AZGP1

AZGP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1T7V, 1T7W, 1T7X, 1T7Y, 1T7Z, 1T80, 1ZAG, 3ES6
Identifiers
Aliases	AZGP1 , ZA2G, ZAG, alpha-2-glycoprotein 1, zinc-binding
External IDs	OMIM: 194460 MGI: 103163 HomoloGene: 915 GeneCards: AZGP1
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q22.1 Start 99,966,720 bp [1] End 99,976,042 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5 G2|5 76.92 cM Start 137,979,782 bp [2] End 137,988,495 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland right lobe of liver trachea body of pancreas lactiferous duct skin of abdomen prostate minor salivary gland urethra nipple Top expressed in left lobe of liver gallbladder lacrimal gland superior surface of tongue parotid gland proximal tubule olfactory epithelium epithelium of stomach kidney pyloric antrum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein transmembrane transporter activity ribonuclease activity protein binding Cellular component plasma membrane extracellular exosome nucleus extracellular space extracellular matrix extracellular region collagen-containing extracellular matrix external side of plasma membrane Biological process detection of chemical stimulus involved in sensory perception of bitter taste retina homeostasis cell adhesion transmembrane transport negative regulation of cell population proliferation protein transmembrane transport RNA phosphodiester bond hydrolysis immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 563 12007 Ensembl ENSG00000160862 ENSMUSG00000037053 UniProt P25311 Q64726 RefSeq (mRNA) NM_001185 NM_013478 RefSeq (protein) NP_001176 NP_038506 Location (UCSC) Chr 7: 99.97 – 99.98 Mb Chr 5: 137.98 – 137.99 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc-alpha-2-glycoprotein is a protein that in humans is encoded by the AZGP1 gene. ^{[5] [6]}

This gene expresses a soluble protein that stimulates lipolysis, induces a reduction in body fat in mice, is associated with the cachexia related to cancer, and is known to be expressed in secretory cells of lung epithelium. ^[7] In 2009, it was found that smoking increases expression of this gene, which is why smoking cessation leads to weight gain. ^[7] Zinc-alpha-2-glycoprotein levels also rise with onset of diabetes 2, which accounts for weight loss thereafter.^{[ citation needed ]}

References

1. GRCh38: Ensembl release 89: ENSG00000160862 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037053 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ueyama H, Niwa M, Tada T, Sasaki M, Ohkubo I (Jul 1991). "Cloning and nucleotide sequence of a human Zn-alpha 2-glycoprotein cDNA and chromosomal assignment of its gene". Biochem Biophys Res Commun. 177 (2): 696–703. doi:10.1016/0006-291X(91)91844-3. PMID   2049092.
6. "Entrez Gene: AZGP1 alpha-2-glycoprotein 1, zinc-binding".
7. Vanni H, Kazeros A, Wang R, Harvey BG, Ferris B, De BP, Carolan BJ, Hübner RH, et al. (2009). "Cigarette Smoking Induces Overexpression of a Fat-Depleting Gene AZGP1 in the Human". Chest. 135 (5): 1197–208. doi:10.1378/chest.08-1024. PMC   2679098 . PMID   19188554.

External links

• Human AZGP1 genome location and AZGP1 gene details page in the UCSC Genome Browser .

