for oral delivery.

<span class="mw-page-title-main">Dextran drug delivery systems</span> Polymeric drug carrier

Dextran drug delivery systems involve the use of the natural glucose polymer dextran in applications as a prodrug, nanoparticle, microsphere, micelle, and hydrogel drug carrier in the field of targeted and controlled drug delivery. According to several in vitro and animal research studies, dextran carriers reduce off-site toxicity and improve local drug concentration at the target tissue site. This technology has significant implications as a potential strategy for delivering therapeutics to treat cancer, cardiovascular diseases, pulmonary diseases, bone diseases, liver diseases, colonic diseases, infections, and HIV.

Pullulan bioconjugates are systems that use pullulan as a scaffold to attach biological materials to, such as drugs. These systems can be used to enhance the delivery of drugs to specific environments or the mechanism of delivery. These systems can be used in order to deliver drugs in response to stimuli, create a more controlled and sustained release, and provide a more targeted delivery of certain drugs.

Chitosan-poly is a composite that has been increasingly used to create chitosan-poly(acrylic acid) nanoparticles. More recently, various composite forms have come out with poly(acrylic acid) being synthesized with chitosan which is often used in a variety of drug delivery processes. Chitosan which already features strong biodegradability and biocompatibility nature can be merged with polyacrylic acid to create hybrid nanoparticles that allow for greater adhesion qualities as well as promote the biocompatibility and homeostasis nature of chitosan poly(acrylic acid) complex. The synthesis of this material is essential in various applications and can allow for the creation of nanoparticles to facilitate a variety of dispersal and release behaviors and its ability to encapsulate a multitude of various drugs and particles.

Intranasal drug delivery occurs when particles are inhaled into the nasal cavity and transported directly into the nervous system. Though pharmaceuticals can be injected into the nose, some concerns include injuries, infection, and safe disposal. Studies demonstrate improved patient compliance with inhalation. Treating brain diseases has been a challenge due to the blood brain barrier. Previous studies evaluated the efficacy of delivery therapeutics through intranasal route for brain diseases and mental health conditions. Intranasal administration is a potential route associated with high drug transfer from nose to brain and drug bioavailability.

<span class="mw-page-title-main">Intravesical drug delivery</span> Intravesical drug delivery, drug delivery to the bladder

Intravesical drug delivery is the delivery of medications directly into the bladder by urinary catheter. This method of drug delivery is used to directly target diseases of the bladder such as interstitial cystitis and bladder cancer, but currently faces obstacles such as low drug retention time due to washing out with urine and issues with the low permeability of the bladder wall itself. Due to the advantages of directly targeting the bladder, as well as the effectiveness of permeability enhancers, advances in intravesical drug carriers, and mucoadhesive, intravesical drug delivery is becoming more effective and of increased interest in the medical community.

