Acid ash hypothesis

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The acid-ash hypothesis is a medical hypothesis which suggests that excessively acidic diets may result in a number of identifiable health effects, including an increased risk of osteoporosis. [1] It has received some attention in the lay community, and has been used to support the diet known as the Alkaline diet. [1] According to the hypothesis, acid ash is produced by meat, poultry, cheese, fish, eggs, and grains. Alkaline ash is produced by fruits and vegetables, except cranberries, prunes and plums. Since the acid or alkaline ash designation is based on the residue left on combustion rather than the acidity of the food, foods such as citrus fruits that are generally considered acidic are actually considered alkaline producing in this diet. [2]

Contents

Research

Recent systematic reviews have been published which have methodically analyzed the weight of available scientific evidence, and have found no significant evidence to support the acid–ash hypothesis in regard to prevention of osteoporosis.

Furthermore, a meta-analysis of studies on the effect of dietary phosphate intake contradicted the expected results under the acid–ash hypothesis with respect to calcium in the urine and bone metabolism. This result suggests use of this diet to prevent calcium loss from bone is not justified. [3] Other meta-analyses which have investigated the effect of total dietary acid intake have also found no evidence that acid intake increases the risk for osteoporosis as would be expected under the acid-ash hypothesis. [4] [5]

Another review looked at the effects of dairy product intake, which have been hypothesized to increase the acid load of the body through phosphate and protein components. This review found no significant evidence suggesting dairy product intake causes acidosis or increases risk for osteoporosis. [6] A meta-analysis on the effects of alkaline potassium salts on calcium metabolism and bone health found that supplementation with alkaline potassium salts reduces loss of calcium in urine and reduces acid secretion. [7]

Relation to alkaline diets

The acid ash hypothesis suggests that diets high in "acid ash" (acid producing) elements would cause the body to try to buffer (or counteract) any additional acid load in the body by breaking down bone, leading to weaker bones and increased risk for osteoporosis. Consequently, "alkaline ash" (alkaline producing) elements would hypothetically decrease the risk of osteoporosis. This hypothesis has been advanced in a position statement of the Academy of Nutrition and Dietetics, [2] in a publication of the U.S. National Academy of Sciences, [8] as well as other scientific publications, [4] which have stated foods high in potassium and magnesium such as fruits and vegetables may decrease the risk of osteoporosis through increased alkaline ash production. However, this acceptance of the acid-ash hypothesis as a major modifiable risk factor of osteoporosis by these publications was largely made without significant critical review by high quality systematic analysis. [3]

It has also been speculated that an alkaline diet may have an effect on muscle wasting, growth hormone metabolism or back pain, though there is no conclusive evidence to confirm these hypotheses. [9] [10] [11] Given an aging population, the effects of an alkaline diet on public health may offer some benefits due to its focus on an increase in fresh fruits and vegetables, but there are limited scientific studies on the topic. [11]

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Vitamin K is a family of structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements. The human body requires vitamin K for post-synthesis modification of certain proteins that are required for blood coagulation or for controlling binding of calcium in bones and other tissues. The complete synthesis involves final modification of these so-called "Gla proteins" by the enzyme gamma-glutamyl carboxylase that uses vitamin K as a cofactor.

<span class="mw-page-title-main">Dietary fiber</span> Portion of plant-derived food that cannot be completely digested

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<span class="mw-page-title-main">Dietary supplement</span> Product providing additional nutrients

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References

  1. 1 2 Fenton, Tanis. "The alkaline diet, the acid-ash hypothesis and bone health". Dairy Nutrition.
  2. 1 2 Cunningham, Eleese (October 2009). "What Impact Does pH Have on Food and Nutrition?". Journal of the American Dietetic Association. 109 (10): 1816. doi:10.1016/j.jada.2009.08.028. PMID   19782182.
  3. 1 2 Fenton, Tanis R; Lyon, Andrew W; Eliasziw, Michael; Tough, Suzanne C; Hanley, David A (December 2009). "Phosphate decreases urine calcium and increases calcium balance: A meta-analysis of the osteoporosis acid-ash diet hypothesis". Nutrition Journal. 8 (1): 41. doi: 10.1186/1475-2891-8-41 . PMC   2761938 . PMID   19754972.
  4. 1 2 Fenton, Tanis R; Tough, Suzanne C; Lyon, Andrew W; Eliasziw, Misha; Hanley, David A (December 2011). "Causal assessment of dietary acid load and bone disease: a systematic review & meta-analysis applying Hill's epidemiologic criteria for causality". Nutrition Journal. 10 (1): 41. doi: 10.1186/1475-2891-10-41 . PMC   3114717 . PMID   21529374.
  5. ↑ Fenton, Tanis R; Lyon, Andrew W; Eliasziw, Michael; Tough, Suzanne C; Hanley, David A (November 2009). "Meta-Analysis of the Effect of the Acid-Ash Hypothesis of Osteoporosis on Calcium Balance". Journal of Bone and Mineral Research. 24 (11): 1835–1840. doi: 10.1359/jbmr.090515 . PMID   19419322. S2CID   28279996.
  6. ↑ Fenton, Tanis R; Lyon, Andrew W (October 2011). "Milk and Acid-Base Balance: Proposed Hypothesis versus Scientific Evidence". Journal of the American College of Nutrition. 30 (sup5): 471S–475S. doi:10.1080/07315724.2011.10719992. PMID   22081694. S2CID   23613566.
  7. ↑ Lambert, H.; Frassetto, L.; Moore, J. B.; Torgerson, D.; Gannon, R.; Burckhardt, P.; Lanham-New, S. (April 2015). "The effect of supplementation with alkaline potassium salts on bone metabolism: a meta-analysis" (PDF). Osteoporosis International. 26 (4): 1311–1318. doi:10.1007/s00198-014-3006-9. PMID   25572045. S2CID   12536343.
  8. ↑ Food and Nutrition Board. Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate (2005), page 189. National Academies Press.
  9. ↑ Pizzorno, Joseph; Frassetto, Lynda A.; Katzinger, Joseph (28 April 2010). "Diet-induced acidosis: is it real and clinically relevant?". British Journal of Nutrition. 103 (8): 1185–1194. doi: 10.1017/S0007114509993047 . PMID   20003625.
  10. ↑ "Alkaline Diets". WebMD. Retrieved 5 February 2014.
  11. 1 2 Schwalfenberg, Gerry K. (2012). "The Alkaline Diet: Is There Evidence That an Alkaline pH Diet Benefits Health?". Journal of Environmental and Public Health. 2012: 727630. doi: 10.1155/2012/727630 . PMC   3195546 . PMID   22013455.
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