Further reading

• Freije JP, Fueyo A, Uría J, López-Otín C (1991). "Human Zn-alpha 2-glycoprotein cDNA cloning and expression analysis in benign and malignant breast tissues". FEBS Lett. 290 (1–2): 247–9. doi:10.1016/0014-5793(91)81271-9. PMID   1915885. S2CID   2058665.
• Tada T, Ohkubo I, Niwa M, et al. (1991). "Immunohistochemical localization of Zn-alpha 2-glycoprotein in normal human tissues". J. Histochem. Cytochem. 39 (9): 1221–6. doi:10.1177/39.9.1918940. PMID   1918940. S2CID   687025.
• Araki T, Gejyo F, Takagaki K, et al. (1988). "Complete amino acid sequence of human plasma Zn-alpha 2-glycoprotein and its homology to histocompatibility antigens". Proc. Natl. Acad. Sci. U.S.A. 85 (3): 679–83. doi: 10.1073/pnas.85.3.679 . PMC   279618 . PMID   3422450.
• Shibata S, Miura K (1982). "Nephritogenic glycoprotein. IX. Plasma Zn-alpha2-glycoprotein as a second source of nephritogenic glycoprotein in urine". Nephron. 31 (2): 170–6. doi:10.1159/000182638. PMID   6896906.
• Ueyama H, Deng HX, Ohkubo I (1994). "Molecular cloning and chromosomal assignment of the gene for human Zn-alpha 2-glycoprotein". Biochemistry. 32 (48): 12968–76. doi:10.1021/bi00211a004. PMID   8241150.
• Freije JP, Fueyo A, Uría JA, et al. (1994). "Human Zn-alpha 2-glycoprotein: complete genomic sequence, identification of a related pseudogene and relationship to class I major histocompatibility complex genes". Genomics. 18 (3): 575–87. doi:10.1016/S0888-7543(05)80359-3. PMID   8307568.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Sánchez LM, López-Otín C, Bjorkman PJ (1997). "Biochemical characterization and crystalization of human Zn-alpha2-glycoprotein, a soluble class I major histocompatibility complex homolog". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4626–30. doi: 10.1073/pnas.94.9.4626 . PMC   20774 . PMID   9114041.
• Brysk MM, Lei G, Rajaraman S, et al. (1997). "Gene expression of zinc-alpha 2-glycoprotein in normal human epidermal and buccal epithelia". In Vivo. 11 (3): 271–4. PMID   9239523.
• Lei G, Arany I, Selvanayagam P, et al. (1997). "Detection and cloning of epidermal zinc-alpha 2-glycoprotein cDNA and expression in normal human skin and in tumors". J. Cell. Biochem. 67 (2): 216–22. doi:10.1002/(SICI)1097-4644(19971101)67:2<216::AID-JCB6>3.0.CO;2-#. PMID   9328826. S2CID   196585165.
• Ogikubo O, Maeda T, Yamane T, et al. (1998). "Regulation of Zn-alpha2-glycoprotein-mediated cell adhesion by kininogens and their derivatives". Biochem. Biophys. Res. Commun. 252 (1): 257–62. doi:10.1006/bbrc.1998.9614. PMID   9813179.
• Sánchez LM, Chirino AJ, Bjorkman P (1999). "Crystal structure of human ZAG, a fat-depleting factor related to MHC molecules". Science. 283 (5409): 1914–9. Bibcode:1999Sci...283.1914S. doi:10.1126/science.283.5409.1914. PMID   10206894.
• Lei G, Brysk H, Arany I, et al. (1999). "Characterization of zinc-alpha(2)-glycoprotein as a cell adhesion molecule that inhibits the proliferation of an oral tumor cell line". J. Cell. Biochem. 75 (1): 160–9. doi:10.1002/(SICI)1097-4644(19991001)75:1<160::AID-JCB16>3.0.CO;2-B. PMID   10462714. S2CID   11549967.
• Davidsson P, Nilsson CL (2000). "Peptide mapping of proteins in cerebrospinal fluid utilizing a rapid preparative two-dimensional electrophoretic procedure and matrix-assisted laser desorption/ionization mass spectrometry". Biochim. Biophys. Acta. 1473 (2–3): 391–9. doi:10.1016/s0304-4165(99)00197-x. PMID   10594376.
• Kennedy MW, Heikema AP, Cooper A, et al. (2001). "Hydrophobic ligand binding by Zn-alpha 2-glycoprotein, a soluble fat-depleting factor related to major histocompatibility complex proteins". J. Biol. Chem. 276 (37): 35008–13. doi: 10.1074/jbc.C100301200 . PMID   11425849.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID   12853948.
• BURGI W, SCHMID K (1998). "Preparation and properties of Zn-alpha 2-glycoprotein of normal human plasma". J. Biol. Chem. 236 (4): 1066–74. doi: 10.1016/S0021-9258(18)64243-7 . PMID   13689030.