References

  1. ↑ "University of Reading webpage of Prof Vitaliy Khutoryanskiy".
  2. ↑ "Scopus preview – Khutoryanskiy, Vitaliy V. – Author details – Scopus". www.scopus.com. Retrieved 2022-09-05.
  3. 1 2 "PHARMACY ACADEMIC AWARDED MEDAL FOR RESEARCH INTO NEW MATERIALS".
  4. 1 2 "Sticky and slippery drug materials award – University of Reading". www.reading.ac.uk. Retrieved 2022-06-11.
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  6. 1 2 "Postgraduate research supervisor at Reading 'best in UK'". Reading Chronicle. 31 August 2020. Retrieved 2022-06-11.
  7. 1 2 "'STICKY DRUGS' ACADEMIC RECEIVES HONOUR FROM PRESTIGIOUS RUSSIAN UNIVERSITY".
  8. 1 2 3 ""Best PhD supervisor in the UK[1]" discusses pharmaceutics, teaching and karate".
  9. ↑ Z.S., Nurkeeva; G.A., Mun; V.V., Khutoryanskiy (2001). "Interpolymer complexes of poly(glycol vinyl ethers) and related composite materials". Высокомолекулярные соединения. Серия Б. 43 (5): 925–935. ISSN   2308-1139.
  10. 1 2 Mun, Grigoriy A.; Nurkeeva, Zauresh S.; Khutoryanskiy, Vitaliy V.; Bitekenova, Asem B. (2000). "Effect of copolymer composition on interpolymer complex formation of (co)poly(vinyl ether)s with poly(acrylic acid) in aqueous and organic solutions". Macromolecular Rapid Communications. 21 (7): 381–384. doi:10.1002/(SICI)1521-3927(20000401)21:7<381::AID-MARC381>3.0.CO;2-B.
  11. ↑ Khutoryanskiy, Vitaliy V.; Kujawa, Piotr; Nurkeeva, Zauresh S.; Rosiak, Janusz M. (2001-04-01). <1089::aid-macp1089>3.0.co;2-s "Radiation Synthesis of Linear and Crosslinked Poly[2-(methacryloyloxy)ethyl]trimethylammonium Chloride and Complex Formation with Potassium Hexacyanoferrates (II, III) in Aqueous Solutions". Macromolecular Chemistry and Physics. 202 (7): 1089–1093. doi:10.1002/1521-3935(20010401)202:7<1089::aid-macp1089>3.0.co;2-s. ISSN   1022-1352.
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  14. ↑ Khutoryanskiy, Vitaliy V.; Tirelli, Nicola (2008-01-01). "Oxidation-responsiveness of nanomaterials for targeting inflammatory reactions". Pure and Applied Chemistry. 80 (8): 1703–1718. doi: 10.1351/pac200880081703 . ISSN   1365-3075. S2CID   55012679.
  15. ↑ Khutoryanskiy, Vitaliy V.; Dubolazov, Artem V.; Nurkeeva, Zauresh S.; Mun, Grigoriy A. (2004-04-01). "pH Effects in the Complex Formation and Blending of Poly(acrylic acid) with Poly(ethylene oxide)". Langmuir. 20 (9): 3785–3790. doi:10.1021/la049807l. ISSN   0743-7463. PMID   15875416.
  16. ↑ Khutoryanskiy, Vitaliy V; Mun, Grigoriy A; Nurkeeva, Zauresh S; Dubolazov, Artem V (September 2004). "pH and salt effects on interpolymer complexation via hydrogen bonding in aqueous solutions". Polymer International. 53 (9): 1382–1387. doi: 10.1002/pi.1549 . ISSN   0959-8103.
  17. ↑ Aal, Al-Sayed Abdel; Khutoryanskiy, Vitaliy V.; Nurkeeva, Zauresh S.; Mun, Grigoriy A. (2002-08-30). "Radiation grafting of vinyl ether of monoethanolamine on polypropylene films for application in waste water treatment". Journal of Materials Chemistry. 12 (9): 2692–2695. doi:10.1039/B202689A. ISSN   1364-5501.
  18. ↑ Khutoryanskiy, Vitaliy V.; Nurkeeva, Zauresh S.; Mun, Grigoriy A.; Sergaziyev, Aibek D.; Ryskalieva, Zhanna; Rosiak, Janusz M. (2003-04-01). "Polyelectrolyte complexes of soluble poly-2-[(methacryloyloxy)ethyl]trimethylammonium chloride and its hydrogels with poly(acrylic acid)". European Polymer Journal. 39 (4): 761–766. doi:10.1016/S0014-3057(02)00293-8. ISSN   0014-3057.
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  21. ↑ Brotherton, Emma E.; Neal, Thomas J.; Kaldybekov, Daulet B.; Smallridge, Mark J.; Khutoryanskiy, Vitaliy V.; Armes, Steven P. (2022-05-26). "Aldehyde-functional thermoresponsive diblock copolymer worm gels exhibit strong mucoadhesion". Chemical Science. 13 (23): 6888–6898. doi:10.1039/D2SC02074B. ISSN   2041-6539. PMC   9200053 . PMID   35774174. S2CID   249114990.
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  26. ↑ Ways, Twana Mohammed M.; Filippov, Sergey K.; Maji, Samarendra; Glassner, Mathias; Cegłowski, Michal; Hoogenboom, Richard; King, Stephen; Lau, Wing Man; Khutoryanskiy, Vitaliy V. (2022-11-15). "Mucus-penetrating nanoparticles based on chitosan grafted with various non-ionic polymers: Synthesis, structural characterisation and diffusion studies". Journal of Colloid and Interface Science. 626: 251–264. Bibcode:2022JCIS..626..251W. doi: 10.1016/j.jcis.2022.06.126 . hdl: 1854/LU-01GMB2BX6RPB3ZQDS6N7YQC2HW . ISSN   0021-9797. PMID   35797869. S2CID   250097398.
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  68. ↑ "History of the Department of Macromolecular Chemistry at Al-Farabi Kazakh National University". www.kaznu.kz. Retrieved 2022-09-04.
  69. ↑ "Article about Prof Khutoryanskiy in Qazaq Universiti magazine (in Kazakh)" (PDF).
  70. ↑ "Visit of Prof Khutoryanskiy to Medical University of Semey" (in Russian). 2018-03-30. Retrieved 2023-01-03.
  71. ↑ "Учёный из Великобритании читает лекции в университете Жубанова — Новости Университета Жубанова". news-ru.arsu.kz. Retrieved 2023-04-06.
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